{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:32:57Z","timestamp":1776357177582,"version":"3.51.2"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"State of Arizona, DHS"},{"DOI":"10.13039\/100007049","name":"McKnight Brain Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 AG055263"],"award-info":[{"award-number":["F31 AG055263"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AG050548"],"award-info":[{"award-number":["RO1 AG050548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deficits in auditory function and cognition are hallmarks of normative aging. Recent evidence suggests that hearing-impaired individuals have greater risks of developing cognitive impairment and dementia compared to people with intact auditory function, although the neurobiological bases underlying these associations are poorly understood. Here, a colony of aging macaques completed a battery of behavioral tests designed to probe frontal and temporal lobe-dependent cognition. Auditory brainstem responses (ABRs) and visual evoked potentials were measured to assess auditory and visual system function. Structural and diffusion magnetic resonance imaging were then performed to evaluate the microstructural condition of multiple white matter tracts associated with cognition. Animals showing higher cognitive function had significantly better auditory processing capacities, and these associations were selectively observed with tasks that primarily depend on temporal lobe brain structures. Tractography analyses revealed that the fractional anisotropy (FA) of the fimbria-fornix and hippocampal commissure were associated with temporal lobe-dependent visual discrimination performance and auditory sensory function. Conversely, FA of frontal cortex-associated white matter was not associated with auditory processing. Visual sensory function was not associated with frontal or temporal lobe FA, nor with behavior. This study demonstrates significant and selective relationships between ABRs, white matter connectivity, and higher-order cognitive ability.<\/jats:p>","DOI":"10.1093\/cercor\/bhz275","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T07:18:35Z","timestamp":1576221515000},"page":"2789-2803","source":"Crossref","is-referenced-by-count":6,"title":["Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques"],"prefix":"10.1093","volume":"30","author":[{"given":"Daniel T","family":"Gray","sequence":"first","affiliation":[{"name":"Division of Neural System, Memory and Aging"},{"name":"Evelyn F. McKnight Brain Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavanya","family":"Umapathy","sequence":"first","affiliation":[{"name":"Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M","family":"De La Pe\u00f1a","sequence":"first","affiliation":[{"name":"Division of Neural System, Memory and Aging"},{"name":"Evelyn F. McKnight Brain Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara N","family":"Burke","sequence":"first","affiliation":[{"name":"Evelyn F. McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R","family":"Engle","sequence":"first","affiliation":[{"name":"Division of Neural System, Memory and Aging"},{"name":"Evelyn F. McKnight Brain Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore P","family":"Trouard","sequence":"first","affiliation":[{"name":"Evelyn F. McKnight Brain Institute"},{"name":"Department of Biomedical Engineering"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-9007","authenticated-orcid":false,"given":"Carol A","family":"Barnes","sequence":"first","affiliation":[{"name":"Division of Neural System, Memory and Aging"},{"name":"Evelyn F. McKnight Brain Institute"},{"name":"Departments of Psychology, Neurology and Neuroscience, University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"issue":"4","key":"2020050409375278400_ref1","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1523\/JNEUROSCI.3160-14.2015","article-title":"Neural correlates of object-associated choice behavior in the perirhinal cortex of rats","volume":"35","author":"Ahn","year":"2015","journal-title":"J Neurosci."},{"issue":"1","key":"2020050409375278400_ref2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0013-4694(78)90341-3","article-title":"Auditory brain stem potentials in monkey (M. mulatta) and man","volume":"45","author":"Allen","year":"1978","journal-title":"Electroencephalogr Clin Neurophysiol."},{"issue":"Supplement C","key":"2020050409375278400_ref3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.neuroimage.2015.07.067","article-title":"Non-parametric representation and prediction of single- and multi-shell diffusion-weighted MRI data using Gaussian processes","volume":"122","author":"Andersson","year":"2015","journal-title":"NeuroImage"},{"issue":"3","key":"2020050409375278400_ref4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12021-014-9258-x","article-title":"The scalable brain Atlas: instant web-based access to public brain atlases and related content","volume":"13","author":"Bakker","year":"2015","journal-title":"Neuroinformatics."