{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:27:27Z","timestamp":1762298847340,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"JST\/RISTEX"},{"name":"JST\/CREST"},{"name":"Grant-in-Aid for Young Scientists","award":["KAKENHI 23700306"],"award-info":[{"award-number":["KAKENHI 23700306"]}]},{"name":"Grant-in-Aid for Young Scientists","award":["KAKENHI 25700012"],"award-info":[{"award-number":["KAKENHI 25700012"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.<\/jats:p>","DOI":"10.1093\/cercor\/bhy189","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T15:13:27Z","timestamp":1532704407000},"page":"3211-3219","source":"Crossref","is-referenced-by-count":10,"title":["A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity"],"prefix":"10.1093","volume":"29","author":[{"given":"Hikaru","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Taki","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"},{"name":"Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan"},{"name":"Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Nouchi","sequence":"additional","affiliation":[{"name":"Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan"},{"name":"Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan"},{"name":"Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"School of Medicine, Kobe University, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kotozaki","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishu","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"},{"name":"Division of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan"},{"name":"Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugiko","family":"Hanawa","sequence":"additional","affiliation":[{"name":"Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Araki","sequence":"additional","affiliation":[{"name":"Advantage Risk Management Co., Ltd, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Makoto","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Language Sciences, Graduate School of Humanities, Tokyo Metropolitan University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Sakaki","sequence":"additional","affiliation":[{"name":"Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Collaborative Research Center for Happiness Co-Creation Society through Intelligent Communications, Tokyo Institute of Technology, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Yokota","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Magistro","sequence":"additional","affiliation":[{"name":"Department of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Sassa","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"},{"name":"Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"},{"name":"Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"2019072210300009300_bhy189C1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3102\/10769986025001060","article-title":"On the adaptive control of the false discovery rate in multiple testing with independent statistics","volume":"25","author":"Benjamini","year":"2000","journal-title":"J Educ Behav Stat"},{"key":"2019072210300009300_bhy189C2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/archgenpsychiatry.2010.96","article-title":"Genetic variation in CACNA1C affects brain circuitries related to mental illness","volume":"67","author":"Bigos","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"2019072210300009300_bhy189C3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2010.06.019","article-title":"Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans","volume":"68","author":"Dao","year":"2010","journal-title":"Biol Psychiatry"},{"key":"2019072210300009300_bhy189C4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.neuroimage.2005.04.039","article-title":"Detecting and adjusting for artifacts in fMRI time series data","volume":"27","author":"Diedrichsen","year":"2005","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C5","doi-asserted-by":"crossref","first-page":"e0157086","DOI":"10.1371\/journal.pone.0157086","article-title":"Functional characterization of schizophrenia-associated variation in CACNA1C","volume":"11","author":"Eckart","year":"2016","journal-title":"PLoS One"},{"key":"2019072210300009300_bhy189C6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroimage.2014.03.007","article-title":"Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects","volume":"94","author":"Erk","year":"2014","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.biopsych.2013.11.025","article-title":"Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C","volume":"76","author":"Erk","year":"2014","journal-title":"Biol Psychiatry"},{"key":"2019072210300009300_bhy189C8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1001\/archgenpsychiatry.2010.94","article-title":"Brain function in carriers of a genome-wide supported bipolar disorder variant","volume":"67","author":"Erk","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"2019072210300009300_bhy189C9","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"Genovese","year":"2002","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.biopsych.2010.04.033","article-title":"Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray\u2019s trait \u201csensitivity to punishment\u201d","volume":"68","author":"Hahn","year":"2010","journal-title":"Biol Psychiatry"},{"key":"2019072210300009300_bhy189C11","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.neuron.2014.01.010","article-title":"Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity","volume":"81","author":"Heck","year":"2014","journal-title":"Neuron"},{"key":"2019072210300009300_bhy189C12","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.euroneuro.2015.09.012","article-title":"A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder","volume":"25","author":"Heilbronner","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"2019072210300009300_bhy189C13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00406-013-0428-x","article-title":"A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval","volume":"264","author":"Krug","year":"2014","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2019072210300009300_bhy189C14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"2019072210300009300_bhy189C15","doi-asserted-by":"crossref","first-page":"e18954","DOI":"10.1371\/journal.pone.0018954","article-title":"Impact of visual repetition rate on intrinsic properties of low frequency fluctuations in the visual network","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"2019072210300009300_bhy189C16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12035-009-8079-7","article-title":"Chronic stress-and sex-specific neuromorphological and functional changes in limbic structures","volume":"40","author":"McLaughlin","year":"2009","journal-title":"Mol Neurobiol"},{"key":"2019072210300009300_bhy189C17","doi-asserted-by":"crossref","first-page":"9883","DOI":"10.1523\/JNEUROSCI.1531-05.2005","article-title":"Role of hippocampal Cav1. 