{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:13:20Z","timestamp":1784852000213,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Volkswagen Stiftung","award":["Az 9B396"],"award-info":[{"award-number":["Az 9B396"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The sense of smell is based on sensory detection of the molecule(s), which is then further perceptually interpreted. A possible measure of olfactory perception is an odor-independent olfactory perceptual fingerprint (OPF) defined by Snitz et al. We aimed to investigate whether OPF can distinguish patients with olfactory dysfunction (OD) due to coronavirus disease (COVID-19) from controls and which perceptual descriptors are important for that separation. Our study included 99 healthy controls and 41 patients. They rated 10 odors using 8 descriptors such as \u201cpleasant,\u201d \u201cintense,\u201d \u201cfamiliar,\u201d \u201cwarm,\u201d \u201ccold,\u201d \u201cirritating,\u201d \u201cedible,\u201d and \u201cdisgusting.\u201d An unsupervised machine learning method, hierarchical cluster analysis, showed that OPF can distinguish patients from controls with an accuracy of 83%, a sensitivity of 51%, and a specificity of 96%. Furthermore, a supervised machine learning method, random forest classifier, showed that OPF can distinguish patients and controls in the testing dataset with an accuracy of 86%, a sensitivity of 64%, and a specificity of 96%. Principal component analysis and random forest classifier showed that familiarity and intensity were the key qualities to explain the variance of the data. In conclusion, people with COVID-19-related OD have a fundamentally different olfactory perception.<\/jats:p>","DOI":"10.1093\/chemse\/bjad050","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:51:45Z","timestamp":1702623105000},"source":"Crossref","is-referenced-by-count":6,"title":["An olfactory perceptual fingerprint in people with olfactory dysfunction due to COVID-19"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-2334","authenticated-orcid":false,"given":"Eva","family":"Drnovsek","sequence":"first","affiliation":[{"name":"Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universit\u00e4t Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rommel","sequence":"additional","affiliation":[{"name":"Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universit\u00e4t Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1106","authenticated-orcid":false,"given":"Antonie Louise","family":"Bierling","sequence":"additional","affiliation":[{"name":"Institute for Materials Science, Technische Universit\u00e4t Dresden , 01062 Dresden , Germany"},{"name":"Department of Psychotherapy and Psychosomatics, Technische Universit\u00e4t Dresden , 01062 Dresden , Germany"},{"name":"Department of Clinical Psychology, Friedrich-Schiller-University of Jena , 07743 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9296-9350","authenticated-orcid":false,"given":"Alexander","family":"Croy","sequence":"additional","affiliation":[{"name":"Institute of Physical Chemistry, Friedrich-Schiller-University of Jena , 07743 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-5559","authenticated-orcid":false,"given":"Ilona","family":"Croy","sequence":"additional","affiliation":[{"name":"Department of Psychotherapy and Psychosomatics, Technische Universit\u00e4t Dresden , 01062 Dresden , Germany"},{"name":"Department of Clinical Psychology, Friedrich-Schiller-University of Jena , 07743 Jena , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-0183","authenticated-orcid":false,"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universit\u00e4t Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"issue":"2","key":"2024010317193665900_CIT0001","first-page":"160","article-title":"Olfactory detection thresholds and pleasantness of a food-related and a non-food odour in hunger and satiety","volume":"47","author":"Albrecht","year":"2009","journal-title":"Rhinology"},{"issue":"9","key":"2024010317193665900_CIT0002","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.cub.2022.02.062","article-title":"The perception of odor pleasantness is shared across cultures","volume":"32","author":"Arshamian","year":"2022","journal-title":"Curr Biol"},{"issue":"2-3","key":"2024010317193665900_CIT0003","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.psychres.2008.11.016","article-title":"Olfactory anhedonia and negative olfactory alliesthesia in depressed patients","volume":"176","author":"Atanasova","year":"2010","journal-title":"Psychiatry Res"},{"issue":"1","key":"2024010317193665900_CIT0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/chemse\/23.1.31","article-title":"Differences in perception of everyday odors: a Japanese-German cross-cultural study","volume":"23","author":"Ayabe-Kanamura","year":"1998","journal-title":"Chem Senses"},{"issue":"5","key":"2024010317193665900_CIT0005","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/brainsci11050563","article-title":"Olfactory perception in relation to the physicochemical odor space","volume":"11","author":"Bierling","year":"2021","journal-title":"Brain Sci"},{"key":"2024010317193665900_CIT0006","article-title":"Development of a chemical\u2013perceptual space of olfaction (CROWN). 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