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Food-restriction (FR) stress evokes foraging, which translates to increased wheel running exercise (EX) for caged rodents, a maladaptive behavior, since it does not improve food access and exacerbates weight loss. While almost all adolescent rodents increase EX following FR, some then become resilient by suppressing EX by the second\u2013fourth FR day, which minimizes weight loss. We asked whether GABAergic plasticity in the hippocampus may underlie this gain in resilience. In vitro slice physiology revealed doubling of pyramidal neurons\u2019 GABA response in the dorsal hippocampus of food-restricted animals with wheel access (FR + EX for 4 days), but without increase of mIPSC amplitudes. mIPSC frequency increased by 46%, but electron microscopy revealed no increase in axosomatic GABAergic synapse number onto pyramidal cells and only a modest increase (26%) of GABAergic synapse lengths. These changes suggest increase of vesicular release probability and extrasynaptic GABAA receptors and unsilencing of GABAergic synapses. GABAergic synapse lengths correlated with individual\u2019s suppression of wheel running and weight loss. These analyses indicate that EX can have dual roles\u2014exacerbate weight loss but also promote resilience to some by dampening hippocampal excitability.<\/jats:p>","DOI":"10.1093\/cercor\/bhy283","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T23:15:41Z","timestamp":1539818141000},"page":"4035-4049","source":"Crossref","is-referenced-by-count":15,"title":["Voluntary Wheel Running Exercise Evoked by Food-Restriction Stress Exacerbates Weight Loss of Adolescent Female Rats But Also Promotes Resilience by Enhancing GABAergic Inhibition of Pyramidal Neurons in the Dorsal Hippocampus"],"prefix":"10.1093","volume":"29","author":[{"given":"Tara G","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri S","family":"Wable","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tateyama","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex D","family":"Reyes","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-9425","authenticated-orcid":false,"given":"Chiye","family":"Aoki","sequence":"additional","affiliation":[{"name":"Center for Neural Science, NYU, New York, NY, USA"},{"name":"The Neuroscience Institute, NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"2019122608073615000_bhy283C1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/jnr.24035","article-title":"\u03b14\u03b2\u03b4-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane following voluntary exercise and contribute to protection of animals from activity-based anorexia through its location at excitatory synapses","volume":"96","author":"Aoki","year":"2017","journal-title":"J Neurosci Res"},{"key":"2019122608073615000_bhy283C2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2016.01.019","article-title":"Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa","volume":"1654","author":"Aoki","year":"2017","journal-title":"Brain Res"},{"key":"2019122608073615000_bhy283C3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/syn.21528","article-title":"Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor alpha4 and delta subunits at the plasma membrane of hippocampal CA1 spines","volume":"66","author":"Aoki","year":"2012","journal-title":"Synapse"},{"key":"2019122608073615000_bhy283C4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S1054-3589(08)60862-5","article-title":"Noradrenergic modulation of the prefrontal cortex as revealed by electron microscopic immunocytochemistry","volume":"42","author":"Aoki","year":"1998","journal-title":"Adv Pharmacol"},{"key":"2019122608073615000_bhy283C5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroscience.2014.01.011","article-title":"alpha4betadelta-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia","volume":"265","author":"Aoki","year":"2014","journal-title":"Neuroscience"},{"key":"2019122608073615000_bhy283C6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders. 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