{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:26:05Z","timestamp":1775798765287,"version":"3.50.1"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1093\/cercor\/bhr328","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T02:03:40Z","timestamp":1322877820000},"page":"2495-2518","source":"Crossref","is-referenced-by-count":86,"title":["TRPV1-Dependent and -Independent Alterations in the Limbic Cortex of Neuropathic Mice: Impact on Glial Caspases and Pain Perception"],"prefix":"10.1093","volume":"22","author":[{"given":"Catia","family":"Giordano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Cristino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Luongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Siniscalco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Petrosino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Marabese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Imperatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enza","family":"Palazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"de Novellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabatino","family":"Maione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"issue":"6","key":"key\n\t\t\t\t20170521000953_bib1","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1523\/JNEUROSCI.06-06-01803.1986","article-title":"Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla","volume":"6","author":"Aimone","year":"1986","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib2","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1523\/JNEUROSCI.6103-09.2010","article-title":"Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models","volume":"30","author":"Alter","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpain.2004.11.001","article-title":"Human brain mechanisms of pain perception and regulation in health and disease","volume":"9","author":"Apkarian","year":"2005","journal-title":"Eur J Pain"},{"key":"key\n\t\t\t\t20170521000953_bib4","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1523\/JNEUROSCI.2541-04.2004","article-title":"Chronic back pain is associated with decreased prefrontal and thalamic gray matter density","volume":"24","author":"Apkarian","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib5","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1523\/JNEUROSCI.4123-07.2008","article-title":"Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics","volume":"28","author":"Baliki","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/bbrc.1998.8874","article-title":"Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase","volume":"248","author":"Bisogno","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170521000953_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bj3220671","article-title":"Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells","volume":"322","author":"Bisogno","year":"1997","journal-title":"Biochem J"},{"issue":"3","key":"key\n\t\t\t\t20170521000953_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pain.2005.06.024","article-title":"Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice","volume":"117","author":"B\u00f6lcskei","year":"2005","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib9","first-page":"141","volume-title":"Advances in pain research and therapy","author":"Bonica","year":"1970"},{"key":"key\n\t\t\t\t20170521000953_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1155\/2007\/741897","article-title":"Fifteen minutes of left prefrontal repetitive transcranial magnetic stimulation acutely increases thermal pain thresholds in healthy adults","volume":"12","author":"Borckardt","year":"2007","journal-title":"Pain Res Manag"},{"key":"key\n\t\t\t\t20170521000953_bib11","doi-asserted-by":"crossref","first-page":"14.e1","DOI":"10.1016\/j.pain.2005.10.036","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170521000953_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/sj.bjp.0706093","article-title":"The expanding field of cannabimimetic and related lipid mediators","volume":"144","author":"Bradshaw","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"12","key":"key\n\t\t\t\t20170521000953_bib14","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0028-3908(00)00079-4","article-title":"Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective","volume":"39","author":"Bruno","year":"2000","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170521000953_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/eujp.1999.0158","article-title":"Descending facilitatory modulation of a behavioural nociceptive response by stimulation in the adult rat anterior cingulate cortex","volume":"4","author":"Calejesan","year":"2000","journal-title":"Eur J Pain"},{"key":"key\n\t\t\t\t20170521000953_bib16","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1096\/fj.09-134346","article-title":"Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors","author":"Camprub\u00ed-Robles","year":"2009","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170521000953_bib17","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1523\/JNEUROSCI.4300-08.2009","article-title":"Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain","volume":"29","author":"Cao","year":"2009","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib18","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1523\/JNEUROSCI.3536-06.2007","article-title":"Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception","volume":"27","author":"Carrasquillo","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pain.2009.06.014","article-title":"Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor","volume":"145","author":"Centeno","year":"2009","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00018-004-4413-4","article-title":"Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons","volume":"62","author":"Chee","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20170521000953_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.mcn.2007.12.006","article-title":"Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice","volume":"37","author":"Christoph","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib22","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1152\/jn.00188.2002","article-title":"Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex","volume":"88","author":"Constantinidis","year":"2002","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170521000953_bib23","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.neuroscience.2006.02.074","article-title":"Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain","volume":"139","author":"Cristino","year":"2006","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170521000953_bib24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuroscience.2007.11.047","article-title":"Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain","volume":"151","author":"Cristino","year":"2008","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170521000953_bib25","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1523\/JNEUROSCI.1246-06.2006","article-title":"TRPV1 receptors in the CNS play a key role on broad-spectrum analgesia of TRPV1 