{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:12:26Z","timestamp":1782328346654,"version":"3.54.5"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5R01MH112189"],"award-info":[{"award-number":["5R01MH112189"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5R01MH108590"],"award-info":[{"award-number":["5R01MH108590"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Schizophrenia (SCZ) is recognized as a disorder of distributed brain dysconnectivity. While progress has been made delineating large-scale functional networks in SCZ, little is known about alterations in grey matter integrity of these networks. We used a multivariate approach to identify the structural covariance of the salience, default, motor, visual, fronto-parietal control, and dorsal attention networks. We derived individual scores reflecting covariance in each structural image for a given network. Seed-based multivariate analyses were conducted on structural images in a discovery (n\u2009=\u200990) and replication (n\u2009=\u200974) sample of SCZ patients and healthy controls. We first validated patterns across all networks, consistent with well-established functional connectivity reports. Next, across two SCZ samples, we found reliable and robust reductions in structural integrity of the fronto-parietal control and salience networks, but not default, dorsal attention, motor and sensory networks. Well-powered exploratory analyses failed to identify relationships with symptoms. These findings provide evidence of selective structural decline in associative networks in SCZ. Such decline may be linked with recently identified functional disturbances in associative networks, providing more sensitive multi-modal network-level probes in SCZ. Absence of symptom effects suggests that identified disturbances may underlie a trait-type marker in SCZ.<\/jats:p>","DOI":"10.1093\/cercor\/bhz064","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T15:11:07Z","timestamp":1554131467000},"page":"5269-5284","source":"Crossref","is-referenced-by-count":34,"title":["Structural Covariance Reveals Alterations in Control and Salience Network Integrity in Chronic Schizophrenia"],"prefix":"10.1093","volume":"29","author":[{"given":"R Nathan","family":"Spreng","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"},{"name":"Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"DuPre","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-9070","authenticated-orcid":false,"given":"Jie Lisa","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mount Sinai School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Diehl","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California at Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Murray","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey D","family":"Pearlson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Department of Psychology, Yale University, CT, USA"},{"name":"Center for Neural Science, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Anticevic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA"},{"name":"Department of Psychology, Yale University, CT, USA"},{"name":"Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"2019121808473202400_ref1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrn3465","article-title":"Imaging structural co-variance between human brain regions","volume":"14","author":"Alexander-Bloch","year":"2013","journal-title":"Nature reviews Neuroscience"},{"key":"2019121808473202400_ref2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cercor\/bhr388","article-title":"The anatomical distance of functional connections predicts brain network topology in health and schizophrenia","volume":"23","author":"Alexander-Bloch","year":"2013","journal-title":"Cereb Cortex"},{"key":"2019121808473202400_ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2009.08.040","article-title":"Antipsychotic dose equivalents and dose-years: A standardized method for comparing exposure to different 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