{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:27:48Z","timestamp":1779355668175,"version":"3.51.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005240","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFA0501000"],"award-info":[{"award-number":["2016YFA0501000"]}],"id":[{"id":"10.13039\/501100005240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005240","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0104200"],"award-info":[{"award-number":["2017YFA0104200"]}],"id":[{"id":"10.13039\/501100005240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31 300 905"],"award-info":[{"award-number":["31 300 905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31190060"],"award-info":[{"award-number":["31190060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471308"],"award-info":[{"award-number":["31471308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671057"],"award-info":[{"award-number":["31671057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public support project of Science and Technology Department of Zhejiang Province","award":["2013 C37001"],"award-info":[{"award-number":["2013 C37001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"DOI":"10.1093\/cercor\/bhx212","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T15:13:03Z","timestamp":1500909183000},"page":"3457-3467","source":"Crossref","is-referenced-by-count":14,"title":["Alternative Splicing of Disabled-1 Controls Multipolar-to-Bipolar Transition of Migrating Neurons in the Neocortex"],"prefix":"10.1093","volume":"28","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseline","family":"Godbout","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8603-0777","authenticated-orcid":false,"given":"Zhihua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,8,22]]},"reference":[{"key":"key\n\t\t\t\t20180911110410_bhx212C1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cub.2004.03.038","article-title":"Activation of a Dab1\/CrkL\/C3G\/Rap1 pathway in Reelin-stimulated neurons","volume":"14","author":"Ballif","year":"2004","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C2","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1074\/jbc.M207178200","article-title":"The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse","volume":"278","author":"Bar","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180911110410_bhx212C3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2005.08.026","article-title":"A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to \u03b1- and \u03b2-neurexins","volume":"48","author":"Boucard","year":"2005","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrn2252","article-title":"Development of the human cerebral cortex: Boulder Committee revisited","volume":"9","author":"Bystron","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C5","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1242\/jcs.01320","article-title":"Interaction between Dab1 and CrkII is promoted by Reelin signaling","volume":"117","author":"Chen","year":"2004","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2008.02.016","article-title":"Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion","volume":"58","author":"Chen","year":"2008","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.neuron.2007.05.029","article-title":"Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2","volume":"54","author":"Chubykin","year":"2007","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tins.2007.12.003","article-title":"A mechanism for inside-out lamination in the neocortex","volume":"31","author":"Cooper","year":"2008","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1083\/jcb.201305021","article-title":"Cell biology in neuroscience: mechanisms of cell migration in the nervous system","volume":"202","author":"Cooper","year":"2013","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fncel.2014.00386","article-title":"Molecules and mechanisms that regulate multipolar migration in the intermediate zone","volume":"8","author":"Cooper","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C11","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1101\/gad.1604207","article-title":"Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development","volume":"21","author":"Feng","year":"2007","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180911110410_bhx212C12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/MCB.00663-08","article-title":"Dual functions of Dab1 during brain development","volume":"29","author":"Feng","year":"2009","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2011.01.003","article-title":"Reelin regulates cadherin function via Dab1\/Rap1 to control neuronal migration and lamination in the neocortex","volume":"69","author":"Franco","year":"2011","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C14","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1128\/MCB.00570-12","article-title":"Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions","volume":"32","author":"Gao","year":"2012","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2013.10.045","article-title":"Cortical evolution: judge the brain by its cover","volume":"80","author":"Geschwind","year":"2013","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0168-9525(00)02176-4","article-title":"Alternative splicing increasing diversity in the proteomic world","volume":"17","author":"Graveley","year":"2001","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20180911110410_bhx212C17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20256","article-title":"Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone","volume":"479","author":"Hatanaka","year":"2004","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0896-6273(00)80861-2","article-title":"Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation","volume":"24","author":"Hiesberger","year":"1999","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/cne.23691","article-title":"Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex","volume":"523","author":"Hirota","year":"2015","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/emboj\/16.1.121","article-title":"Mouse disabled (mDab1) a Src binding protein implicated in neuronal development","volume":"16","author":"Howell","year":"1997","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180911110410_bhx212C21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1101\/gad.13.6.643","article-title":"Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning","volume":"13","author":"Howell","year":"1999","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180911110410_bhx212C22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbrc.2004.04.023","article-title":"Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins","volume":"318","author":"Huang","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20180911110410_bhx212C23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nn.2816","article-title":"Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex","volume":"14","author":"Jossin","year":"2011","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jmb.2007.01.068","article-title":"Hierarchical