{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:31:09Z","timestamp":1780507869809,"version":"3.54.1"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T00:00:00Z","timestamp":1545436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2017-85310-R"],"award-info":[{"award-number":["SAF2017-85310-R"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["PSI2017-85311-P"],"award-info":[{"award-number":["PSI2017-85311-P"]}]},{"name":"Regional Ministry of Innovation, Science and Enterprise, Junta de Andalucia","award":["P12-CTS-2327"],"award-info":[{"award-number":["P12-CTS-2327"]}]},{"name":"International Center on Aging CENIE-POCTEP","award":["0348_CIE_6_E"],"award-info":[{"award-number":["0348_CIE_6_E"]}]},{"name":"CIBERNED","award":["CB06\/05\/1111"],"award-info":[{"award-number":["CB06\/05\/1111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence has shown that microRNAs (miRNAs) are involved in molecular pathways responsible for aging and prevalent aging-related chronic diseases. However, the lack of research linking circulating levels of miRNAs to changes in the aging brain hampers clinical translation. Here, we have investigated if serum expression of brain-enriched miRNAs that have been proposed as potential biomarkers in Alzheimer\u2019s disease (AD) (miR-9, miR-29b, miR-34a, miR-125b, and miR-146a) are also associated with cognitive functioning and changes of the cerebral cortex in normal elderly subjects. Results revealed that candidate miRNAs were linked to changes in cortical thickness (miR-9, miR-29b, miR-34a, and miR-125b), cortical glucose metabolism (miR-29b, miR-125b, and miR-146a), and cognitive performance (miR-9, miR-34a, and miR-125b). While both miR-29b and miR-125b were related to aging-related structural and metabolic cortical changes, only expression levels of miR-125b were associated with patterns of glucose consumption shown by cortical regions that correlated with executive function. Together, these findings suggest that serum expression of AD-related miRNAs are biologically meaningful in aging and may play a role as biomarkers of cerebral vulnerability in late life.<\/jats:p>","DOI":"10.1093\/cercor\/bhy323","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:07:31Z","timestamp":1543234051000},"page":"4426-4437","source":"Crossref","is-referenced-by-count":35,"title":["Aging-Related Changes in Cognition and Cortical Integrity are Associated With Serum Expression of Candidate MicroRNAs for Alzheimer Disease"],"prefix":"10.1093","volume":"29","author":[{"given":"Ines","family":"Maldonado-Lasuncion","sequence":"first","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Atienza","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayely P","family":"Sanchez-Espinosa","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Cantero","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Neuroscience, Pablo de Olavide University, Seville, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"2019091009484500000_bhy323C1","first-page":"365","article-title":"microRNA (miRNA) speciation in Alzheimer\u2019s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)","volume":"3","author":"Alexandrov","year":"2012","journal-title":"Int J Biochem Mol Biol"},{"key":"2019091009484500000_bhy323C2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"2019091009484500000_bhy323C3","volume-title":"Executive functions and the frontal lobes: a lifespan perspective","author":"Anderson","year":"2008"},{"key":"2019091009484500000_bhy323C4","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.15252\/embj.201387576","article-title":"MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer\u2019s disease","volume":"33","author":"Banzhaf-Strathmann","year":"2014","journal-title":"EMBO J"},{"key":"2019091009484500000_bhy323C5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2019091009484500000_bhy323C6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/bmc-2016-0014","article-title":"Alzheimer\u2019s disease: presence and role of microRNAs","volume":"7","author":"Basavaraju","year":"2016","journal-title":"Biomol Concepts"},{"key":"2019091009484500000_bhy323C7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.neuroimage.2008.03.022","article-title":"Detection of focal changes in human cortical thickness: spherical wavelets versus Gaussian smoothing","volume":"41","author":"Bernal-Rusiel","year":"2008","journal-title":"Neuroimage"},{"key":"2019091009484500000_bhy323C8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuroimage.2010.03.074","article-title":"Determining the optimal level of smoothing in cortical thickness analysis: a hierarchical approach based on sequential statistical thresholding","volume":"52","author":"Bernal-Rusiel","year":"2010","journal-title":"Neuroimage"},{"key":"2019091009484500000_bhy323C9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mad.2015.03.006","article-title":"MARK-AGE biomarkers of ageing","volume":"151","author":"B\u00fcrkle","year":"2015","journal-title":"Mech Ageing Dev"},{"key":"2019091009484500000_bhy323C10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1017\/S1041610298005377","article-title":"Clinical