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In the present study, it was investigated which of these mechanisms causes the suppression of sweetness by citric acid. This was investigated using a split-tongue gustometer that can stimulate the two sides of the tongue with different stimuli simultaneously, enabling a comparison of sucrose and citric acid presented either separately on each side of the tongue simultaneously or in a mixture on one side. Two studies were conducted using low (Study 1; n = 50) and high (Study 2: n = 59) concentrations of sucrose (2.5% (w\/w) and 10% (w\/w), respectively), and citric acid (0.14% (w\/w) and 0.18% (w\/w), respectively). In neither of the studies was there a significant difference in sweetness intensity ratings between the two conditions where sucrose and citric acid were presented either separately or in a mixture form. However, both showed significantly lower sweetness ratings than without citric acid indicating suppression of the sweetness of sucrose from citric acid. This provides strong evidence for a central mechanism for the suppression of the sweetness of sucrose by citric acid. This mechanism seems to be equal in high and low concentrations of both sucrose and citric acid.<\/jats:p>","DOI":"10.1093\/chemse\/bjad036","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T13:51:48Z","timestamp":1693921908000},"source":"Crossref","is-referenced-by-count":9,"title":["Suppression of sweetness: evidence for central mechanism for suppression of sweetness from sucrose by citric acid"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-6894","authenticated-orcid":false,"given":"Jonas Yde","family":"Junge","sequence":"first","affiliation":[{"name":"Food Quality Perception & Society, iSense Lab, Department of Food Science, Aarhus University , Aarhus , Denmark"},{"name":"Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences , Aarhus\/Beijing , Denmark\/China"},{"name":"Monell Chemical Senses Center , Philadelphia, PA , United 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