disabled-1 tyrosine phosphorylation in Src family kinase activation and neurite formation","volume":"368","author":"Katyal","year":"2007","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C25","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/sj.emboj.7600185","article-title":"Alternative splicing modulates Disabled-1 (Dab1) function in the developing chick retina","volume":"23","author":"Katyal","year":"2004","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180911110410_bhx212C26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neuron.2009.12.012","article-title":"LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation","volume":"64","author":"Ko","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C27","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/nn.3870","article-title":"FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry","volume":"17","author":"La Fata","year":"2014","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C28","doi-asserted-by":"crossref","first-page":"8280","DOI":"10.1073\/pnas.1205880109","article-title":"Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex","volume":"109","author":"Liu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180911110410_bhx212C29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn1172","article-title":"Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases","volume":"7","author":"Noctor","year":"2004","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C30","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1242\/dev.02854","article-title":"Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex","volume":"134","author":"Ohshima","year":"2007","journal-title":"Development"},{"key":"key\n\t\t\t\t20180911110410_bhx212C31","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1523\/JNEUROSCI.3000-05.2006","article-title":"Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression","volume":"26","author":"Olson","year":"2006","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0166-2236(00)01553-8","article-title":"The origin and migration of cortical neurones new vistas","volume":"23","author":"Parnavelas","year":"2000","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C33","doi-asserted-by":"crossref","first-page":"52848","DOI":"10.1074\/jbc.M309436200","article-title":"Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase","volume":"278","author":"Piechotta","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180911110410_bhx212C34","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.1128\/MCB.23.20.7210-7221.2003","article-title":"Nck\u03b2 interacts with tyrosine-phosphorylated Disabled 1 and redistributes in Reelin-stimulated neurons","volume":"23","author":"Pramatarova","year":"2003","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C35","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1146\/annurev.neuro.24.1.1005","article-title":"Role of the Reelin signaling pathway in central nervous system development","volume":"24","author":"Rice","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/dbio.2001.0439","article-title":"Efficient gene transfer into the embryonic mouse brain using in vivo electroporation","volume":"240","author":"Saito","year":"2001","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20180911110410_bhx212C37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(04)00222-3","article-title":"Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis","volume":"42","author":"Sanada","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180911110410_bhx212C38","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhv341","article-title":"Rap1 GTPases are master regulators of neural cell polarity in the developing neocortex","author":"Shah","year":"2016","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20180911110410_bhx212C39","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1523\/JNEUROSCI.0035-10.2010","article-title":"Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration","volume":"30","author":"Simo","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C40","first-page":"767","article-title":"Identification of phosphotyrosine peptide motifs which bind to SH2 domains","volume":"72","author":"Songyang","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180911110410_bhx212C41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0306-4522(01)00016-1","article-title":"Efficient in utero gene transfer system to the developing mouse brain using electroporation visualization of neuronal migration in the developing cortex","volume":"103","author":"Tabata","year":"2001","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180911110410_bhx212C42","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1158\/0008-5472.CAN-08-1769","article-title":"Identification of alternative splicing markers for breast cancer","volume":"68","author":"Venables","year":"2008","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180911110410_bhx212C43","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhw060","article-title":"Behavioral resilience and sensitivity to locally restricted cortical migration deficits induced by in utero knockdown of Disabled-1 in the adult rat","author":"Vomund","year":"2016","journal-title":"Cereb Cortex"},{"key":"key\n\t\t\t\t20180911110410_bhx212C44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tibs.2012.05.001","article-title":"Linear motifs: lost in (pre)translation","volume":"37","author":"Weatheritt","year":"2012","journal-title":"Trends Biochem Sci"},{"key":"key\n\t\t\t\t20180911110410_bhx212C45","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.neuron.2010.05.007","article-title":"Nova2 regulates neuronal migration through an RNA switch in Disabled-1 signaling","volume":"66","author":"Yano","year":"2010","journal-title":"Neuron"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/28\/10\/3457\/25714272\/bhx212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T10:36:27Z","timestamp":1569926187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/28\/10\/3457\/4091095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,22]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,8,22]]},"published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhx212","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10]]},"published":{"date-parts":[[2017,8,22]]}}}