{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:05:25Z","timestamp":1774598725262,"version":"3.50.1"},"reference-count":117,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-EY023037-05"],"award-info":[{"award-number":["R01-EY023037-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NEI K99-EY029326-01"],"award-info":[{"award-number":["NEI K99-EY029326-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Picower Institute Innovation Fund"},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary visual cortex (V1) is the locus of numerous forms of experience-dependent plasticity. Restricting visual stimulation to one eye at a time has revealed that many such forms of plasticity are eye-specific, indicating that synaptic modification occurs prior to binocular integration of thalamocortical inputs. A common feature of these forms of plasticity is the requirement for NMDA receptor (NMDAR) activation in V1. We therefore hypothesized that NMDARs in cortical layer 4 (L4), which receives the densest thalamocortical input, would be necessary for all forms of NMDAR-dependent and input-specific V1 plasticity. We tested this hypothesis in awake mice using a genetic approach to selectively delete NMDARs from L4 principal cells. We found, unexpectedly, that both stimulus-selective response potentiation and potentiation of open-eye responses following monocular deprivation (MD) persist in the absence of L4 NMDARs. In contrast, MD-driven depression of deprived-eye responses was impaired in mice lacking L4 NMDARs, as was L4 long-term depression in V1 slices. Our findings reveal a crucial requirement for L4 NMDARs in visual cortical synaptic depression, and a surprisingly negligible role for them in cortical response potentiation. These results demonstrate that NMDARs within distinct cellular subpopulations support different forms of experience-dependent plasticity.<\/jats:p>","DOI":"10.1093\/cercor\/bhz260","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:28:15Z","timestamp":1570562895000},"page":"2555-2572","source":"Crossref","is-referenced-by-count":32,"title":["Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity"],"prefix":"10.1093","volume":"30","author":[{"given":"Ming-fai","family":"Fong","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Sb","family":"Finnie","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taekeun","family":"Kim","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurore","family":"Thomazeau","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan S","family":"Kaplan","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel F","family":"Cooke","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Maurice Wohl Institute for Clinical Neuroscience, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK"},{"name":"The Medical Research Council Centre for Neurodevelopmental Disorders (MRC CNDD), King's College London, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark F","family":"Bear","sequence":"first","affiliation":[{"name":"Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"2020042203461404500_ref1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1126\/science.8511592","article-title":"Rapid remodeling of axonal arbors in the visual cortex","volume":"260","author":"Antonini","year":"1993","journal-title":"Science"},{"key":"2020042203461404500_ref2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.5665\/sleep.3830","article-title":"Sleep promotes cortical response potentiation following visual experience","volume":"37","author":"Aton","year":"2014","journal-title":"Sleep"},{"key":"2020042203461404500_ref3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1523\/JNEUROSCI.10-03-00909.1990","article-title":"Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist","volume":"10","author":"Bear","year":"1990","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.1978.sp012498","article-title":"The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex","volume":"283","author":"Blakemore","year":"1978","journal-title":"J Physiol"},{"key":"2020042203461404500_ref5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"2020042203461404500_ref6","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuron.2014.02.021","article-title":"Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex","volume":"82","author":"Bortone","year":"2014","journal-title":"Neuron"},{"key":"2020042203461404500_ref7","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1126\/science.1124593","article-title":"Cortex is driven by weak but synchronously active thalamocortical synapses","volume":"312","author":"Bruno","year":"2006","journal-title":"Science"},{"key":"2020042203461404500_ref8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.21.1.149","article-title":"Cortical plasticity: from synapses to maps","volume":"21","author":"Buonomano","year":"1998","journal-title":"Annu Rev Neurosci"},{"key":"2020042203461404500_ref9","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1073\/pnas.0808104106","article-title":"The ratio of NR2A\/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex","volume":"106","author":"Cho","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnsys.2018.00040","article-title":"Sleep promotes, and sleep loss inhibits, selective changes in firing rate, response properties and functional connectivity of primary visual cortex neurons","volume":"12","author":"Clawson","year":"2018","journal-title":"Front Syst Neurosci"},{"key":"2020042203461404500_ref11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuroscience.2009.03.045","article-title":"Anatomical origins of ocular dominance in mouse primary visual