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SHRs also ingested more sucrose than normotensive rats, without differences in quinine hydrochloride intake. Here, we investigated the palatability of SHRs (n = 8\u201310) and normotensive Holtzman rats (n = 8\u201310) to sucrose and quinine sulphate infused intraorally in the same conditions that NaCl palatability was increased in SHRs. SHRs had similar number of hedonic responses to 2% sucrose in euhydrated condition (95 \u00b1 19) or after WD-PR (142 \u00b1 25), responses increased when compared with normotensive rats in euhydrated condition (13 \u00b1 3) or after WD-PR (21 \u00b1 6). SHRs also showed increased number of aversive responses to 1.4 mM quinine sulphate compared with normotensive rats, whether in euhydrated condition (86 \u00b1 6, vs. normotensive: 54 \u00b1 7) or after WD-PR (89 \u00b1 9, vs. normotensive: 40 \u00b1 9). The results suggest that similar to NaCl taste, sweet taste responses are increased in SHRs and resistant to challenges in bodily fluid balance. They also showed a more intense aversive response in SHRs to bitter taste compared with normotensives. This suggests that the enhanced response of SHRs to taste rewards does not correspond to a decreased response to a typical aversive taste.<\/jats:p>","DOI":"10.1093\/chemse\/bjad013","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T08:59:58Z","timestamp":1682153998000},"source":"Crossref","is-referenced-by-count":2,"title":["Palatability profile in spontaneously hypertensive rats"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-5904","authenticated-orcid":false,"suffix":"Jr","given":"Emilson Donizete","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathology, Dentistry School, S\u00e3o Paulo State University\u2014UNESP , Araraquara, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-2652","authenticated-orcid":false,"suffix":"Jr","given":"Laurival A","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, Dentistry School, S\u00e3o Paulo State University\u2014UNESP , Araraquara, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-4441","authenticated-orcid":false,"given":"Jos\u00e9 Vanderlei","family":"Menani","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, Dentistry School, S\u00e3o Paulo State University\u2014UNESP , Araraquara, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-2202","authenticated-orcid":false,"given":"Carina Aparecida Fabr\u00edcio","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, Dentistry School, S\u00e3o Paulo State University\u2014UNESP , Araraquara, SP 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