{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:44:16Z","timestamp":1775709856481,"version":"3.50.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI13\/01958"],"award-info":[{"award-number":["PI13\/01958"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI16\/00889"],"award-info":[{"award-number":["PI16\/00889"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We mapped alterations of the functional structure of the cerebral cortex using a novel imaging approach in a sample of 160 obsessive\u2013compulsive disorder (OCD) patients. Whole-brain functional connectivity maps were generated using multidistance measures of intracortical neural activity coupling defined within isodistant local areas. OCD patients demonstrated neural activity desynchronization within the orbitofrontal cortex and in primary somatosensory, auditory, visual, gustatory, and olfactory areas. Symptom severity was significantly associated with the degree of functional structure alteration in OCD-relevant brain regions. By means of a novel imaging perspective, we once again identified brain alterations in the orbitofrontal cortex, involving areas purportedly implicated in the pathophysiology of OCD. However, our results also indicated that weaker intracortical activity coupling is also present in each primary sensory area. On the basis of previous neurophysiological studies, such cortical activity desynchronization may best be interpreted as reflecting deficient inhibitory neuron activity and altered sensory filtering.<\/jats:p>","DOI":"10.1093\/cercor\/bhz008","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T12:10:21Z","timestamp":1547208621000},"page":"4753-4762","source":"Crossref","is-referenced-by-count":23,"title":["Mapping Alterations of the Functional Structure of the Cerebral Cortex in Obsessive\u2013Compulsive Disorder"],"prefix":"10.1093","volume":"29","author":[{"given":"Jesus","family":"Pujol","sequence":"first","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM, Barcelona, 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben J","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Mart\u00ednez-Vilavella","sequence":"additional","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Deus","sequence":"additional","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain"},{"name":"Department of Clinical and Health Psychology, Autonomous University of Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M","family":"Mench\u00f3n","sequence":"additional","affiliation":[{"name":"Centro 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