2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory","volume":"25","author":"Moosmang","year":"2005","journal-title":"J Neurosci"},{"key":"2019072210300009300_bhy189C18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ajmg.b.32106","article-title":"Replication of genome\u2010wide association studies (GWAS) loci for sleep in the British G1219 cohort","volume":"162","author":"Parsons","year":"2013","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"2019072210300009300_bhy189C19","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1399-5618.2010.00817.x","article-title":"Evidence for cis\u2010acting regulation of ANK3 and CACNA1C gene expression","volume":"12","author":"Quinn","year":"2010","journal-title":"Bipolar Disord"},{"key":"2019072210300009300_bhy189C21","first-page":"1308","article-title":"Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia","volume":"170","author":"Ren","year":"2013","journal-title":"AJ Psychiatry"},{"key":"2019072210300009300_bhy189C22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1399-5618.2011.00924.x","article-title":"The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males","volume":"13","author":"Roussos","year":"2011","journal-title":"Bipolar Disord"},{"key":"2019072210300009300_bhy189C23","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1073\/pnas.0802379105","article-title":"Estrogens directly potentiate neuronal L-type Ca2+ channels","volume":"105","author":"Sarkar","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"2019072210300009300_bhy189C24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s001090000077","article-title":"Molecular mechanisms of calcium-dependent excitotoxicity","volume":"78","author":"Sattler","year":"2000","journal-title":"J Mol Med"},{"key":"2019072210300009300_bhy189C25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00439-010-0862-z","article-title":"An approach based on a genome-wide association study reveals candidate loci for narcolepsy","volume":"128","author":"Shimada","year":"2010","journal-title":"Hum Genet"},{"key":"2019072210300009300_bhy189C26","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuroimage.2010.08.049","article-title":"False positives in neuroimaging genetics using voxel-based morphometry data","volume":"54","author":"Silver","year":"2012","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C28","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","author":"Smoller","year":"2013","journal-title":"Lancet"},{"key":"2019072210300009300_bhy189C29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1042\/BST0340903","article-title":"Role of voltage-gated L-type Ca2+ channel isoforms for brain function","volume":"34","author":"Striessnig","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"2019072210300009300_bhy189C30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/mp.2012.53","article-title":"The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population","volume":"18","author":"Strohmaier","year":"2013","journal-title":"Mol Psychiatry"},{"key":"2019072210300009300_bhy189C31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuroimage.2013.06.044","article-title":"Resting state functional connectivity associated with trait emotional intelligence","volume":"83","author":"Takeuchi","year":"2013","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neuroimage.2017.02.079","article-title":"Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner","volume":"152","author":"Takeuchi","year":"2017","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuroimage.2015.01.053","article-title":"Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele","volume":"110","author":"Takeuchi","year":"2015","journal-title":"Neuroimage"},{"key":"2019072210300009300_bhy189C34","doi-asserted-by":"crossref","first-page":"13642","DOI":"10.1073\/pnas.1303346110","article-title":"Energetic cost of brain functional connectivity","volume":"110","author":"Tomasi","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019072210300009300_bhy189C35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/YPG.0000000000000060","article-title":"Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder","volume":"24","author":"Witt","year":"2014","journal-title":"Psychiatr Genet"},{"key":"2019072210300009300_bhy189C36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"2019072210300009300_bhy189C37","first-page":"13","article-title":"DPARSF: a MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Yan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"2019072210300009300_bhy189C38","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/mp.2014.143","article-title":"Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons","volume":"20","author":"Yoshimizu","year":"2015","journal-title":"Mol Psychiatry"},{"key":"2019072210300009300_bhy189C39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/npp.2011.242","article-title":"The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder","volume":"37","author":"Zhang","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"2019072210300009300_bhy189C40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.schres.2013.12.003","article-title":"Further evidence for genetic association of CACNA1C and schizophrenia: new risk loci in a Han Chinese population and a meta-analysis","volume":"152","author":"Zheng","year":"2014","journal-title":"Schizophr Res"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/29\/8\/3211\/28970384\/bhy189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T10:30:28Z","timestamp":1563791428000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/29\/8\/3211\/5074509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,15]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,15]]},"published-print":{"date-parts":[[2019,7,22]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhy189","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"type":"print","value":"1047-3211"},{"type":"electronic","value":"1460-2199"}],"subject":[],"published-other":{"date-parts":[[2019,8]]},"published":{"date-parts":[[2018,8,15]]}}}