{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:35:29Z","timestamp":1790228129563,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 EY021579"],"award-info":[{"award-number":["NIH R01 EY021579"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH F31 EY025532"],"award-info":[{"award-number":["NIH F31 EY025532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prior knowledge about our environment influences our actions. How does this knowledge evolve into a final action plan and how does the brain represent this? Here, we investigated this question in the monkey oculomotor system during self-guided search of natural scenes. In the frontal eye field (FEF), we found a subset of neurons, \u201cEarly neurons,\u201d that contain information about the upcoming saccade long before it is executed, often before the previous saccade had even ended. Crucially, much of this early information did not relate to the actual saccade that would eventually be selected. Rather, it related to prior information about the probabilities of possible upcoming saccades based on the presaccade fixation location. Nearer to the time of saccade onset, a greater proportion of these neurons\u2019 activities related to the saccade selection, although prior information continued to influence activity throughout. A separate subset of FEF neurons, \u201cLate neurons,\u201d only represented the final action plan near saccade onset and not prior information. Our results demonstrate how, across the population of FEF neurons, prior information evolves into definitive saccade plans.<\/jats:p>","DOI":"10.1093\/cercor\/bhz216","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T07:38:27Z","timestamp":1566805107000},"page":"1957-1973","source":"Crossref","is-referenced-by-count":5,"title":["From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-115X","authenticated-orcid":false,"given":"Joshua I","family":"Glaser","sequence":"first","affiliation":[{"name":"Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan Ability Lab, Northwestern University, Chicago, IL, USA"},{"name":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Statistics, Columbia University, New York, NY, USA"},{"name":"Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Northwestern University, Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N","family":"Lawlor","sequence":"first","affiliation":[{"name":"Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan Ability Lab, Northwestern University, Chicago, IL, USA"},{"name":"Division of Neurology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Segraves","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Northwestern 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