},{"issue":"10","key":"2020050409375278400_ref5","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1523\/JNEUROSCI.5171-06.2007","article-title":"Perceptual functions of perirhinal cortex in rats: zero-delay object recognition and simultaneous oddity discriminations","volume":"27","author":"Bartko","year":"2007","journal-title":"J Neurosci Off J Soc Neurosci."},{"issue":"6","key":"2020050409375278400_ref6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1046\/j.0953-816x.2001.01491.x","article-title":"Impairments in visual discrimination learning and recognition memory produced by neurotoxic lesions of rhinal cortex in rhesus monkeys","volume":"13","author":"Baxter","year":"2001","journal-title":"Eur J Neurosci."},{"issue":"11","key":"2020050409375278400_ref7","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1523\/JNEUROSCI.20-11-04311.2000","article-title":"Control of response selection by Reinforcer value requires interaction of amygdala and orbital prefrontal cortex","volume":"20","author":"Baxter","year":"2000","journal-title":"J Neurosci."},{"issue":"6","key":"2020050409375278400_ref8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1101\/lm.32100","article-title":"Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex","volume":"7","author":"Buffalo","year":"2000","journal-title":"Learn Mem Cold Spring Harb N."},{"issue":"1","key":"2020050409375278400_ref9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrn1809","article-title":"Neural plasticity in the ageing brain","volume":"7","author":"Burke","year":"2006","journal-title":"Nat Rev Neurosci."},{"issue":"30","key":"2020050409375278400_ref10","doi-asserted-by":"publisher","first-page":"9905","DOI":"10.1523\/JNEUROSCI.3918-13.2014","article-title":"Orbitofrontal cortex volume in area 11\/13 predicts reward devaluation, but not reversal learning performance, in young and aged monkeys","volume":"34","author":"Burke","year":"2014","journal-title":"J Neurosci."},{"issue":"6","key":"2020050409375278400_ref11","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1037\/a0026238","article-title":"Age-associated deficits in pattern separation functions of the Perirhinal cortex: a cross-species consensus","volume":"125","author":"Burke","year":"2011","journal-title":"Behav Neurosci."},{"key":"2020050409375278400_ref12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbr.2018.02.008","article-title":"Different macaque models of cognitive aging exhibit task-dependent behavioral disparities","volume":"344","author":"Comrie","year":"2018","journal-title":"Behav Brain Res."},{"issue":"5","key":"2020050409375278400_ref13","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/gerona\/glw069","article-title":"Hearing impairment and incident dementia and cognitive decline in older adults: the health ABC study","volume":"72","author":"Deal","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"2","key":"2020050409375278400_ref14","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ijpsycho.2014.03.011","article-title":"Animal models of auditory temporal processing","volume":"95","author":"Eggermont","year":"2015","journal-title":"Int J Psychophysiol."},{"issue":"2","key":"2020050409375278400_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055092","article-title":"Age-related hearing loss in rhesus monkeys is correlated with Cochlear Histopathologies","volume":"8","author":"Engle","year":"2013","journal-title":"PLOS ONE."},{"issue":"11","key":"2020050409375278400_ref16","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/psyp.12288","article-title":"Taking the pulse of aging: mapping pulse pressure and elasticity in cerebral arteries with optical methods","volume":"51","author":"Fabiani","year":"2014","journal-title":"Psychophysiology."},{"issue":"3","key":"2020050409375278400_ref17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1037\/0894-4105.18.3.514","article-title":"Contribution of frontal and temporal lobe function to memory interference from divided attention at retrieval","volume":"18","author":"Fernandes","year":"2004","journal-title":"Neuropsychology."},{"issue":"1\u20132","key":"2020050409375278400_ref18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.heares.2010.01.006","article-title":"Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later","volume":"261","author":"Fowler","year":"2010","journal-title":"Hear Res."},{"issue":"4","key":"2020050409375278400_ref19","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1523\/JNEUROSCI.13-04-01479.1993","article-title":"Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic \u201cscotomas\u201d","volume":"13","author":"Funahashi","year":"1993","journal-title":"J Neurosci."