{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:35:32Z","timestamp":1761215732207,"version":"build-2065373602"},"reference-count":220,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":266,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eating behavior is shaped by genetic, psychological, and physiological factors, with nutrient sensing playing a central role in modulating intake. The tongue, as the primary gustatory organ, initiates this process by influencing hedonic preferences, food choices, and feeding behavior. Recent sensory research has highlighted the potential role of an emerging class of taste modalities known as alimentary tastes. This concept refers to the gustatory detection of compounds that produce weak or subtle taste perceptions but elicit strong postoral effects. While most studies have focused on umami and fat taste in that category, growing interest surrounds newly characterized modalities such as kokumi- and complex carbohydrate-associated tastes. Basic and alimentary taste stimulus influence behavior and physiological processes both pre- and postingestion. Their receptors, present in enteroendocrine cells, detect specific nutrients and regulate gut feedback mechanisms. Emerging research is investigating not only their involvement in metabolic disorders and conditions such as malnutrition, but also their potential as therapeutic targets for modulating appetite, nutrient absorption, and endocrine responses. This narrative review aims to identify and characterize the functions of these postoral receptors along the gastrointestinal tract in the regulation of food intake and to evaluate their therapeutic potential in metabolic conditions such as obesity and type 2 diabetes.<\/jats:p>","DOI":"10.1093\/chemse\/bjaf039","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:15:11Z","timestamp":1758701711000},"source":"Crossref","is-referenced-by-count":0,"title":["Postoral receptors and alimentary taste: implications for energy intake and appetite"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8464-2183","authenticated-orcid":false,"given":"Camille","family":"Pennaneach","sequence":"first","affiliation":[{"name":"CASS Food Research Centre, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University , Burwood, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-1222","authenticated-orcid":false,"given":"Andrew","family":"Costanzo","sequence":"additional","affiliation":[{"name":"CASS Food Research Centre, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University , Burwood, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-6057","authenticated-orcid":false,"given":"Caterina","family":"Dinnella","sequence":"additional","affiliation":[{"name":"Food Science and Technology, Department of Agricultural, Food, Environmental and Forestry Sciences and Technologies, University of Florence , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-6276","authenticated-orcid":false,"given":"Sara","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Food Science and Technology, Department of Agricultural, Food, Environmental and Forestry Sciences and Technologies, University of Florence , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-969X","authenticated-orcid":false,"given":"Erminio","family":"Monteleone","sequence":"additional","affiliation":[{"name":"Food Science and Technology, Department of Agricultural, Food, Environmental and Forestry Sciences and Technologies, University of Florence , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-7687","authenticated-orcid":false,"given":"Russell","family":"Keast","sequence":"additional","affiliation":[{"name":"CASS Food Research Centre, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University , Burwood, Victoria ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"1","key":"2025102306161734600_bjaf039-B1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/S0016-5085(97)70112-4","article-title":"The oligopeptide transporter (Pept-1) in human intestine: biology and function","volume":"113","author":"Adibi","year":"1997","journal-title":"Gastroenterology"},{"issue":"4","key":"2025102306161734600_bjaf039-B2","doi-asserted-by":"publisher","first-page":"G781","DOI":"10.1152\/ajpgi.90605.2008","article-title":"Luminal l-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats","volume":"297","author":"Akiba","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"2025102306161734600_bjaf039-B3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/separations6010014","article-title":"Total and free fatty acids analysis in milk and dairy fat","volume":"6","author":"Amores","year":"2019","journal-title":"Separations"},{"key":"2025102306161734600_bjaf039-B4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.appet.2017.08.020","article-title":"Acute effects of monosodium glutamate addition to whey protein on appetite, food intake, blood glucose, insulin and gut hormones in healthy young men","volume":"120","author":"Anderson","year":"2018","journal-title":"Appetite"},{"issue":"10","key":"2025102306161734600_bjaf039-B5","doi-asserted-by":"publisher","first-page":"8836","DOI":"10.3390\/ijms24108836","article-title":"Intestinal enteroendocrine cells: present and future