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Despite the absence of cortical malformations, they have intellectual and social disabilities. To search for potential etiologies for these deficits, we compared their brain's structural and white matter organization to 22 controls using structural and diffusion magnetic resonance imaging. Diffusion images were processed to calculate fractional anisotropy (FA) and perform tract reconstructions. Cortical parcellation-based network analysis and gyral topology-based FA analyses were performed. Major interhemispheric, projection and intrahemispheric tracts were manually segmented. Subjects had decreased corpus callosum volume and decreased network efficiency. While only pediatric subjects had diffuse decreases in FA predominantly affecting mid- and long-range tracts, only adult subjects had white matter volume loss associated with decreased cortical surface area. All subjects showed aberrant corticospinal tract trajectory and bilateral absence of the dorsal language network long segment. Furthermore, pediatric subjects had more tracts with decreased FA compared with controls than did adult subjects. These findings define a TUBB3 E410K neuroimaging endophenotype and lead to the hypothesis that the age-related changes are due to microscopic intrahemispheric misguided axons that are pruned during maturation.<\/jats:p>","DOI":"10.1093\/cercor\/bhy231","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T20:34:42Z","timestamp":1535574882000},"page":"3561-3576","source":"Crossref","is-referenced-by-count":17,"title":["Altered White Matter Organization in the TUBB3 E410K Syndrome"],"prefix":"10.1093","volume":"29","author":[{"given":"P Ellen","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Radiology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiho","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Ahtam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia T","family":"Laurentys","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai-Man","family":"Chan","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Brainard","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheena","family":"Chew","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Boston Children\u2019s Hospital, Boston, MA, USA"},{"name":"F.M. 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