antagonists","volume":"26","author":"Cui","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neuroscience.2008.03.055","article-title":"Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats","volume":"154","author":"Czaja","year":"2008","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170521000953_bib27","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D'Amelio","year":"2010","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170521000953_bib28","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.neuropharm.2008.06.023","article-title":"The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats","volume":"55","author":"de Novellis","year":"2008","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170521000953_bib29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuropharm.2003.10.014","article-title":"Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II","volume":"46","author":"de Novellis","year":"2004","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170521000953_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1744-8069-7-7","article-title":"The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats","volume":"7","author":"de Novellis","year":"2011","journal-title":"Mol Pain"},{"key":"key\n\t\t\t\t20170521000953_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0014-5793(00)02082-2","article-title":"Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity","volume":"483","author":"De Petrocellis","year":"2000","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170521000953_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/eujp.1998.0102","article-title":"Cerebral responses to pain in patients suffering acute post-dental extraction pain measured by positron emission tomography (PET)","volume":"3","author":"Derbyshire","year":"1999","journal-title":"Eur J Pain"},{"key":"key\n\t\t\t\t20170521000953_bib33","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20170521000953_bib34","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1\u03b2 as the gatekeeper of inflammation","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170521000953_bib35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0959-4388(02)00340-9","article-title":"Endovanilloid signaling in pain","volume":"12","author":"Di Marzo","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"key\n\t\t\t\t20170521000953_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/cercor\/bhj143","article-title":"Amygdala-prefrontal cortical circuitry regulates effort-based decision making","volume":"17","author":"Floresco","year":"2007","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170521000953_bib37","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1523\/JNEUROSCI.5474-06.2007","article-title":"Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway","volume":"27","author":"Floresco","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib38","volume-title":"The mouse brain in the stereotaxic coordinates","author":"Franklin","year":"1997"},{"issue":"1\u20133","key":"key\n\t\t\t\t20170521000953_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejphar.2008.11.060","article-title":"A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice","volume":"603","author":"Fuccio","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib40","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuroscience.2006.01.026","article-title":"Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex","volume":"139","author":"Gabbott","year":"2006","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170521000953_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1097-4644(19990401)73:1<97::AID-JCB11>3.0.CO;2-M","article-title":"Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product","volume":"73","author":"Galderisi","year":"1999","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170521000953_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.pain.2007.10.003","article-title":"Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder","volume":"137","author":"G\u00fcndel","year":"2008","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00002508-199806000-00003","article-title":"Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction","volume":"14","author":"Hautkappe","year":"1998","journal-title":"Clin J Pain"},{"key":"key\n\t\t\t\t20170521000953_bib44","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1471-4159.2008.05220.x","article-title":"The TRPV1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy","volume":"105","author":"Hong","year":"2008","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170521000953_bib45","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1471-4159.1985.tb08753.x","article-title":"Monitoring the effect of a tryptophan load on brain indole metabolism in freely moving rats by simultaneous cerebrospinal fluid sampling and brain dialysis","volume":"44","author":"Hutson","year":"1985","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170521000953_bib46","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1523\/JNEUROSCI.23-31-09987.2003","article-title":"Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat","volume":"23","author":"Ishikawa","year":"2003","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib47","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01808","article-title":"Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex","volume":"424","author":"Jasmin","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170521000953_bib48","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1523\/JNEUROSCI.0225-10.2010","article-title":"Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation","volume":"30","author":"Ji","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib49","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1111\/j.1460-9568.2004.03750.x","article-title":"Caspase signalling in neuropathic and inflammatory pain in the rat","volume":"20","author":"Joseph","year":"2004","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib50","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jpain.2008.12.003","article-title":"Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat","volume":"10","author":"Joseph","year":"2009","journal-title":"J Pain"},{"key":"key\n\t\t\t\t20170521000953_bib51","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/cercor\/8.5.437","article-title":"Firing characteristics of deep layer neurons in prefrontal cortex in rats performing spatial working memory tasks","volume":"8","author":"Jung","year":"1998","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20170521000953_bib52","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1523\/JNEUROSCI.4166-04.2005","article-title":"Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro","volume":"25","author":"Kim","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1744-8069-6-62","article-title":"In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice","volume":"6","author":"Koga","year":"2010","journal-title":"Mol Pain"},{"key":"key\n\t\t\t\t20170521000953_bib54","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/art.22460","article-title":"Arthritic pain is processed in brain areas concerned with emotions and fear","volume":"56","author":"Kulkarni","year":"2007","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20170521000953_bib55","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1523\/JNEUROSCI.0707-06.2006","article-title":"Cannabinoids potentiate emotional learning plasticity in neurons of the medial prefrontal cortex through basolateral amygdala