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However, the proportion of forebrain-induced excitatory and inhibitory effects often differs when taste cell recording changes from the NST to the PBN. The present study investigated whether this descending influence might originate from a shared or distinct population of neurons marked by expression of somatostatin (Sst). In Sst-reporter mice, the retrograde tracers\u2019 cholera toxin subunit B AlexaFluor-488 and -647 conjugates were injected into the taste-responsive regions of the NST and the ipsilateral PBN. In Sst-cre mice, the cre-dependent retrograde tracers\u2019 enhanced yellow fluorescent protein Herpes Simplex Virus (HSV) and mCherry fluorescent protein HSV were injected into the NST and the ipsilateral PBN. The results showed that ~40% of CeA-to-PBN neurons expressed Sst compared with ~ 23% of CeA-to-NST neurons. For both the CeA Sst-positive and -negative populations, the vast majority projected to the NST or PBN but not both nuclei. Thus, a subset of CeA-to-NST and CeA-to-PBN neurons are marked by Sst expression and are largely distinct from one another. Separate populations of CeA\/Sst neurons projecting to the NST and PBN suggest that differential modulation of taste processing might, in part, rely on differences in local brainstem\/forebrain synaptic connections.<\/jats:p>","DOI":"10.1093\/chemse\/bjaa059","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:22:47Z","timestamp":1600284167000},"page":"687-698","source":"Crossref","is-referenced-by-count":18,"title":["Distinct Populations of Amygdala Somatostatin-Expressing Neurons Project to the Nucleus of the Solitary Tract and Parabrachial Nucleus"],"prefix":"10.1093","volume":"45","author":[{"given":"Jane J","family":"Bartonjo","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F","family":"Lundy","sequence":"additional","affiliation":[{"name":"Department of 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