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Few studies have examined how prenatal stress (PS) regulates the sensorimotor gating during the lifespan and how PS modifies the development of amyloid-beta (A\u03b2) pathology in brain areas underlying the PPI formation. We followed alternations in corticosterone levels, learning and memory, and the PPI of the ASR measures in APPNL-G-F\/NL-G-F offspring of dams exposed to gestational noise stress. In-depth quantifications of the A\u03b2 plaque accumulation were also performed at 6 months. The results indicated an age-dependent deterioration of sensorimotor gating, long-lasting PS-induced abnormalities in PPI magnitudes, as well as deficits in spatial memory. The PS also resulted in a higher A\u03b2 aggregation predominantly in brain areas associated with the PPI modulation network. The findings suggest the contribution of a PS-induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in regulating the PPI modulation substrates leading to the abnormal development of the neural protection system in response to disruptive stimuli. The long-lasting HPA axis dysregulation appears to be the major underlying mechanism in precipitating the A\u03b2 deposition, especially in brain areas contributed to the PPI modulation network.<\/jats:p>","DOI":"10.1093\/cercor\/bhz089","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T07:13:00Z","timestamp":1554880380000},"page":"311-325","source":"Crossref","is-referenced-by-count":8,"title":["\u00a0Life-Course Contribution of Prenatal Stress in Regulating the Neural Modulation Network Underlying the Prepulse Inhibition of the Acoustic Startle Reflex in Male Alzheimer\u2019s Disease Mice"],"prefix":"10.1093","volume":"30","author":[{"given":"Zahra","family":"Jafari","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada"},{"name":"Department of Basic Sciences in Rehabilitation, School of Rehabilitation Sciences, Iran University of Medical Science, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan E","family":"Kolb","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid H","family":"Mohajerani","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"2020021907395098400_ref1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/026988119801200402","article-title":"Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls","volume":"12","author":"Abel","year":"1998","journal-title":"J 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