{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:52:48Z","timestamp":1791305568573,"version":"4.3.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0084"],"award-info":[{"award-number":["2023YFS0084"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001444"],"award-info":[{"award-number":["82001444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Depression in older people is a major contributor to global disease burden and functional impairment. While trait gratitude, a stable tendency to appreciate others\u2019 help, has been shown to alleviate depressive symptoms across populations, less is known about its neuroanatomical substrates and protective neuropsychological mechanisms against depression symptoms in aging populations. Here, we investigated the structural neural correlates of trait gratitude in 120 community-dwelling older women using voxel-based morphometry analysis of T1-weighted magnetic resonance imaging data. First, the whole-brain correlation analysis identified a negative association between trait gratitude and regional gray matter volume (GMV) in the right precuneus. Mediation analyses further suggested that trait gratitude could mediate the impact of regional GMV in right precuneus on depression symptoms. Critically, supplemental analyses showed that the results persisted even after controlling for anxiety and stress symptoms, as well as general personality traits. Our study presents novel evidence for the neuroanatomical basis of trait gratitude in general older women and highlights a brain\u2013personality\u2013symptom pathway for protecting against depression in which GMV affects depressive symptoms via trait gratitude. These findings deepen understanding of gratitude\u2019s protective role in late-life mental health while highlighting potential neurostructural markers for resilience against depression.<\/jats:p>","DOI":"10.1093\/cercor\/bhag165","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:23:12Z","timestamp":1789672992000},"source":"Crossref","is-referenced-by-count":0,"title":["Gratitude mediates the link of precuneus volume to depression in older women"],"prefix":"10.1093","volume":"36","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Southwest Jiao Tong University, The Third People\u2019s Hospital of Chengdu , 82 Qinglong St, Qingyang District, Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China , 32# W. Sec 2, 1st Ring Rd., Qingyang District, Chengdu 610072 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-0280","authenticated-orcid":false,"given":"Xueling","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University , No. 37 Guo Xue Xiang, Wuhou District, Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Southwest Jiao Tong University, The Third People\u2019s Hospital of Chengdu , 82 Qinglong St, Qingyang District, Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Southwest Jiao Tong University, The Third People\u2019s Hospital of Chengdu , 82 Qinglong St, Qingyang District, Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9830-0527","authenticated-orcid":false,"given":"Dongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , 32# W. Sec 2, 1st Ring Rd., Qingyang District, Chengdu 610072 ,","place":["China"]},{"name":"Department of Nursing, Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China , 4# Sec 2, Jianshe North Rd., Chenghua District, Chengdu 610054 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-1915","authenticated-orcid":false,"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital, Sichuan University , No. 37 Guo Xue Xiang, Wuhou District, Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026100612050476700_ref1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s43587-022-00203-1","article-title":"Trajectories of depressive 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