druggable targets","volume":"24","author":"Atanga","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025102306161734600_bjaf039-B6","doi-asserted-by":"publisher","first-page":"1272955","DOI":"10.3389\/fnins.2023.1272955","article-title":"Enteroendocrine cell regulation of the gut-brain axis","volume":"17","author":"Barton","year":"2023","journal-title":"Front Neurosci"},{"issue":"4","key":"2025102306161734600_bjaf039-B7","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/nu13041271","article-title":"Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon","volume":"13","author":"Baumard","year":"2021","journal-title":"Nutrients"},{"issue":"50","key":"2025102306161734600_bjaf039-B8","doi-asserted-by":"publisher","first-page":"13860","DOI":"10.1021\/acs.jafc.9b03542","article-title":"Basic taste: a perceptual concept","volume":"67","author":"Beauchamp","year":"2019","journal-title":"J Agric Food Chem"},{"key":"2025102306161734600_bjaf039-B9","doi-asserted-by":"publisher","first-page":"881177","DOI":"10.3389\/fnut.2022.881177","article-title":"Extra-oral taste receptors\u2014function, disease, and perspectives","volume":"9","author":"Behrens","year":"2022","journal-title":"Front Nutr"},{"issue":"1","key":"2025102306161734600_bjaf039-B10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.physbeh.2011.02.010","article-title":"Gustatory and extragustatory functions of mammalian taste receptors","volume":"105","author":"Behrens","year":"2011","journal-title":"Physiol Behav"},{"issue":"1","key":"2025102306161734600_bjaf039-B11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/chemse\/bjl034","article-title":"Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells","volume":"32","author":"Bezen\u00e7on","year":"2007","journal-title":"Chem Senses"},{"key":"2025102306161734600_bjaf039-B12","doi-asserted-by":"publisher","first-page":"111613","DOI":"10.1016\/j.biopha.2021.111613","article-title":"A new synthetic dual agonist of GPR120\/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice","volume":"139","author":"Bianchini","year":"2021","journal-title":"Biomed Pharmacother."},{"issue":"2","key":"2025102306161734600_bjaf039-B13","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1172\/JCI78361","article-title":"Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells","volume":"125","author":"Boh\u00f3rquez","year":"2015","journal-title":"J Clin Invest"},{"issue":"1","key":"2025102306161734600_bjaf039-B14","doi-asserted-by":"publisher","first-page":"G137","DOI":"10.1152\/ajpgi.00299.2010","article-title":"Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans","volume":"300","author":"Boutry","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"2","key":"2025102306161734600_bjaf039-B15","doi-asserted-by":"publisher","first-page":"G188","DOI":"10.1152\/ajpgi.00375.2002","article-title":"High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men","volume":"284","author":"Boyd","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"Suppl 1","key":"2025102306161734600_bjaf039-B16","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1017\/S0007114513002250","article-title":"Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion","volume":"111","author":"Brennan","year":"2014","journal-title":"Br J Nutr"},{"issue":"4","key":"2025102306161734600_bjaf039-B17","doi-asserted-by":"publisher","first-page":"988S","DOI":"10.1093\/jn\/130.4.988S","article-title":"Glutamate, at the interface between amino acid and carbohydrate metabolism","volume":"130","author":"Brosnan","year":"2000","journal-title":"J Nutr"},{"issue":"9824","key":"2025102306161734600_bjaf039-B18","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/S0140-6736(11)61879-5","article-title":"TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial","volume":"379","author":"Burant","year":"2012","journal-title":"The Lancet"},{"issue":"4","key":"2025102306161734600_bjaf039-B19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrendo.2015.7","article-title":"The endocrinology of taste receptors","volume":"11","author":"Calvo","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2025102306161734600_bjaf039-B20","first-page":"203","article-title":"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann Gastroenterol"},{"issue":"1","key":"2025102306161734600_bjaf039-B21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.clnu.2008.10.008","article-title":"Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety","volume":"28","author":"Casas-Agustench","year":"2009","journal-title":"Clinical Nutrition"},{"issue":"10","key":"2025102306161734600_bjaf039-B22","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/j.cmet.2024.09.003","article-title":"GLP-1 programs the neurovascular landscape","volume":"36","author":"Chen","year":"2024","journal-title":"Cell Metab."