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We aimed to identify the regions throughout neocortex where clinical psychosis manifestations correlate with cortical thickness. Rather than perform a traditional correlation analysis using total scores on psychiatric rating scales, we applied multidimensional item response theory to identify a profile of psychotic symptoms that was related to a region where cortical thickness was reduced. This analysis was performed using a large population of probands with psychotic disorders (N\u00a0=\u2009865), their family members (N\u00a0=\u2009678) and healthy volunteers (N\u00a0=\u2009347), from the 5-site Bipolar-Schizophrenia Network for Intermediate Phenotypes. Regional cortical thickness from structural magnetic resonance scans was measured using FreeSurfer; individual symptoms were rated using the Positive and Negative Syndrome Scale, Montgomery-Asberg Depression Rating Scale, and Young Mania Rating Scale. A cluster of cortical regions whose thickness was inversely related to severity of psychosis symptoms was identified. The regions turned out to be located contiguously in a large region of heteromodal association cortex including temporal, parietal and frontal lobe regions, suggesting a cluster of contiguous neocortical regions important to psychosis expression. When we tested the relationship between reduced cortical surface area and high psychotic symptoms we found no linked regions describing a related cortical set.<\/jats:p>","DOI":"10.1093\/cercor\/bhz285","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T12:11:04Z","timestamp":1574770264000},"page":"2939-2947","source":"Crossref","is-referenced-by-count":11,"title":["Associating Psychotic Symptoms with Altered Brain Anatomy in Psychotic Disorders Using Multidimensional Item Response Theory Models"],"prefix":"10.1093","volume":"30","author":[{"given":"Ana D","family":"Stan","sequence":"first","affiliation":[{"name":"Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A","family":"Tamminga","sequence":"first","affiliation":[{"name":"Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, 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