validity and utility of the interview for deterioration of daily living in dementia for Spanish-speaking communities","volume":"10","author":"B\u00f6hm","year":"1998","journal-title":"Int Psychogeriatr"},{"key":"2019091009484500000_bhy323C11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neurobiolaging.2017.12.010","article-title":"Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer\u2019s disease","volume":"64","author":"Cantero","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2019091009484500000_bhy323C12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.acn.2007.08.010","article-title":"Assessment of executive functions: review of instruments and identification of critical issues","volume":"23","author":"Chan","year":"2008","journal-title":"Arch Clin Neuropsychol"},{"key":"2019091009484500000_bhy323C13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000356646","article-title":"Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat","volume":"33","author":"Che","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"2019091009484500000_bhy323C14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.neuron.2014.10.031","article-title":"Unbiased approaches to biomarker discovery in neurodegenerative diseases","volume":"84","author":"Chen-Plotkin","year":"2014","journal-title":"Neuron"},{"key":"2019091009484500000_bhy323C15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2174\/1871527314666150116123305","article-title":"MicroRNA landscape in Alzheimer\u2019s disease","volume":"14","author":"Cogoni","year":"2015","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2019091009484500000_bhy323C16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C17","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1007\/s12035-016-0088-8","article-title":"Plasma miR-34a-5p and miR-545-3p as early biomarkers of Alzheimer\u2019s disease: potential and limitations","volume":"54","author":"Cosin-Tomas","year":"2017","journal-title":"Mol Neurobiol"},{"key":"2019091009484500000_bhy323C18","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease","volume":"285","author":"Cui","year":"2010","journal-title":"J Biol Chem"},{"key":"2019091009484500000_bhy323C19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nn.3082","article-title":"microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons","volume":"15","author":"Dajas-Bailador","year":"2012","journal-title":"Nat Neurosci"},{"key":"2019091009484500000_bhy323C20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fmed.2017.00074","article-title":"microRNA in cardiovascular aging and age-related cardiovascular diseases","volume":"4","author":"De Lucia","year":"2017","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"2019091009484500000_bhy323C21","doi-asserted-by":"crossref","first-page":"e0126423","DOI":"10.1371\/journal.pone.0126423","article-title":"MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer\u2019s disease","volume":"10","author":"Denk","year":"2015","journal-title":"PLoS One"},{"key":"2019091009484500000_bhy323C22","doi-asserted-by":"crossref","first-page":"625659","DOI":"10.1155\/2015\/625659","article-title":"Serum microRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer\u2019s disease","volume":"2015","author":"Dong","year":"2015","journal-title":"Dis Markers"},{"key":"2019091009484500000_bhy323C23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphys.2015.00040","article-title":"The emerging role of microRNAs in Alzheimer\u2019s disease","volume":"6","author":"Femminella","year":"2015","journal-title":"Front Physiol"},{"key":"2019091009484500000_bhy323C24","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.neurobiolaging.2013.06.007","article-title":"Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand","volume":"34","author":"Fenn","year":"2013","journal-title":"Neurobiol Aging"},{"key":"2019091009484500000_bhy323C25","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091009484500000_bhy323C26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4","article-title":"High-resolution intersubject averaging and a coordinate system for the cortical surface","volume":"8","author":"Fischl","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"2019091009484500000_bhy323C27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2165\/00023210-200620020-00006","article-title":"Biological markers of age-related memory deficits: treatment of senescent physiology","volume":"20","author":"Foster","year":"2006","journal-title":"CNS Drugs"},{"key":"2019091009484500000_bhy323C28","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1038\/ncomms11106","article-title":"Diverse human extracellular RNAs are widely detected in human plasma","volume":"7","author":"Freedman","year":"2016","journal-title":"Nat Commun"},{"key":"2019091009484500000_bhy323C29","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3233\/JAD-140756","article-title":"Circulating miRNAs as potential biomarkers in Alzheimer\u2019s disease","volume":"42","author":"Galimberti","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","article-title":"Blood