},{"issue":"10","key":"2025102306161734600_bjaf039-B23","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s00011-015-0864-3","article-title":"Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon","volume":"64","author":"Cheshmehkani","year":"2015","journal-title":"Inflamm Res"},{"issue":"11","key":"2025102306161734600_bjaf039-B24","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00535-003-1235-3","article-title":"Secretin, 100 years later","volume":"38","author":"Chey","year":"2003","journal-title":"J Gastroenterol"},{"key":"2025102306161734600_bjaf039-B25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The epidemiology of obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"issue":"9","key":"2025102306161734600_bjaf039-B26","doi-asserted-by":"publisher","first-page":"e12551","DOI":"10.14814\/phy2.12551","article-title":"Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine","volume":"3","author":"Christensen","year":"2015","journal-title":"Physiol Rep"},{"issue":"6","key":"2025102306161734600_bjaf039-B27","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1093\/ajcn\/nqz038","article-title":"Association between taste perception and adiposity in overweight or obese older subjects with metabolic syndrome and identification of novel taste-related genes","volume":"109","author":"Coltell","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"2025102306161734600_bjaf039-B28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1017\/S0007114519002368","article-title":"A low-fat diet up-regulates expression of fatty acid taste receptor gene FFAR4 in fungiform papillae in humans: a co-twin randomised controlled trial","volume":"122","author":"Costanzo","year":"2019","journal-title":"Br J Nutr"},{"key":"2025102306161734600_bjaf039-B29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-0-387-92271-3_12","volume-title":"Handbook of behavior, food and nutrition","author":"Covasa","year":"2011"},{"issue":"2","key":"2025102306161734600_bjaf039-B30","doi-asserted-by":"publisher","first-page":"e13737","DOI":"10.1111\/nmo.13737","article-title":"Expression and function of umami receptors T1R1\/T1R3 in gastric smooth muscle","volume":"32","author":"Crowe","year":"2020","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"2025102306161734600_bjaf039-B31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/ijo.2016.199","article-title":"Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet","volume":"41","author":"Cvijanovic","year":"2017","journal-title":"Int J Obes"},{"issue":"3","key":"2025102306161734600_bjaf039-B32","doi-asserted-by":"publisher","first-page":"G271","DOI":"10.1152\/ajpgi.00074.2012","article-title":"Sensing of amino acids by the gut-expressed taste receptor T1R1","volume":"304","author":"Daly","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2025102306161734600_bjaf039-B33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cofs.2020.03.001","article-title":"Processing influences on food polyphenol profiles and biological activity","volume":"32","author":"Debelo","year":"2020","journal-title":"Curr Opin Food Sci."},{"issue":"6","key":"2025102306161734600_bjaf039-B34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00418-016-1504-x","article-title":"Chemosensory epithelial cells in the urethra: sentinels of the urinary tract","volume":"146","author":"Deckmann","year":"2016","journal-title":"Histochem Cell Biol"},{"key":"2025102306161734600_bjaf039-B35","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3389\/fphys.2017.00660","article-title":"Sulfated cholecystokinin-8 promotes CD36\u2014mediated fatty acid uptake into primary mouse duodenal enterocytes","volume":"8","author":"Demenis","year":"2017","journal-title":"Front Physiol"},{"issue":"5","key":"2025102306161734600_bjaf039-B36","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1172\/JCI21514","article-title":"CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood","volume":"115","author":"Drover","year":"2005","journal-title":"J Clin Invest"},{"issue":"4","key":"2025102306161734600_bjaf039-B37","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1210\/jcem.86.4.7386","article-title":"Glucagon-like peptide 2","volume":"86","author":"Drucker","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2025102306161734600_bjaf039-B38","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","article-title":"Mechanisms of action and therapeutic application of glucagon-like peptide-1","volume":"27","author":"Drucker","year":"2018","journal-title":"Cell Metab"},{"issue":"9","key":"2025102306161734600_bjaf039-B39","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.2337\/db08-0307","article-title":"Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion","volume":"57","author":"Edfalk","year":"2008","journal-title":"Diabetes"},{"issue":"18","key":"2025102306161734600_bjaf039-B40","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1056\/NEJMra2304578","article-title":"Physiological integration of taste and metabolism","volume":"390","author":"Egan","year":"2024","journal-title":"N Engl J Med"},{"issue":"6","key":"2025102306161734600_bjaf039-B41","doi-asserted-by":"publisher","first-page":"E948","DOI":"10.1152\/ajpendo.00220.2005","article-title":"Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid","volume":"289","author":"Feinle-Bisset","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"2025102306161734600_bjaf039-B42","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1046\/j.1365-2982.2002.00318.x","article-title":"Effects of duodenal fat, protein or mixed-nutrient infusions on epigastric sensations during sustained gastric distension in healthy humans","volume":"14","author":"Feinle","year":"2002","journal-title":"Neurogastroenterol Motil."