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However, so far taste and smell organs appeared morphologically to be very distinct, with a specialized olfactory epithelium for detection of odors and taste buds located in the oral cavity and lip for detection of tastants. Here, we report dense clusters of cells expressing T1R and T2R receptors as well as their signal transduction molecule PLC\u03b22 in nostrils of zebrafish, i.e. on the entrance funnel through which odor molecules must pass to be detected by olfactory sensory neurons. Quantitative evaluation shows the density of these chemosensory cells in the nostrils to be as high or higher than that in the established taste organs oral cavity and lower lip. Hydrodynamic flow is maximal at the nostril rim enabling high throughput chemosensation in this organ. Taken together, our results suggest a sentinel function for these chemosensory cells in the nostril.<\/jats:p>","DOI":"10.1093\/chemse\/bjad040","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:45:27Z","timestamp":1697478327000},"source":"Crossref","is-referenced-by-count":4,"title":["Expression of taste sentinels, T1R, T2R, and PLC\u03b22, on the passageway for olfactory signals in zebrafish"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-2934","authenticated-orcid":false,"given":"G\u00fcnes","family":"Birdal","sequence":"first","affiliation":[{"name":"Institute for Genetics, Department of Biology, University of Cologne , Z\u00fclpicher Str. 47A, 50674 Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Percival P","family":"D\u2019Gama","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , Erling Skjalgsons Gate 1, 7491 Trondheim , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Jurisch-Yaksi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology , Erling Skjalgsons Gate 1, 7491 Trondheim , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-172X","authenticated-orcid":false,"given":"Sigrun I","family":"Korsching","sequence":"additional","affiliation":[{"name":"Institute for Genetics, Department of Biology, University of Cologne , Z\u00fclpicher Str. 47A, 50674 Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"2023110711513289700_CIT0001","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1601-183X.2008.00433.x","article-title":"Construction of a 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