cortex","volume":"161","author":"Coleman","year":"2009","journal-title":"Neuroscience"},{"key":"2020042203461404500_ref12","doi-asserted-by":"crossref","first-page":"9670","DOI":"10.1523\/JNEUROSCI.1248-10.2010","article-title":"Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex","volume":"30","author":"Coleman","year":"2010","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref13","doi-asserted-by":"crossref","first-page":"16304","DOI":"10.1523\/JNEUROSCI.4333-10.2010","article-title":"Visual experience induces long-term potentiation in the primary visual cortex","volume":"30","author":"Cooke","year":"2010","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref14","doi-asserted-by":"crossref","first-page":"20130284","DOI":"10.1098\/rstb.2013.0284","article-title":"How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex","volume":"369","author":"Cooke","year":"2014","journal-title":"Philos Trans R Soc Lond B, Biol Sci"},{"key":"2020042203461404500_ref15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nn.3920","article-title":"Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1","volume":"18","author":"Cooke","year":"2015","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/375325a0","article-title":"A critical period for long-term potentiation at thalamocortical synapses","volume":"375","author":"Crair","year":"1995","journal-title":"Nature"},{"key":"2020042203461404500_ref17","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.celrep.2017.11.049","article-title":"Infrabarrels are layer 6 circuit modules in the barrel cortex that link long-range inputs and outputs","volume":"21","author":"Crandall","year":"2017","journal-title":"Cell Rep"},{"key":"2020042203461404500_ref18","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1073\/pnas.0609596104","article-title":"Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex","volume":"104","author":"Crozier","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nn1861","article-title":"Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex","volume":"10","author":"Cruikshank","year":"2007","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref20","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1016\/j.visres.2004.09.004","article-title":"LTP and LTD vary with layer in rodent visual cortex","volume":"44","author":"Daw","year":"2004","journal-title":"Vision Res"},{"key":"2020042203461404500_ref21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/jn.1992.67.1.197","article-title":"Critical period for monocular deprivation in the cat visual cortex","volume":"67","author":"Daw","year":"1992","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1152\/jn.1999.81.1.204","article-title":"Injection of MK-801 affects ocular dominance shifts more than visual activity","volume":"81","author":"Daw","year":"1999","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1113\/jphysiol.1970.sp009023","article-title":"Consequences of monocular deprivation on visual behaviour in kittens","volume":"206","author":"Dews","year":"1970","journal-title":"J Physiol"},{"key":"2020042203461404500_ref24","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1073\/pnas.90.5.2082","article-title":"Experience-dependent plasticity in adult rat barrel cortex","volume":"90","author":"Diamond","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of fragile X syndrome in mice","volume":"56","author":"Dolen","year":"2007","journal-title":"Neuron"},{"key":"2020042203461404500_ref26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.neuro.27.070203.144152","article-title":"Neuronal circuits of the neocortex","volume":"27","author":"Douglas","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"2020042203461404500_ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/cne.901600302","article-title":"Receptive fields of single cells and topography in mouse visual cortex","volume":"160","author":"Drager","year":"1975","journal-title":"J Comp Neurol"},{"key":"2020042203461404500_ref28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/jn.1978.41.1.28","article-title":"Observations on monocular deprivation in mice","volume":"41","author":"Drager","year":"1978","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref29","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1073\/pnas.89.10.4363","article-title":"Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade","volume":"89","author":"Dudek","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref30","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0896-6273(00)80136-1","article-title":"Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition","volume":"16","author":"Dudek","year":"1996","journal-title":"Neuron"},{"key":"2020042203461404500_ref31","doi-asserted-by":"crossref","first-page":"10485","DOI":"10.1073\/pnas.1710613114","article-title":"Cortically coordinated NREM thalamocortical oscillations play an essential, instructive role in visual system plasticity","volume":"114","author":"Durkin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature09656","article-title":"Reversing pathological neural activity using targeted plasticity","volume":"470","author":"Engineer","year":"2011","journal-title":"Nature"},{"key":"2020042203461404500_ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.neuro.051508.135516","article-title":"Synaptic mechanisms for plasticity in neocortex","volume":"32","author":"Feldman","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"2020042203461404500_ref34","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/375482a0","article-title":"Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation","volume":"375","author":"Flor","year":"1995","journal-title":"Nature"},{"key":"2020042203461404500_ref35","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1073\/pnas.1613279113","article-title":"Rapid