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Distortions of taste perception, including blunted recognition thresholds, intensity, and hedonic ratings have been identified in those suffering from depressive disorders. Serotonin is a key neurotransmitter implicated in the etiology of anxiety and depression; systemic and peripheral manipulations of serotonin signaling have previously been shown to modulate taste detection. However, the specific effects of central serotonin function on taste processing have not been widely investigated. Here, in a double-blind placebo-controlled study, acute tryptophan depletion was used to investigate the effect of reduced central serotonin function on taste perception. Twenty-five female participants aged 18\u201328 attended the laboratory on two occasions at least 1 week apart. On one visit, they received a tryptophan depleting drink and on the other, a control drink was administered. Approximately, 6 h after drink consumption, they completed a taste perception task which measured detection thresholds and supra-threshold perceptions of the intensity and pleasantness of four basic tastes (sweet, sour, bitter, and salt). While acutely reducing central levels of serotonin had no effect on the detection thresholds of sweet, bitter, or sour tastes, it significantly enhanced detection of salt. For supra-threshold stimuli, acutely reduced serotonin levels significantly enhanced the perceived intensity of both bitter and sour tastes and blunted pleasantness ratings of bitter quinine. These findings show manipulation of central serotonin levels can modulate taste perception and are consistent with previous reports that depletion of central serotonin levels enhances neural and behavioral responsiveness to aversive signals.<\/jats:p>","DOI":"10.1093\/chemse\/bjaa078","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T21:09:55Z","timestamp":1606943395000},"source":"Crossref","is-referenced-by-count":8,"title":["Effects of Acute Tryptophan Depletion on Human Taste Perception"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9162-625X","authenticated-orcid":false,"given":"Sharon A","family":"Smith","sequence":"first","affiliation":[{"name":"Research Centre for Brain and Behaviour, School of Psychology, Liverpool John Moores University, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula D","family":"Trotter","sequence":"additional","affiliation":[{"name":"Research Centre for Brain and Behaviour, School of Psychology, Liverpool John Moores University, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis P","family":"McGlone","sequence":"additional","affiliation":[{"name":"Research Centre for Brain and Behaviour, School of Psychology, Liverpool John Moores University, Liverpool, UK"},{"name":"Department of Psychology, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-3544","authenticated-orcid":false,"given":"Susannah C","family":"Walker","sequence":"additional","affiliation":[{"name":"Research Centre for Brain and Behaviour, School of Psychology, Liverpool John Moores University, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"issue":"1","key":"2021021816582703800_CIT0001","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0954579411000824","article-title":"The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood","volume":"24","author":"Adkins","year":"2012","journal-title":"Dev Psychopathol"},{"issue":"1","key":"2021021816582703800_CIT0002","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1469-8986.2011.01289.x","article-title":"Exposure to acute stress is associated with attenuated sweet taste","volume":"49","author":"Al\u2019Absi","year":"2012","journal-title":"Psychophysiology"},{"issue":"12","key":"2021021816582703800_CIT0003","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/0006-3223(87)90108-9","article-title":"Taste and smell perception in depression","volume":"22","author":"Amsterdam","year":"1987","journal-title":"Biol Psychiatry"},{"issue":"1\u20132","key":"2021021816582703800_CIT0004","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.psychres.2014.07.045","article-title":"Sweet taste sensitivity is influenced by 5-HTTLPR genotype and affected in seasonal affective disorder","volume":"220","author":"Andersen","year":"2014","journal-title":"Psychiatry Res"},{"issue":"3","key":"2021021816582703800_CIT0005","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0165-1781(95)02816-1","article-title":"Seasonal alteration in taste detection and recognition threshold in seasonal affective disorder: the proximate source of carbohydrate craving","volume":"59","author":"Arbisi","year":"1996","journal-title":"Psychiatry Res"},{"issue":"4","key":"2021021816582703800_CIT0007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1037\/1089-2680.5.4.323","article-title":"Bad is stronger than good","volume":"5","author":"Baumeister","year":"2001","journal-title":"Rev Gen Psychol"},{"key":"2021021816582703800_CIT0008","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"2021021816582703800_CIT0009","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/j.1440-1614.2005.01628.x","article-title":"Acute tryptophan depletion. 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