{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:38Z","timestamp":1753875998208,"version":"3.41.2"},"reference-count":84,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["RYC-2016-20414","SAF2014-58598-JIN","BFU201563769-R","SAF2017-86983-R","PCIN-2016-095","SAF2015-62540-ERC","SAF2016-78071-R","BES-2011-043464"],"award-info":[{"award-number":["RYC-2016-20414","SAF2014-58598-JIN","BFU201563769-R","SAF2017-86983-R","PCIN-2016-095","SAF2015-62540-ERC","SAF2016-78071-R","BES-2011-043464"]}]},{"DOI":"10.13039\/501100011698","name":"Junta de Comunidades de Castilla\u2013La Mancha","doi-asserted-by":"publisher","award":["PPII2014-005-P"],"award-info":[{"award-number":["PPII2014-005-P"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003451","name":"University of the Basque Country","doi-asserted-by":"publisher","award":["EHUrOPE14\/03"],"award-info":[{"award-number":["EHUrOPE14\/03"]}],"id":[{"id":"10.13039\/501100003451","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basque Ministry of Health","award":["ELKARTEK","RIS3"],"award-info":[{"award-number":["ELKARTEK","RIS3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Phosphatase and tensin homolog on chromosome 10 (PTEN) is a tumor suppressor and autism-associated gene that exerts an important influence over neuronal structure and function during development. In addition, it participates in synaptic plasticity processes in adulthood. As an attempt to assess synaptic and developmental mechanisms by which PTEN can modulate cognitive function, we studied the consequences of 2 different genetic manipulations in mice: presence of additional genomic copies of the Pten gene (Ptentg) and knock-in of a truncated Pten gene lacking its PDZ motif (Pten-\u0394PDZ), which is required for interaction with synaptic proteins. Ptentg mice exhibit substantial microcephaly, structural hypoconnectivity, enhanced synaptic depression at cortico-amygdala synapses, reduced anxiety, and intensified social interactions. In contrast, Pten-\u0394PDZ mice have a much more restricted phenotype, with normal synaptic connectivity, but impaired synaptic depression at cortico-amygdala synapses and virtually abolished social interactions. These results suggest that synaptic actions of PTEN in the amygdala contribute to specific behavioral traits, such as sociability. Also, PTEN appears to function as a bidirectional rheostat in the amygdala: reduction in PTEN activity at synapses is associated with less sociability, whereas enhanced PTEN activity accompanies hypersocial behavior.<\/jats:p>","DOI":"10.1093\/cercor\/bhz103","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:17:20Z","timestamp":1557159440000},"source":"Crossref","is-referenced-by-count":7,"title":["PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior"],"prefix":"10.1093","author":[{"given":"Cristina","family":"S\u00e1nchez-Puelles","sequence":"first","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"},{"name":"Department of Molecular Neurobiology, Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC\/Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Calleja-Felipe","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ouro","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassen","family":"Bougamra","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibai","family":"Diez","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Laboratory, Biocruces Health Research Institute, 48903 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-2184","authenticated-orcid":false,"given":"Asier","family":"Erramuzpe","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Laboratory, Biocruces Health Research Institute, 48903 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Laboratory, Biocruces Health Research Institute, 48903 Barakaldo, Spain"},{"name":"Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mart\u00ednez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology, Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC\/Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-3495","authenticated-orcid":false,"given":"C\u00e9sar","family":"Venero","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, Universidad Nacional de Educaci\u00f3n a Distancia, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Morales","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Esteban","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology, Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC\/Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Knafo","sequence":"additional","affiliation":[{"name":"Molecular Cognition Laboratory, Biophysics Institute, Consejo Superior de Investigaciones Cientificas (CSIC)-University of the Basque Country (UPV)\/Euskal Herriko University (EHU), Campus Universidad del Pa\u00eds Vasco, 48940 Leioa, Spain"},{"name":"Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain"},{"name":"Department of Physiology and Cell Biology and National Institute of Biotechnology in the Negev, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 8410501 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"2019100104320165500_ref1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.pnpbp.2017.07.028","article-title":"Synaptic dysfunction in amygdala in intellectual disorder 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