},{"issue":"2","key":"2020050409375278400_ref20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1037\/0894-4105.9.2.229","article-title":"Double dissociation between item and source memory","volume":"9","author":"Glisky","year":"1995","journal-title":"Neuropsychology."},{"issue":"4","key":"2020050409375278400_ref21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1001\/archinternmed.2008.597","article-title":"Prevalence of age-related hearing loss in older adults: blue Mountains study","volume":"169","author":"Gopinath","year":"2009","journal-title":"Arch Intern Med."},{"key":"2020050409375278400_ref22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/B978-0-12-804042-3.00097-X","volume-title":"Evolution of Nervous Systems","author":"Gray","year":"2017","edition":"Second Edition"},{"issue":"Part B","key":"2020050409375278400_ref23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.bbr.2016.06.056","article-title":"Attentional updating and monitoring and affective shifting are impacted independently by aging in macaque monkeys","volume":"322","author":"Gray","year":"2017","journal-title":"Behav Brain Res."},{"issue":"2","key":"2020050409375278400_ref24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.17756\/jnpn.2018-023","article-title":"Tract-specific white matter correlates of age-related reward devaluation deficits in macaque monkeys","volume":"3","author":"Gray","year":"2018","journal-title":"J Neuroimaging Psychiatry Neurol"},{"issue":"1","key":"2020050409375278400_ref25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"NeuroImage."},{"issue":"5","key":"2020050409375278400_ref26","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s11357-011-9278-5","article-title":"Neuronal and morphological bases of cognitive decline in aged rhesus monkeys","volume":"34","author":"Hara","year":"2012","journal-title":"Age."},{"key":"2020050409375278400_ref27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF03393227","article-title":"A test apparatus for monkeys","volume":"2","author":"Harlow","year":"1938","journal-title":"Psychol Rec."},{"issue":"3","key":"2020050409375278400_ref28","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3758\/s13414-012-0406-9","article-title":"Are age-related changes in cognitive function driven by age-related changes in sensory processing?","volume":"75","author":"Humes","year":"2013","journal-title":"Atten Percept Psychophys."},{"key":"2020050409375278400_ref29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.maturitas.2018.02.002","article-title":"Association between speech and high-frequency hearing loss and depression, anxiety and stress in older adults","volume":"110","author":"Jayakody","year":"2018","journal-title":"Maturitas."},{"issue":"8","key":"2020050409375278400_ref30","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1097\/MAO.0000000000001502","article-title":"Impact of Cochlear implantation on cognitive functions of older adults: pilot test results","volume":"38","author":"Jayakody","year":"2017","journal-title":"Otol Neurotol."},{"issue":"44","key":"2020050409375278400_ref31","doi-asserted-by":"publisher","first-page":"14795","DOI":"10.1523\/JNEUROSCI.3393-10.2010","article-title":"Hierarchical and serial processing in the spatial auditory cortical pathway is degraded by natural aging","volume":"30","author":"Juarez-Salinas","year":"2010","journal-title":"J Neurosci."},{"issue":"2\u20133","key":"2020050409375278400_ref32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000013783","article-title":"Subdivisions of auditory cortex and levels of processing in primates","volume":"3","author":"Kaas","year":"1998","journal-title":"Audiol Neurootol."},{"issue":"22","key":"2020050409375278400_ref33","doi-asserted-by":"publisher","first-page":"11793","DOI":"10.1073\/pnas.97.22.11793","article-title":"Subdivisions of auditory cortex and processing streams in primates","volume":"97","author":"Kaas","year":"2000","journal-title":"Proc Natl Acad Sci."},{"issue":"2\u20133","key":"2020050409375278400_ref34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0531-5565(91)90010-J","article-title":"Age-related bone changes","volume":"26","author":"Kiebzak","year":"1991","journal-title":"Exp Gerontol."},{"issue":"28","key":"2020050409375278400_ref35","doi-asserted-by":"publisher","first-page":"10392","DOI":"10.1523\/JNEUROSCI.0595-11.2011","article-title":"Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness","volume":"31","author":"Lehman","year":"2011","journal-title":"J Neurosci."},{"issue":"10","key":"2020050409375278400_ref36","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1093\/gerona\/glr115","article-title":"Hearing loss and cognition among older adults in the United States","volume":"66A","author":"Lin","year":"2011","journal-title":"J Gerontol Ser A."