inputs","volume":"26","author":"Laviolette","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib56","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.pain.2004.01.022","article-title":"Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia","volume":"109","author":"Lichtman","year":"2004","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib57","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1523\/JNEUROSCI.0945-05.2005","article-title":"Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C\u03b24 signaling cascade in the cerebellum","volume":"25","author":"Maejima","year":"2005","journal-title":"J Neurosci"},{"issue":"3","key":"key\n\t\t\t\t20170521000953_bib58","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1124\/jpet.105.093286","article-title":"Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors","volume":"316","author":"Maione","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170521000953_bib59","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/sj.bjp.0707145","article-title":"Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors","volume":"150","author":"Maione","year":"2007","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-3959(99)00269-9","article-title":"Periaqueductal gray matter metabotropic glutamate receptors modulate formalin-induced nociception","volume":"85","author":"Maione","year":"2000","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib61","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00001756-200201210-00024","article-title":"Apoptotic genes expression in the lumbar dorsal horn in a model neuropathic pain in rat","volume":"13","author":"Maione","year":"2002","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170521000953_bib62","doi-asserted-by":"crossref","DOI":"10.1007\/3-7643-7379-2","volume-title":"Turning up the heat on pain: TRPV1 receptors in pain and inflammation","author":"Malmberg","year":"2005"},{"key":"key\n\t\t\t\t20170521000953_bib63","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nn1458","article-title":"Endocannabinoid signaling depends on the spatial pattern of synapse activation","volume":"8","author":"Marcaggi","year":"2005","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib64","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170521000953_bib65","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11055-009-9143-5","article-title":"Studies of learning and memory processes in adult rats in conditions of intracerebral administration of caspase inhibitors","volume":"39","author":"Merkina","year":"2009","journal-title":"Neurosci Behav Physiol"},{"key":"key\n\t\t\t\t20170521000953_bib66","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1073\/pnas.0809897106","article-title":"Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain","volume":"106","author":"Metz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170521000953_bib67","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170521000953_bib68","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pain.2007.03.003","article-title":"D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry","volume":"132","author":"Millecamps","year":"2007","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib69","doi-asserted-by":"crossref","first-page":"38496","DOI":"10.1074\/jbc.M507429200","article-title":"Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists","volume":"280","author":"Movahed","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170521000953_bib70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mcn.2008.09.001","article-title":"TRPV1 channels facilitate glutamate transmission in the striatum","volume":"40","author":"Musella","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib71","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.nbd.2011.05.018","article-title":"Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-\u03b1 and of IL-1\u03b2 in experimental autoimmune encephalomyelitis","volume":"43","author":"Musumeci","year":"2011","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20170521000953_bib72","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.eurpsy.2007.02.006","article-title":"Insular cortex and neuropsychiatric disorders: a review of recent literature","volume":"22","author":"Nagai","year":"2007","journal-title":"Eur Psychiatry"},{"key":"key\n\t\t\t\t20170521000953_bib73","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.brainresrev.2008.12.014","article-title":"Forebrain pain mechanisms","volume":"60","author":"Neugebauer","year":"2009","journal-title":"Brain Res Rev"},{"key":"key\n\t\t\t\t20170521000953_bib74","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1523\/JNEUROSCI.23-01-00052.2003","article-title":"Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5","volume":"23","author":"Neugebauer","year":"2003","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1073858403261077","article-title":"The amygdala and persistent pain","volume":"10","author":"Neugebauer","year":"2004","journal-title":"Neuroscientist"},{"key":"key\n\t\t\t\t20170521000953_bib76","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pain.2005.10.014","article-title":"Neural correlates of individual differences in pain-related fear and anxiety","volume":"20","author":"Ochsner","year":"2006","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170521000953_bib77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00018-004-4283-9","article-title":"Cortical modulation of pain","volume":"62","author":"Ohara","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20170521000953_bib78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2005.11.025","article-title":"Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia","volume":"530","author":"Oliva","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib79","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0014-2999(02)01367-5","article-title":"Interaction between vanilloid and glutamate receptors in the central modulation of nociception","volume":"439","author":"Palazzo","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib80","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.mce.2008.01.013","article-title":"Role of TRPV1 receptors in descending modulation of pain","volume":"286","author":"Palazzo","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170521000953_bib81","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuron.2010.02.017","article-title":"Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons","volume":"65","author":"Peters","year":"2010","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170521000953_bib82","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1152\/jn.1998.80.6.3312","article-title":"Temporal and intensity coding of pain in human cortex","volume":"80","author":"Porro","year":"1998","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170521000953_bib83","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.bbadis.2007.05.006","article-title":"TRP channels in cancer","volume":"1772","author":"Prevarskaya","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170521000953_bib84","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1523\/JNEUROSCI.4773-03.2004","article-title":"Direct interaction of adenosine with the TRPV1 channel protein","volume":"24","author":"Puntambekar","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib85","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1523\/JNEUROSCI.5284-05.2006","article-title":"Dendritic