recovery from the effects of early monocular deprivation is enabled by temporary inactivation of the retinas","volume":"113","author":"Fong","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref36","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1523\/JNEUROSCI.09-07-02443.1989","article-title":"The location and function of NMDA receptors in cat and kitten visual cortex","volume":"9","author":"Fox","year":"1989","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref37","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.neuron.2004.12.003","article-title":"How monocular deprivation shifts ocular dominance in visual cortex of young mice","volume":"44","author":"Frenkel","year":"2004","journal-title":"Neuron"},{"key":"2020042203461404500_ref38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neuron.2006.06.026","article-title":"Instructive effect of visual experience in mouse visual cortex","volume":"51","author":"Frenkel","year":"2006","journal-title":"Neuron"},{"key":"2020042203461404500_ref39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/cne.901940206","article-title":"Radial organization of thalamic projections to the neocortex in the mouse","volume":"194","author":"Frost","year":"1980","journal-title":"J Comp Neurol"},{"key":"2020042203461404500_ref40","volume-title":"Memory in the cerebral cortex","author":"Fuster","year":"1995"},{"key":"2020042203461404500_ref41","doi-asserted-by":"crossref","first-page":"16797","DOI":"10.1073\/pnas.0806159105","article-title":"Delayed plasticity of inhibitory neurons in developing visual cortex","volume":"105","author":"Gandhi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref42","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1978.sp012164","article-title":"The rate of recovery of vision after early monocular deprivation in kittens","volume":"274","author":"Giffin","year":"1978","journal-title":"J Physiol"},{"key":"2020042203461404500_ref43","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.visres.2004.10.021","article-title":"The spatial localization deficit in visually deprived kittens","volume":"45","author":"Gingras","year":"2005","journal-title":"Vision Res"},{"key":"2020042203461404500_ref44","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev.psych.49.1.585","article-title":"Perceptual learning","volume":"49","author":"Goldstone","year":"1998","journal-title":"Ann Rev Psychol"},{"key":"2020042203461404500_ref45","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1523\/JNEUROSCI.16-10-03274.1996","article-title":"Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse","volume":"16","author":"Gordon","year":"1996","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2013.05.016","article-title":"Obligatory role for the immediate early gene NARP in critical period plasticity","volume":"79","author":"Gu","year":"2013","journal-title":"Neuron"},{"key":"2020042203461404500_ref47","volume-title":"The organization of behavior","author":"Hebb","year":"1949"},{"key":"2020042203461404500_ref48","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nn1100","article-title":"Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation","volume":"6","author":"Heynen","year":"2003","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nn1610","article-title":"Prior experience enhances plasticity in adult visual cortex","volume":"9","author":"Hofer","year":"2006","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref50","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1046\/j.1460-9568.2002.02002.x","article-title":"Metabotropic glutamate receptors mediate expression of LTP in slices of rat visual cortex","volume":"15","author":"Huemmeke","year":"2002","journal-title":"Eur J Neurosci"},{"key":"2020042203461404500_ref51","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/cercor\/bhr304","article-title":"Loss of visually driven synaptic responses in layer 4 regular-spiking neurons of rat visual cortex in absence of competing inputs","volume":"22","author":"Iurilli","year":"2012","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082044","article-title":"Preserved excitatory-inhibitory balance of cortical synaptic inputs following deprived eye stimulation after a saturating period of monocular deprivation in rats","volume":"8","author":"Iurilli","year":"2013","journal-title":"PLoS One"},{"key":"2020042203461404500_ref53","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/cercor\/bhv099","article-title":"Thalamocortical innervation pattern in mouse auditory and visual cortex: laminar and cell-type specificity","volume":"26","author":"Ji","year":"2016","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref54","doi-asserted-by":"crossref","first-page":"9648","DOI":"10.1523\/JNEUROSCI.2655-07.2007","article-title":"Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex","volume":"27","author":"Jiang","year":"2007","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref55","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1523\/JNEUROSCI.3760-16.2017","article-title":"Locomotion induces stimulus-specific response enhancement in adult visual cortex","volume":"37","author":"Kaneko","year":"2017","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref56","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuron.2008.04.023","article-title":"Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex","volume":"58","author":"Kaneko","year":"2008","journal-title":"Neuron"},{"key":"2020042203461404500_ref57","doi-asserted-by":"crossref","first-page":"17789","DOI":"10.1523\/JNEUROSCI.1500-13.2013","article-title":"Visual