},{"issue":"11","key":"2020050409375278400_ref37","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/nn.3536","article-title":"Subcortical origins of human and monkey neocortical interneurons","volume":"16","author":"Ma","year":"2013","journal-title":"Nat Neurosci."},{"issue":"9","key":"2020050409375278400_ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073021","article-title":"Diffusion weighted image denoising using overcomplete local PCA","volume":"8","author":"Manj\u00f3n","year":"2013","journal-title":"PLOS ONE."},{"key":"2020050409375278400_ref39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.heares.2017.01.016","article-title":"Auditory brainstem response latency in forward masking, a marker of sensory deficits in listeners with normal hearing thresholds","volume":"346","author":"Mehraei","year":"2017","journal-title":"Hear Res."},{"issue":"13","key":"2020050409375278400_ref40","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1523\/JNEUROSCI.4460-15.2016","article-title":"Auditory brainstem response latency in noise as a marker of cochlear synaptopathy","volume":"36","author":"Mehraei","year":"2016","journal-title":"J Neurosci."},{"issue":"3","key":"2020050409375278400_ref41","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1177\/0194599813518021","article-title":"The association between hearing loss and social isolation in older adults","volume":"150","author":"Mick","year":"2014","journal-title":"Otolaryngol Head Neck Surg."},{"issue":"10","key":"2020050409375278400_ref42","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.neurobiolaging.2005.08.004","article-title":"Executive system dysfunction occurs as early as middle-age in the rhesus monkey","volume":"27","author":"Moore","year":"2006","journal-title":"Neurobiol Aging."},{"issue":"7\u20138","key":"2020050409375278400_ref43","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/nbm.781","article-title":"Fiber tracking: principles and strategies - a technical review","volume":"15","author":"Mori","year":"2002","journal-title":"NMR Biomed."},{"issue":"4","key":"2020050409375278400_ref44","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrn3200","article-title":"The ageing cortical synapse: hallmarks and implications for cognitive decline","volume":"13","author":"Morrison","year":"2012","journal-title":"Nat Rev Neurosci."},{"issue":"Suppl 1","key":"2020050409375278400_ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s003930070031","article-title":"Age-related changes in bone mass, structure, and strength--effects of loading","volume":"59","author":"Mosekilde","year":"2000","journal-title":"Z Rheumatol."},{"issue":"5","key":"2020050409375278400_ref46","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.bbadis.2015.12.016","article-title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer\u2019s disease","volume":"1862","author":"Nelson","year":"2016","journal-title":"Biochim Biophys Acta."},{"issue":"1","key":"2020050409375278400_ref47","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1152\/jn.00663.2014","article-title":"Age-related changes of auditory brainstem responses in nonhuman primates","volume":"114","author":"Ng","year":"2015","journal-title":"J Neurophysiol."},{"key":"2020050409375278400_ref48","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00113","article-title":"Age-related hearing impairment and frailty in Alzheimer\u2019s disease: interconnected associations and mechanisms","volume":"7","author":"Panza","year":"2015","journal-title":"Front Aging Neurosci."},{"issue":"35","key":"2020050409375278400_ref49","doi-asserted-by":"publisher","first-page":"12638","DOI":"10.1523\/JNEUROSCI.2559-11.2011","article-title":"Hearing loss in older adults affects neural systems supporting speech comprehension","volume":"31","author":"Peelle","year":"2011","journal-title":"J Neurosci."},{"issue":"4","key":"2020050409375278400_ref50","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/cercor\/bhp142","article-title":"Neural processing during older adults\u2019 comprehension of spoken sentences: age differences in resource allocation and connectivity","volume":"20","author":"Peelle","year":"2010","journal-title":"Cereb Cortex"},{"key":"2020050409375278400_ref51","first-page":"1597","volume-title":"ISMRM 18th annual meeting","author":"Pierpaoli","year":"2010"},{"key":"2020050409375278400_ref52","volume-title":"Gaussian processes for machine learning","author":"Rasmussen","year":"2006"},{"key":"2020050409375278400_ref53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.59.103006.093544","article-title":"The biological basis of audition","volume":"59","author":"Recanzone","year":"2008","journal-title":"Annu Rev Psychol."