calcium spikes are tunable triggers of cannabinoid release and short-term synaptic plasticity in cerebellar Purkinje neurons","volume":"26","author":"Rancz","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib86","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.103.050948","article-title":"Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice","volume":"306","author":"Rashid","year":"2003","journal-title":"J Pharmacol Exp Ther (b)"},{"key":"key\n\t\t\t\t20170521000953_bib87","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1124\/jpet.102.046250","article-title":"Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin creams in neuropathic pain","volume":"304","author":"Rashid","year":"2003","journal-title":"J Pharmacol Exp Ther (a)"},{"key":"key\n\t\t\t\t20170521000953_bib88","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.bjp.0707440","article-title":"Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate","volume":"152","author":"Rea","year":"2007","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib89","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2003.10.001","article-title":"[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution","volume":"995","author":"Roberts","year":"2004","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170521000953_bib90","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury","volume":"25","author":"Scholz","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib91","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1044-7431(03)00121-0","article-title":"Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons","volume":"24","author":"Shin","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib92","first-page":"635","article-title":"Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain","volume":"60","author":"Simone","year":"2008","journal-title":"Sheng Li Xue Bao"},{"key":"key\n\t\t\t\t20170521000953_bib93","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2006.11.024","article-title":"Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning","volume":"53","author":"Sindreu","year":"2007","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170521000953_bib94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1389450053344966","article-title":"Neuropathic pain: is the end of suffering starting in the gene therapy?","volume":"6","author":"Siniscalco","year":"2005","journal-title":"Curr Drug Targets"},{"key":"key\n\t\t\t\t20170521000953_bib95","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.phrs.2006.11.009","article-title":"Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain","volume":"55","author":"Siniscalco","year":"2007","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20170521000953_bib96","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.phrs.2008.01.007","article-title":"Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats","volume":"57","author":"Siniscalco","year":"2008","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20170521000953_bib97","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/138161208783330790","article-title":"TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications","volume":"14","author":"Starowicz","year":"2008","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20170521000953_bib98","doi-asserted-by":"crossref","first-page":"13739","DOI":"10.1523\/JNEUROSCI.3258-07.2007","article-title":"Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways","volume":"27","author":"Starowicz","year":"2007","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib99","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1744-8069-2-34","article-title":"Hot receptors in the brain","volume":"2","author":"Steenland","year":"2006","journal-title":"Mol Pain"},{"key":"key\n\t\t\t\t20170521000953_bib100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2006.119362","article-title":"Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol","volume":"577","author":"Szabo","year":"2006","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170521000953_bib101","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1309\/7AYY-VVH1-GQT5-J4R2","article-title":"Vanilloid (capsaicin) receptors in health and disease","volume":"118","author":"Szallasi","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"key\n\t\t\t\t20170521000953_bib102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20170521000953_bib103","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170521000953_bib104","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1460-9568.2004.03501.x","article-title":"Influence of the hippocampus on interneurons of the rat prefrontal cortex. 1","volume":"20","author":"Tierney","year":"2004","journal-title":"Eur J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib105","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2007.07.012","article-title":"The cerebral signature for pain perception and its modulation","volume":"55","author":"Tracey","year":"2007","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170521000953_bib106","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.plipres.2010.02.003","article-title":"N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)","volume":"49","author":"Ueda","year":"2010","journal-title":"Prog Lipid Res"},{"key":"key\n\t\t\t\t20170521000953_bib107","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00429-010-0247-z","article-title":"Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse","volume":"214","author":"Van De Werd","year":"2010","journal-title":"Brain Struct Funct"},{"key":"key\n\t\t\t\t20170521000953_bib108","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib109","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuroscience.2004.09.041","article-title":"Ca3 neuronal activities of dorsal and ventral hippocampus are differentially altered in rats after prolonged post-ischemic survival","volume":"130","author":"Wu","year":"2005","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170521000953_bib110","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1523\/JNEUROSCI.1812-08.2008","article-title":"Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex","volume":"28","author":"Xu","year":"2008","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib111","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(01)01303-6","article-title":"Pathobiology of neuropathic pain","volume":"429","author":"Zimmermann","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170521000953_bib112","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tins.2008.01.003","article-title":"Cortical excitation and chronic pain","volume":"31","author":"Zhuo","year":"2008","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20170521000953_bib113","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/22\/11\/2495\/17305340\/bhr328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T19:33:55Z","timestamp":1741980835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article-lookup\/doi\/10.1093\/cercor\/bhr328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":113,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2012,11]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhr328","relation":{},"ISSN":["1460-2199","1047-3211"],"issn-type":[{"value":"1460-2199","type":"electronic"},{"value":"1047-3211","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}