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Despite these crucial roles, our understanding of the molecular and cellular processes giving rise to the CPs within the ventricles of the mammalian brain is very rudimentary. Here, we identify WNT5a as an important regulator of CP development, where it acts as a pivotal factor driving CP epithelial morphogenesis in all ventricles. We show that WNT5a is essential for the establishment of a cohesive epithelium in the developing CP. We find that in its absence all CPs are substantially reduced in size and complexity and fail to expand into the ventricles. Severe defects were observed in the epithelial cytoarchitecture of all Wnt5a\u2212\/\u2212 CPs, exemplified by loss of apicobasally polarized morphology and detachment from the ventricular surface and\/or basement membrane. We also present evidence that the WNT5a receptor, RYK, and the RHOA kinase, ROCK, are required for normal CP epithelial morphogenesis. Our study, therefore, reveals important insights into the molecular and cellular mechanisms governing CP development.<\/jats:p>","DOI":"10.1093\/cercor\/bhz330","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:11:25Z","timestamp":1576239085000},"page":"3617-3631","source":"Crossref","is-referenced-by-count":24,"title":["WNT5a Regulates Epithelial Morphogenesis in the Developing Choroid Plexus"],"prefix":"10.1093","volume":"30","author":[{"given":"Michael B","family":"Langford","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor J","family":"O\u2019Leary","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenin","family":"Veeraval","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"White","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Lanoue","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M","family":"Cooper","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane 4072, Australia and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"2020051808281223700_ref1","doi-asserted-by":"crossref","first-page":"44518","DOI":"10.1074\/jbc.M112.414441","article-title":"The Wnt coreceptor Ryk regulates Wnt\/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2","volume":"287","author":"Andre","year":"2012","journal-title":"J Biol Chem."},{"key":"2020051808281223700_ref2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng1228","article-title":"Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation","volume":"35","author":"Awatramani","year":"2003","journal-title":"Nat Genet."},{"key":"2020051808281223700_ref3","doi-asserted-by":"crossref","first-page":"F549","DOI":"10.1152\/ajprenal.00566.2009","article-title":"Planar cell polarity pathway regulates actin rearrangement, cell shape, 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