{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:26Z","timestamp":1753876046101,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Studies on taste bud cells and brain stem relay nuclei suggest that alternative pathways convey information regarding different taste qualities. Building on the hypothesis that amiloride (epithelial Na channel antagonist)-sensitive neurons respond to palatable salt (low-concentration) and amiloride-insensitive neurons respond to aversive salt (high-concentration), we investigated the histological distribution of taste-sensitive neurons in the rostral nucleus of the solitary tract in rats and their NaCl and amiloride sensitivities. We recorded neuronal activity in extracellular single units using multi-barrel glass micropipettes and reconstructed their locations on the rostrocaudal and mediolateral axes. Seventy-three taste-sensitive neurons were categorized into the best-taste category. The amiloride sensitivities of the 31 neurons were examined for 0.1, 0.2, 0.4, and 0.8 M NaCl. The neuronal distribution of amiloride-sensitive neurons was located in the lateral region, while amiloride-insensitive neurons were located in the medial region. The amiloride-sensitive neurons responded to low salt concentrations, signaling the NaCl levels required by body fluids. Amiloride-insensitive neurons were silent at low salt concentrations but may function as warning signals for high salt concentrations. Low-threshold and\/or high-response neurons were located in the rostrolateral region. In contrast, high-threshold and\/or low-response neurons were located in the caudal-medial region.<\/jats:p>","DOI":"10.1093\/chemse\/bjae036","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T09:54:58Z","timestamp":1727776498000},"source":"Crossref","is-referenced-by-count":1,"title":["Different taste map for amiloride sensitivity, response frequency, and threshold to NaCl in the rostral nucleus of the solitary tract in rats"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-0500","authenticated-orcid":false,"given":"Tatsuko","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Dentistry, Aichi-Gakuin University , Nagoya 464-8650,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunari","family":"Hiraba","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Dentistry, Aichi-Gakuin University , Nagoya 464-8650,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,1]]},"container-title":["Chemical Senses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/chemse\/advance-article-pdf\/doi\/10.1093\/chemse\/bjae036\/59469678\/bjae036.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/chemse\/advance-article-pdf\/doi\/10.1093\/chemse\/bjae036\/59469678\/bjae036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T09:54:59Z","timestamp":1727776499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/chemse\/advance-article\/doi\/10.1093\/chemse\/bjae036\/7798471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/chemse\/bjae036","relation":{},"ISSN":["0379-864X","1464-3553"],"issn-type":[{"type":"print","value":"0379-864X"},{"type":"electronic","value":"1464-3553"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"article-number":"bjae036"}}