serum miRNA: non-invasive biomarkers for Alzheimer\u2019s disease","volume":"235","author":"Geekiyanage","year":"2012","journal-title":"Exp Neurol"},{"key":"2019091009484500000_bhy323C31","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1001\/jamaneurol.2016.2642","article-title":"Longitudinal \u03b2-amyloid deposition and hippocampal volume in preclinical Alzheimer disease and suspected non-Alzheimer disease pathophysiology","volume":"73","author":"Gordon","year":"2016","journal-title":"JAMA Neurol"},{"key":"2019091009484500000_bhy323C32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1532-5415.1998.tb01075.x","article-title":"Executive cognitive abilities and functional status among community-dwelling older persons in the San Luis Valley Health and Aging Study","volume":"46","author":"Grigsby","year":"1998","journal-title":"J Am Geriatr Soc"},{"key":"2019091009484500000_bhy323C33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/jhg.2016.150","article-title":"Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus","volume":"62","author":"Hashimoto","year":"2017","journal-title":"J Hum Genet"},{"key":"2019091009484500000_bhy323C34","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression","volume":"105","author":"Hebert","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091009484500000_bhy323C35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-122350","article-title":"A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer\u2019s disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls","volume":"35","author":"Hebert","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C36","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3233\/JAD-170156","article-title":"Identification of circulating miR-125b as a potential biomarker of Alzheimer\u2019s disease in APP\/PS1 transgenic mouse","volume":"59","author":"Hong","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S1474-4422(14)70194-2","article-title":"Age-specific population frequencies of cerebral \u03b2-amyloidosis and neurodegeneration among people with normal cognitive function aged 50\u201389 years: a cross-sectional study","volume":"13","author":"Jack","year":"2014","journal-title":"Lancet Neurol"},{"key":"2019091009484500000_bhy323C38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.lfs.2017.05.023","article-title":"miR-34a knockout attenuates cognitive deficits in APP\/PS1 mice through inhibition of the amyloidogenic processing of APP","volume":"182","author":"Jian","year":"2017","journal-title":"Life Sci"},{"key":"2019091009484500000_bhy323C39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jgg.2014.07.003","article-title":"Circulating miRNAs in ageing and ageing-related diseases","volume":"41","author":"Jung","year":"2014","journal-title":"J Genet Genomics"},{"key":"2019091009484500000_bhy323C40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-130932","article-title":"MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer\u2019s disease","volume":"39","author":"Kiko","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"2019091009484500000_bhy323C42","doi-asserted-by":"crossref","first-page":"e69807","DOI":"10.1371\/journal.pone.0069807","article-title":"Circulating miRNA biomarkers for Alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2013","journal-title":"PLoS One"},{"key":"2019091009484500000_bhy323C43","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.bbadis.2016.06.001","article-title":"Are circulating microRNAs peripheral biomarkers for Alzheimer\u2019s disease?","volume":"1862","author":"Kumar","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2019091009484500000_bhy323C44","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","article-title":"Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma","volume":"141","author":"Lawrie","year":"2008","journal-title":"Br J Haematol"},{"key":"2019091009484500000_bhy323C45","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol"},{"key":"2019091009484500000_bhy323C46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2019091009484500000_bhy323C47","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12031-017-0971-4","article-title":"MicroRNA expression in the locus coeruleus, entorhinal cortex, and hippocampus at early and middle stages of Braak neurofibrillary tangle pathology","volume":"63","author":"Llorens","year":"2017","journal-title":"J Mol Neurosci"},{"key":"2019091009484500000_bhy323C48","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"2019091009484500000_bhy323C49","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1053\/j.seminoncol.2011.08.006","article-title":"MicroRNAs in the pathogenesis of cancer","volume":"38","author":"Lovat","year":"2011","journal-title":"Semin Oncol"},{"key":"2019091009484500000_bhy323C50","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"J Biol Chem"},{"key":"2019091009484500000_bhy323C51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neulet.2017.09.043","article-title":"MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer\u2019s