acuity development and plasticity in the absence of sensory experience","volume":"33","author":"Kang","year":"2013","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref58","doi-asserted-by":"crossref","first-page":"e11450","DOI":"10.7554\/eLife.11450","article-title":"Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity","volume":"5","author":"Kaplan","year":"2016","journal-title":"eLife"},{"key":"2020042203461404500_ref59","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuron.2010.04.012","article-title":"Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex","volume":"66","author":"Khibnik","year":"2010","journal-title":"Neuron"},{"key":"2020042203461404500_ref60","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1523\/JNEUROSCI.1325-14.2014","article-title":"Layer 6 corticothalamic neurons activate a cortical output layer, layer 5a","volume":"34","author":"Kim","year":"2014","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref61","first-page":"73","article-title":"Elementary forms of synaptic plasticity in the visual cortex","volume":"28","author":"Kirkwood","year":"1995","journal-title":"Biol Res"},{"key":"2020042203461404500_ref62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/375328a0","article-title":"Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience","volume":"375","author":"Kirkwood","year":"1995","journal-title":"Nature"},{"key":"2020042203461404500_ref63","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1126\/science.2443978","article-title":"Blockade of \"NMDA\" receptors disrupts experience-dependent plasticity of kitten striate cortex","volume":"238","author":"Kleinschmidt","year":"1987","journal-title":"Science"},{"key":"2020042203461404500_ref64","doi-asserted-by":"crossref","first-page":"15455","DOI":"10.1523\/JNEUROSCI.2595-14.2014","article-title":"Target-specific properties of thalamocortical synapses onto layer 4 of mouse primary visual cortex","volume":"34","author":"Kloc","year":"2014","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref65","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nn.4215","article-title":"Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex","volume":"19","author":"Kondo","year":"2016","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref66","doi-asserted-by":"crossref","first-page":"8810","DOI":"10.1523\/JNEUROSCI.4502-12.2013","article-title":"Synaptic and intrinsic homeostatic mechanisms cooperate to increase L2\/3 pyramidal neuron excitability during a late phase of critical period plasticity","volume":"33","author":"Lambo","year":"2013","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref67","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.73.1888.245","article-title":"Mass action in cerebral function","volume":"73","author":"Lashley","year":"1931","journal-title":"Science"},{"key":"2020042203461404500_ref68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature10674","article-title":"A disinhibitory microcircuit for associative fear learning in the auditory cortex","volume":"480","author":"Letzkus","year":"2011","journal-title":"Nature"},{"key":"2020042203461404500_ref69","doi-asserted-by":"crossref","first-page":"9353","DOI":"10.1523\/JNEUROSCI.0334-17.2017","article-title":"Brief novel visual experience fundamentally changes synaptic plasticity in the mouse visual cortex","volume":"37","author":"Li","year":"2017","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref70","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref71","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nn.2508","article-title":"Loss of arc renders the visual cortex impervious to the effects of sensory experience or deprivation","volume":"13","author":"McCurry","year":"2010","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref72","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1140263","article-title":"Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network","volume":"317","author":"McHugh","year":"2007","journal-title":"Science"},{"key":"2020042203461404500_ref73","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/hipo.20684","article-title":"CA3 NMDA receptors are required for the rapid formation of a salient contextual representation","volume":"19","author":"McHugh","year":"2009","journal-title":"Hippocampus"},{"key":"2020042203461404500_ref74","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1073\/pnas.86.13.5183","article-title":"Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors","volume":"86","author":"Miller","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref75","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1152\/jn.1989.62.1.185","article-title":"Chronic recordings from single sites of kitten striate cortex during experience-dependent modifications of receptive-field properties","volume":"62","author":"Mioche","year":"1989","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1098\/rstb.1991.0060","article-title":"The long-term effectiveness of different regimens of occlusion on recovery from early monocular deprivation in kittens","volume":"333","author":"Mitchell","year":"1991","journal-title":"Philos Trans Roy Soc Lond B, Biol Sci"},{"key":"2020042203461404500_ref77","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1152\/physrev.1985.65.1.37","article-title":"Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena","volume":"65","author":"Mitzdorf","year":"1985","journal-title":"Physiol