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In the present manuscript, we examined the development of GABAergic circuits in the primary visual cortex of Mecp2-deficient mice. We identified that PV circuits were the only GABAergic interneurons to be upregulated, while other interneurons were downregulated. Acceleration of PV cell maturation was accompanied by increased PV cells engulfment by perineuronal nets (PNNs) and by an increase of PV cellular and PNN structural complexity. Interestingly, selective deletion of Mecp2 from PV cells was sufficient to drive increased structure complexity of PNN. Moreover, the accelerated PV and PNN maturation was recapitulated in organotypic cultures. Our results identify a specific timeline of disruption of GABAergic circuits in the absence of Mecp2, indicating a possible cell-autonomous role of MeCP2 in the formation of PV cellular arbors and PNN structures in the visual cortex.<\/jats:p>","DOI":"10.1093\/cercor\/bhz085","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T07:09:29Z","timestamp":1554793769000},"page":"256-268","source":"Crossref","is-referenced-by-count":46,"title":["Accelerated Hyper-Maturation of Parvalbumin Circuits in the Absence of MeCP2"],"prefix":"10.1093","volume":"30","author":[{"given":"Annarita","family":"Patrizi","sequence":"first","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Schaller Research Group Leader at the German Cancer Research Center (DKFZ), Heildeberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia N","family":"Awad","sequence":"first","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidisha","family":"Chattopadhyaya","sequence":"first","affiliation":[{"name":"CHU Ste Justine Research Center, Montreal, QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Li","sequence":"first","affiliation":[{"name":"F.M. 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