},{"issue":"12","key":"2020050409375278400_ref54","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/16056","article-title":"Dual streams of auditory afferents target multiple domains in the primate prefrontal cortex","volume":"2","author":"Romanski","year":"1999","journal-title":"Nat Neurosci."},{"issue":"8","key":"2020050409375278400_ref55","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/nn.3440","article-title":"Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating","volume":"16","author":"Rudebeck","year":"2013","journal-title":"Nat Neurosci."},{"issue":"1","key":"2020050409375278400_ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(78)90584-X","article-title":"Afferent cortical connections and architectonics of the superior temporal sulcus and surrounding cortex in the rhesus monkey","volume":"149","author":"Seltzer","year":"1978","journal-title":"Brain Res."},{"issue":"2","key":"2020050409375278400_ref57","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1523\/JNEUROSCI.2908-03.2004","article-title":"Dynamic analysis of learning in Behavioral experiments","volume":"24","author":"Smith","year":"2004","journal-title":"J Neurosci."},{"issue":"4","key":"2020050409375278400_ref58","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.903500402","article-title":"Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents","volume":"350","author":"Suzuki","year":"1994","journal-title":"J Comp Neurol."},{"issue":"10","key":"2020050409375278400_ref59","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat Neurosci."},{"key":"2020050409375278400_ref60","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.160","article-title":"Memory impairment in aged primates is associated with region-specific network dysfunction","author":"Thom\u00e9","year":"2015","journal-title":"Mol Psychiatry."},{"issue":"3","key":"2020050409375278400_ref61","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/jmri.22837","article-title":"In vivo assessment of neurodegeneration in Niemann-pick type C mice by quantitative T2 mapping and diffusion tensor imaging","volume":"35","author":"Totenhagen","year":"2012","journal-title":"J Magn Reson Imaging JMRI."},{"key":"2020050409375278400_ref62","article-title":"N4ITK: Nick\u2019s N3 ITK implementation for MRI bias field correction","author":"Tustison","year":"2009","journal-title":"Insight J."},{"issue":"6","key":"2020050409375278400_ref63","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans Med Imaging."},{"issue":"7359","key":"2020050409375278400_ref64","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nature10243","article-title":"Neuronal basis of age-related working memory decline","volume":"476","author":"Wang","year":"2011","journal-title":"Nature."},{"issue":"1","key":"2020050409375278400_ref65","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/jamaoto.2016.2661","article-title":"Increases in the rate of age-related hearing loss in the older old","volume":"143","author":"Wattamwar","year":"2017","journal-title":"JAMA Otolaryngol Neck Surg."},{"issue":"21","key":"2020050409375278400_ref66","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1523\/JNEUROSCI.0952-08.2008","article-title":"Prefrontal\u2013inferotemporal interaction is not always necessary for reversal learning","volume":"28","author":"Wilson","year":"2008","journal-title":"J Neurosci."},{"issue":"21","key":"2020050409375278400_ref67","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.1073\/pnas.1101567108","article-title":"Age-related memory deficits linked to circuit-specific disruptions in the hippocampus","volume":"108","author":"Yassa","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"10","key":"2020050409375278400_ref68","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."},{"issue":"12","key":"2020050409375278400_ref69","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1523\/JNEUROSCI.09-12-04355.1989","article-title":"Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment","volume":"9","author":"Zola-Morgan","year":"1989","journal-title":"J Neurosci."}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/5\/2789\/33161136\/bhz275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/5\/2789\/33161136\/bhz275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T09:38:30Z","timestamp":1588585110000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/30\/5\/2789\/5675111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,7]]},"references-count":69,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,3,7]]},"published-print":{"date-parts":[[2020,5,14]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhz275","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737079383.793572263","asserted-by":"object"}]},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,5]]},"published":{"date-parts":[[2020,3,7]]}}}