Rev"},{"key":"2020042203461404500_ref78","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2007.05.028","article-title":"Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity","volume":"54","author":"Mrsic-Flogel","year":"2007","journal-title":"Neuron"},{"key":"2020042203461404500_ref79","doi-asserted-by":"crossref","first-page":"10340","DOI":"10.1073\/pnas.95.17.10340","article-title":"Reorganization of auditory cortex in tinnitus","volume":"95","author":"Muhlnickel","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref80","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0042-6989(91)90116-M","article-title":"Vernier acuity of normal and visually deprived cats","volume":"31","author":"Murphy","year":"1991","journal-title":"Vision Res"},{"key":"2020042203461404500_ref81","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/307462a0","article-title":"Magnesium gates glutamate-activated channels in mouse central neurones","volume":"307","author":"Nowak","year":"1984","journal-title":"Nature"},{"key":"2020042203461404500_ref82","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1101\/lm.75304","article-title":"A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB","volume":"11","author":"Pham","year":"2004","journal-title":"Learn Mem"},{"key":"2020042203461404500_ref83","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1016\/S0042-6989(99)00022-X","article-title":"The visual physiology of the wild type mouse determined with pattern VEPs","volume":"39","author":"Porciatti","year":"1999","journal-title":"Vision Res"},{"key":"2020042203461404500_ref84","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1460-9568.2003.02420.x","article-title":"Developmental plasticity of mouse visual acuity","volume":"17","author":"Prusky","year":"2003","journal-title":"Eur J Neurosci"},{"key":"2020042203461404500_ref85","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1046\/j.1460-9568.2000.00236.x","article-title":"Experience-dependent plasticity of visual acuity in rats","volume":"12","author":"Prusky","year":"2000","journal-title":"Eur J Neurosci"},{"key":"2020042203461404500_ref86","doi-asserted-by":"crossref","first-page":"368","DOI":"10.7861\/clinmedicine.5-4-368","article-title":"Plasticity and functional recovery in neurology","volume":"5","author":"Ramachandran","year":"2005","journal-title":"Clin Med (Lond)"},{"key":"2020042203461404500_ref87","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuron.2014.04.035","article-title":"Network plasticity in adaptive filtering and behavioral habituation","volume":"82","author":"Ramaswami","year":"2014","journal-title":"Neuron"},{"key":"2020042203461404500_ref88","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/01677060801893300","article-title":"Habituation: the foundation of learning and attention, international workshop on habituation, Vancouver, August 15-18, 2007","volume":"22","author":"Rankin","year":"2008","journal-title":"J Neurogenet"},{"key":"2020042203461404500_ref89","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1073\/pnas.1112204109","article-title":"Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity","volume":"109","author":"Ranson","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref90","doi-asserted-by":"crossref","first-page":"15220","DOI":"10.1523\/JNEUROSCI.2078-13.2013","article-title":"The role of GluA1 in ocular dominance plasticity in the mouse visual cortex","volume":"33","author":"Ranson","year":"2013","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref91","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/jn.1998.80.3.1021","article-title":"Suppression of NMDA receptor function using antisense DNA block ocular dominance plasticity while preserving visual responses","volume":"80","author":"Roberts","year":"1998","journal-title":"J Neurophysiol"},{"issue":"39","key":"2020042203461404500_ref92","doi-asserted-by":"crossref","first-page":"7664","DOI":"10.1523\/JNEUROSCI.2117-18.2019","article-title":"Disruption of NMDA receptor function prevents normal experience-dependent homeostatic synaptic plasticity in mouse primary visual cortex","volume":"39","author":"Rodriguez","year":"2019","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref93","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/cercor\/bhx029","article-title":"Beta-catenin in the adult visual cortex regulates NMDA-receptor function and visual responses","volume":"28","author":"Saiepour","year":"2018","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref94","doi-asserted-by":"crossref","first-page":"10125","DOI":"10.1523\/JNEUROSCI.1484-17.2017","article-title":"Contralateral bias of high spatial frequency tuning and cardinal direction selectivity in mouse visual cortex","volume":"37","author":"Salinas","year":"2017","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref95","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1523\/JNEUROSCI.2451-08.2008","article-title":"Distinctive features of adult ocular dominance plasticity","volume":"28","author":"Sato","year":"2008","journal-title":"J Neurosci"},{"key":"2020042203461404500_ref96","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0896-6273(03)00323-4","article-title":"NMDA receptor-dependent ocular dominance plasticity in adult visual cortex","volume":"38","author":"Sawtell","year":"2003","journal-title":"Neuron"},{"key":"2020042203461404500_ref97","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1073\/pnas.1119527109","article-title":"Different glutamate receptors convey feedforward and recurrent processing in macaque V1","volume":"109","author":"Self","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref98","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1073\/pnas.1512878112","article-title":"Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex","volume":"112","author":"Sidorov","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref99","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/cercor\/bhr158","article-title":"Inhibition