disease","volume":"661","author":"Ma","year":"2017","journal-title":"Neurosci Lett"},{"key":"2019091009484500000_bhy323C52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat Cell Biol"},{"key":"2019091009484500000_bhy323C53","doi-asserted-by":"crossref","first-page":"19879","DOI":"10.1038\/srep19879","article-title":"Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons","volume":"6","author":"Malmevik","year":"2016","journal-title":"Sci Rep"},{"key":"2019091009484500000_bhy323C54","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/jid.2014.89","article-title":"MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes","volume":"134","author":"Meisgen","year":"2014","journal-title":"J Invest Dermatol"},{"key":"2019091009484500000_bhy323C55","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091009484500000_bhy323C56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1128\/MCB.00589-15","article-title":"Regulation of neuronal cell cycle and apoptosis by microRNA 34a","volume":"36","author":"Modi","year":"2015","journal-title":"Mol Cell Biol"},{"key":"2019091009484500000_bhy323C57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-2010-091603","article-title":"MiR-107 is reduced in Alzheimer\u2019s disease brain neocortex: validation study","volume":"21","author":"Nelson","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C58","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1750-3639.2007.00120.x","article-title":"MicroRNAs (miRNAs) in neurodegenerative diseases","volume":"18","author":"Nelson","year":"2008","journal-title":"Brain Pathol"},{"key":"2019091009484500000_bhy323C59","doi-asserted-by":"crossref","first-page":"725","DOI":"10.18632\/aging.100603","article-title":"Age related changes in microRNA levels in serum","volume":"5","author":"Noren Hooten","year":"2013","journal-title":"Aging (Albany, NY)"},{"key":"2019091009484500000_bhy323C60","doi-asserted-by":"crossref","first-page":"e8898","DOI":"10.1371\/journal.pone.0008898","article-title":"Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer\u2019s disease cortex reveals altered miRNA regulation","volume":"5","author":"Nunez-Iglesias","year":"2010","journal-title":"PLoS One"},{"key":"2019091009484500000_bhy323C61","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.arr.2013.05.001","article-title":"MicroRNAs linking inflamm-aging, cellular senescence and cancer","volume":"12","author":"Olivieri","year":"2013","journal-title":"Ageing Res Rev"},{"key":"2019091009484500000_bhy323C62","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.neuroimage.2006.02.001","article-title":"Cortical surface-based analysis of 18F-FDG PET: measured metabolic abnormalities in schizophrenia are affected by cortical structural abnormalities","volume":"31","author":"Park","year":"2006","journal-title":"Neuroimage"},{"key":"2019091009484500000_bhy323C63","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1152\/physiolgenomics.00133.2016","article-title":"MiR-146a\/b: a family with shared seeds and different roots","volume":"49","author":"Paterson","year":"2017","journal-title":"Physiol Genomics"},{"key":"2019091009484500000_bhy323C64","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.180.8.5689","article-title":"Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells","volume":"180","author":"Perry","year":"2008","journal-title":"J Immunol"},{"key":"2019091009484500000_bhy323C65","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4137\/JEN.S32843","article-title":"Role of miRNA-9 in brain development","volume":"10","author":"Radhakrishnan","year":"2016","journal-title":"J Exp Neurosci"},{"key":"2019091009484500000_bhy323C66","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnagi.2017.00323","article-title":"miRNA in circulating microvesicles as biomarkers for age-related cognitive decline","volume":"9","author":"Rani","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"2019091009484500000_bhy323C67","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00019442-200502000-00007","article-title":"Attention and executive control predict Alzheimer\u2019s disease in late life: results from the Berlin Aging Study (BASE)","volume":"13","author":"Rapp","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"2019091009484500000_bhy323C68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2016.05.026","article-title":"Expression of microRNA-34a in Alzheimer\u2019s disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity","volume":"1646","author":"Sarkar","year":"2016","journal-title":"Brain Res"},{"key":"2019091009484500000_bhy323C69","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12031-011-9587-2","article-title":"Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-beta","volume":"46","author":"Schonrock","year":"2012","journal-title":"J Mol Neurosci"},{"key":"2019091009484500000_bhy323C70","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer\u2019s disease temporal lobe neocortex","volume":"459","author":"Sethi","year":"2009","journal-title":"Neurosci Lett"},{"key":"2019091009484500000_bhy323C71","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8722-6-6","article-title":"Diverse