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However, the lateralization of olfactory processes is known to depend on the task and nature of stimuli. It still remains unclear whether olfactory system projections in humans also correspond to functional pathways during olfactory tasks without any trigeminal, perceptual, or cognitive-motor components. Twenty young healthy subjects with a normal sense of smell took part in an olfactory functional magnetic resonance imaging (fMRI) study. We used 2 types of nostril-specific stimulation, passive (no sniffing), and active (with sniffing), with phenyl ethyl alcohol, a pure olfactory stimulant, to investigate fMRI activity patterns in primary and secondary olfactory-related brain structures. Irrespective of the stimulated nostril and the type of stimulation, we detected symmetrical activity in primary and secondary olfactory-related brain structures such as the primary olfactory cortex, entorhinal cortex, and orbitofrontal cortex. In the absence of perceptual or cognitive-motor task demands, the perception of monorhinally presented pure odors is processed bilaterally in the brain.<\/jats:p>","DOI":"10.1093\/chemse\/bjae038","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T15:21:39Z","timestamp":1728400899000},"source":"Crossref","is-referenced-by-count":3,"title":["Monorhinal and birhinal odor processing in humans: an fMRI investigation"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2843-5882","authenticated-orcid":false,"given":"Anupa","family":"Ekanayake","sequence":"first","affiliation":[{"name":"Grodno State Medical University , Grodno,","place":["Belarus"]},{"name":"Department of Radiology, Penn State University College of Medicine , Hershey, PA ,","place":["United 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