{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:24Z","timestamp":1790837064872,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":262,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["2016:0229"],"award-info":[{"award-number":["2016:0229"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-00266"],"award-info":[{"award-number":["2020-00266"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Self-reported measures emerge as potential indicators for early detection of dementia and mortality. We investigated the predictive value of different self-reported measures, including subjective cognitive decline (SCD), subjective olfactory impairment (SOI), subjective taste impairment (STI), and self-reported poor health (SPH), in order to determine the risk of progressing to Alzheimer\u2019s disease (AD) dementia, Parkinson\u2019s disease (PD) dementia, or any-other-cause dementia. A total of 6,028 cognitively unimpaired individuals from the 8th wave of the English Longitudinal Study of Ageing (ELSA) were included as the baseline sample and 5,297 individuals from the 9th wave were included as 2-year follow-up sample. Self-rated measures were assessed using questions from the ELSA structured interview. Three logistic regression models were fitted to predict different the dementia outcomes. SCD based on memory complaints (OR\u2005=\u200511.145; P\u2005&amp;lt;\u20050.001), and older age (OR\u2005=\u20051.108, P\u2005&amp;lt;\u20050.001) significantly predicted the progression to AD dementia at follow-up. SOI (OR\u2005=\u20057.440; P\u2005&amp;lt;\u20050.001) and older age (OR\u2005=\u20051.065, P\u2005=\u20050.035) significantly predicted the progression to PD dementia at follow-up. Furthermore, SCD based on memory complaints (OR\u2005=\u20054.448; P\u2005&amp;lt;\u20050.001) jointly with complaints in other (non-memory) mental abilities (OR\u2005=\u20056.662; P\u2005&amp;lt;\u20050.001), and older age (OR\u2005=\u20051.147, P\u2005&amp;lt;\u20050.001) significantly predicted the progression to dementia of any other cause. Different types of complaints are specifically associated with different dementia outcomes. Our study demonstrates that self-reported measures are a useful and accessible tool when screening for individuals at risk of dementia in the general population.<\/jats:p>","DOI":"10.1093\/chemse\/bjae033","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T19:20:27Z","timestamp":1726687227000},"source":"Crossref","is-referenced-by-count":5,"title":["Subjective cognitive and olfactory impairments predict different prospective dementia outcomes"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-6451","authenticated-orcid":false,"given":"Nira","family":"Cedres","sequence":"first","affiliation":[{"name":"Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-Lab), Stockholm University , Stockholm ,","place":["Sweden"]},{"name":"Department of Psychology, Faculty of Health Sciences, University Fernando Pessoa Canarias , Las Palmas de Gran Canaria ,","place":["Spain"]},{"name":"Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-0569","authenticated-orcid":false,"given":"Jonas K","family":"Olofsson","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-Lab), Stockholm University , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"11","key":"2024100303024925000_CIT0001","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/gerona\/glad168","article-title":"Polygenic propensity for longevity, APOE-\u03b54 status, dementia diagnosis, and risk for cause-specific mortality: a large population-based longitudinal study of older adults","volume":"78","author":"Ajnakina","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"2024100303024925000_CIT0002","first-page":"265","article-title":"Olfactory tau pathology in Alzheimer disease and mild cognitive impairment","volume":"25","author":"Attems","year":"2006","journal-title":"Clin Neuropathol"},{"issue":"15","key":"2024100303024925000_CIT0003","article-title":"Self-rated health and public health: a critical perspective","volume":"1","author":"Bombak","year":"2013","journal-title":"Front Public Heal"},{"issue":"12","key":"2024100303024925000_CIT0004","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jamaneurol.2017.2216","article-title":"Region-specific association of subjective cognitive decline with tauopathy independent of global \u03b2-amyloid burden","volume":"74","author":"Buckley","year":"2017","journal-title":"JAMA Neurol"},{"issue":"1","key":"2024100303024925000_CIT0005","first-page":"670","article-title":"Using subjective cognitive decline to identify high global amyloid in community-based samples: a cross-cohort study","volume":"11","author":"Buckley","year":"2019","journal-title":"Alzheimer\u2019s & Dementia (Amsterdam, Netherlands)"},{"issue":"1","key":"2024100303024925000_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/geronb\/gbac124","article-title":"Subjective impairments in olfaction and cognition predict dissociated behavioral outcomes","volume":"78","author":"Cedres","year":"2023","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"issue":"16","key":"2024100303024925000_CIT0007","doi-asserted-by":"crossref","first-page":"19963","DOI":"10.18632\/aging.203467","article-title":"The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline","volume":"13","author":"Cedres","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"2024100303024925000_CIT0008","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/JAD-180720","article-title":"Subjective cognitive decline below and above the age of 60: a multivariate study on neuroimaging, cognitive, clinical, and demographic measures","volume":"68","author":"Cedres","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2024100303024925000_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12955-020-01440-x","article-title":"Measuring the well-being of people with dementia: a conceptual scoping review","volume":"18","author":"Clarke","year":"2020","journal-title":"Health Qual Life Outcomes"},{"issue":"9","key":"2024100303024925000_CIT0010","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1093\/brain\/awad094","article-title":"Lecanemab: turning point, or status quo? 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