functions of miR-125 family in different cell contexts","volume":"6","author":"Sun","year":"2013","journal-title":"J Hematol Oncol"},{"key":"2019091009484500000_bhy323C72","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.mam.2012.07.018","article-title":"Epigenetics: the link between nature and nurture","volume":"34","author":"Tammen","year":"2013","journal-title":"Mol Aspects Med"},{"key":"2019091009484500000_bhy323C73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jns.2013.10.002","article-title":"Circulating miR-125b as a biomarker of Alzheimer\u2019s disease","volume":"336","author":"Tan","year":"2014","journal-title":"J Neurol Sci"},{"issue":"2","key":"2019091009484500000_bhy323C74","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/alzrt162","article-title":"Plasma amyloid beta measurements\u2014a desired but elusive Alzheimer\u2019s disease biomarker","volume":"5","author":"Toledo","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"2019091009484500000_bhy323C75","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00401-011-0861-8","article-title":"Factors affecting Abeta plasma levels and their utility as biomarkers in ADNI","volume":"122","author":"Toledo","year":"2011","journal-title":"Acta Neuropathol"},{"key":"2019091009484500000_bhy323C76","first-page":"392","article-title":"Biomarkes of aging","volume":"2","author":"Vasto","year":"2010","journal-title":"Front Biosci"},{"key":"2019091009484500000_bhy323C77","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","article-title":"MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins","volume":"13","author":"Vickers","year":"2011","journal-title":"Nat Cell Biol"},{"key":"2019091009484500000_bhy323C78","doi-asserted-by":"crossref","first-page":"2584940","DOI":"10.1155\/2016\/2584940","article-title":"Differential DNA methylation of microRNA genes in temporal cortex from Alzheimer\u2019s disease individuals","volume":"2016","author":"Villela","year":"2016","journal-title":"Neural Plast"},{"key":"2019091009484500000_bhy323C79","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-010-0756-0","article-title":"Patterns of microRNA expression in normal and early Alzheimer\u2019s disease human temporal cortex: white matter versus gray matter","volume":"121","author":"Wang","year":"2011","journal-title":"Acta Neuropathol"},{"key":"2019091009484500000_bhy323C80","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.brainresbull.2009.08.006","article-title":"miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer\u2019s disease, inhibits bcl2 translation","volume":"80","author":"Wang","year":"2009","journal-title":"Brain Res Bull"},{"issue":"7","key":"2019091009484500000_bhy323C81","doi-asserted-by":"crossref","first-page":"e41561","DOI":"10.1371\/journal.pone.0041561","article-title":"Comparing the microRNA spectrum between serum and plasma","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"2019091009484500000_bhy323C82","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3233\/JAD-150619","article-title":"Circulating microRNAs as biomarkers of Alzheimer\u2019s disease: a systematic review","volume":"49","author":"Wu","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"2019091009484500000_bhy323C83","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1159\/000478919","article-title":"MiR-9 regulates the expression of BACE1 in dementia induced by chronic brain hypoperfusion in rats","volume":"42","author":"Xie","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2019091009484500000_bhy323C84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression scale: a preliminary report","volume":"17","author":"Yesavage","year":"1983","journal-title":"J Psychiatr Res"},{"key":"2019091009484500000_bhy323C85","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000375236","article-title":"Circulating biomarker panels in Alzheimer\u2019s disease","volume":"61","author":"Zafari","year":"2015","journal-title":"Gerontology"},{"key":"2019091009484500000_bhy323C86","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neurobiolaging.2018.09.011","article-title":"miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression","volume":"73","author":"Zhang","year":"2019","journal-title":"Neurobiol Aging"},{"key":"2019091009484500000_bhy323C87","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/gerona\/glu145","article-title":"Investigation of microRNA expression in human serum during the aging process","volume":"70","author":"Zhang","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/29\/10\/4426\/29955438\/bhy323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:24:19Z","timestamp":1662503059000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/29\/10\/4426\/5257443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,22]]},"references-count":87,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,12,22]]},"published-print":{"date-parts":[[2019,9,13]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhy323","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2018,12,22]]}}}