of matrix metalloproteinases prevents the potentiation of nondeprived-eye responses after monocular deprivation in juvenile rats","volume":"22","author":"Spolidoro","year":"2012","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref100","doi-asserted-by":"crossref","first-page":"11631","DOI":"10.1523\/JNEUROSCI.0545-14.2014","article-title":"Plasticity of binocularity and visual acuity are differentially limited by nogo receptor","volume":"34","author":"Stephany","year":"2014","journal-title":"J Neurosci"},{"issue":"1914\u20131923","key":"2020042203461404500_ref101","article-title":"Distinct circuits for recovery of eye dominance and acuity in murine amblyopia","volume":"28","author":"Stephany","year":"2018","journal-title":"Curr Biol"},{"key":"2020042203461404500_ref102","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nn1410","article-title":"Multiple periods of functional ocular dominance plasticity in mouse visual cortex","volume":"8","author":"Tagawa","year":"2005","journal-title":"Nat Neurosci"},{"key":"2020042203461404500_ref103","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neuron.2014.09.036","article-title":"Modeling the dynamic interaction of Hebbian and homeostatic plasticity","volume":"84","author":"Toyoizumi","year":"2014","journal-title":"Neuron"},{"key":"2020042203461404500_ref104","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0092-8674(00)81826-7","article-title":"Subregion- and cell type-restricted gene knockout in mouse brain","volume":"87","author":"Tsien","year":"1996","journal-title":"Cell"},{"key":"2020042203461404500_ref105","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0092-8674(00)81827-9","article-title":"The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory","volume":"87","author":"Tsien","year":"1996","journal-title":"Cell"},{"key":"2020042203461404500_ref106","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/327513a0","article-title":"NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats","volume":"327","author":"Tsumoto","year":"1987","journal-title":"Nature"},{"key":"2020042203461404500_ref107","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuron.2014.09.026","article-title":"The stimulus selectivity and connectivity of layer six principal cells reveals cortical microcircuits underlying visual processing","volume":"84","author":"Velez-Fort","year":"2014","journal-title":"Neuron"},{"key":"2020042203461404500_ref108","first-page":"727","article-title":"Histological studies of the visual system in monkeys with experimental amblyopia","volume":"12","author":"von Noorden","year":"1973","journal-title":"Invest Ophthalmol"},{"key":"2020042203461404500_ref109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-8993(03)03321-3","article-title":"Long term potentiation varies with layer in rat visual cortex","volume":"989","author":"Wang","year":"2003","journal-title":"Brain Res"},{"key":"2020042203461404500_ref110","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1444-0938.2005.tb05102.x","article-title":"Amblyopia: prevalence, natural history, functional effects and treatment","volume":"88","author":"Webber","year":"2005","journal-title":"Clin Exp Optom"},{"key":"2020042203461404500_ref111","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/cercor\/bhi098","article-title":"Layer 6 cortico-thalamic pyramidal cells preferentially innervate interneurons and generate facilitating EPSPs","volume":"16","author":"West","year":"2006","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","article-title":"Single-cell responses in striate cortex of kittens deprived of vision in one eye","volume":"26","author":"Wiesel","year":"1963","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref113","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/cercor\/9.3.264","article-title":"Representational plasticity in cortical area 3b paralleling tactual-motor skill acquisition in adult monkeys","volume":"9","author":"Xerri","year":"1999","journal-title":"Cereb Cortex"},{"key":"2020042203461404500_ref114","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/srep00203","article-title":"The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity","volume":"1","author":"Yang","year":"2011","journal-title":"Sci Rep"},{"key":"2020042203461404500_ref115","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1073\/pnas.0901305106","article-title":"Essential role for a long-term depression mechanism in ocular dominance plasticity","volume":"106","author":"Yoon","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020042203461404500_ref116","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1152\/jn.00974.2005","article-title":"Local connections to specific types of layer 6 neurons in the rat visual cortex","volume":"95","author":"Zarrinpar","year":"2006","journal-title":"J Neurophysiol"},{"key":"2020042203461404500_ref117","first-page":"2013","volume-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2019"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/4\/2555\/33111965\/bhz260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/4\/2555\/33111965\/bhz260.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T07:49:50Z","timestamp":1587541790000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/30\/4\/2555\/5673784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":117,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12,12]]},"published-print":{"date-parts":[[2020,4,14]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhz260","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2019,12,12]]}}}