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This involuntary reflex can be evoked when hazardous substances activate mucosal receptors, which send signals to be processed within the brainstem. Although the LCR is meant to be protective, the reflex can become hyperstimulated, even to benign stimuli, which can result in pathological disorders, such as chronic cough and inducible laryngeal obstruction. In this review, we will outline the mechanism of the LCR and its associated pathological disorders.<\/jats:p>","DOI":"10.1093\/chemse\/bjaa069","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T11:16:19Z","timestamp":1602242179000},"page":"823-831","source":"Crossref","is-referenced-by-count":17,"title":["Laryngeal Chemoreflex in Health and Disease: A Review"],"prefix":"10.1093","volume":"45","author":[{"given":"Shivani","family":"Pathak","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Slovarp","sequence":"additional","affiliation":[{"name":"School of Speech, Language, Hearing, & Occupational Sciences, University of Montana, Missoula, MT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Clary","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E","family":"Jett\u00e9","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"issue":"9974","key":"2020120504570124200_CIT0001","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(14)61255-1","article-title":"P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study","volume":"385","author":"Abdulqawi","year":"2015","journal-title":"Lancet"},{"issue":"6","key":"2020120504570124200_CIT0002","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1067\/mhn.2002.127589","article-title":"Cough and paradoxical vocal fold motion","volume":"127","author":"Altman","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"2020120504570124200_CIT0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0194599816640249","article-title":"Laryngopharyngeal reflux has negative effects on taste and smell functions","volume":"155","author":"Altundag","year":"2016","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"2020120504570124200_CIT0004","first-page":"2574","article-title":"Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents","volume":"118","author":"Andr\u00e8","year":"2008","journal-title":"J Clin Invest"},{"issue":"6","key":"2020120504570124200_CIT0005","doi-asserted-by":"crossref","first-page":"e925","DOI":"10.4317\/medoral.17706","article-title":"Obstructive sleep apnea syndrome (OSAS). 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