},{"issue":"3","key":"2025102306161734600_bjaf039-B43","doi-asserted-by":"publisher","first-page":"R524","DOI":"10.1152\/ajpregu.00039.2004","article-title":"Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length","volume":"287","author":"Feltrin","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"1","key":"2025102306161734600_bjaf039-B44","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3945\/jn.111.148106","article-title":"Susceptibility to overeating affects the impact of savory or sweet drinks on satiation, reward, and food intake in nonobese women","volume":"142","author":"Finlayson","year":"2012","journal-title":"J Nutr"},{"issue":"3","key":"2025102306161734600_bjaf039-B45","doi-asserted-by":"publisher","first-page":"nzaa019","DOI":"10.1093\/cdn\/nzaa019","article-title":"Ultra-processing or oral processing? A role for energy density and eating rate in moderating energy intake from processed foods","volume":"4","author":"Forde","year":"2020","journal-title":"Curr Dev Nutr."},{"issue":"5","key":"2025102306161734600_bjaf039-B46","doi-asserted-by":"publisher","first-page":"e64579","DOI":"10.1371\/journal.pone.0064579","article-title":"Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart","volume":"8","author":"Foster","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"2025102306161734600_bjaf039-B47","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1152\/ajpregu.00126.2008","article-title":"Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats","volume":"295","author":"Fu","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"12","key":"2025102306161734600_bjaf039-B48","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrgastro.2013.180","article-title":"The gut as a sensory organ","volume":"10","author":"Furness","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"2025102306161734600_bjaf039-B49","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00702-014-1167-5","article-title":"The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells","volume":"121","author":"Ganor","year":"2014","journal-title":"J Neural Transm (Vienna)"},{"issue":"6","key":"2025102306161734600_bjaf039-B50","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/NEN.0b013e318294fd76","article-title":"Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain","volume":"72","author":"Garcia-Esparcia","year":"2013","journal-title":"J Neuropathol Exp Neurol."},{"issue":"1","key":"2025102306161734600_bjaf039-B51","doi-asserted-by":"publisher","first-page":"E28","DOI":"10.1152\/ajpendo.00306.2013","article-title":"G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro","volume":"306","author":"Gong","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2025102306161734600_bjaf039-B52","doi-asserted-by":"publisher","first-page":"E37","DOI":"10.1152\/ajpendo.00435.2016","article-title":"GPR40 reduces food intake and body weight through GLP-1","volume":"313","author":"Gorski","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"2025102306161734600_bjaf039-B53","doi-asserted-by":"publisher","first-page":"217","DOI":"10.5144\/0256-4947.2013.217","article-title":"Human biology of taste","volume":"33","author":"Gravina","year":"2013","journal-title":"Ann Saudi Med"},{"issue":"4","key":"2025102306161734600_bjaf039-B54","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0361-9230(86)90230-3","article-title":"Intraduodenal infusions of fat inhibit sham feeding in zucker rats","volume":"17","author":"Greenberg","year":"1986","journal-title":"Brain Res Bull."},{"issue":"1","key":"2025102306161734600_bjaf039-B55","doi-asserted-by":"publisher","first-page":"R110","DOI":"10.1152\/ajpregu.1990.259.1.R110","article-title":"Intraduodenal infusions of fats elicit satiety in sham-feeding rats","volume":"259","author":"Greenberg","year":"1990","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"1","key":"2025102306161734600_bjaf039-B56","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1146\/annurev-physiol-021115-105439","article-title":"Enteroendocrine cells: chemosensors in the intestinal epithelium","volume":"78","author":"Gribble","year":"2016","journal-title":"Annu Rev Physiol."},{"issue":"4","key":"2025102306161734600_bjaf039-B57","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41574-019-0168-8","article-title":"Function and mechanisms of enteroendocrine cells and gut hormones in metabolism","volume":"15","author":"Gribble","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2025102306161734600_bjaf039-B58","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/cphy.c210002","volume-title":"Comprehensive physiology","author":"Gutierrez","year":"2021"},{"issue":"1","key":"2025102306161734600_bjaf039-B59","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3390\/nu11010182","article-title":"Umami as an \u201calimentary\u201d taste. A new perspective on taste classification","volume":"11","author":"Hartley","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"2025102306161734600_bjaf039-B60","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nat Med"},{"issue":"9","key":"2025102306161734600_bjaf039-B61","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/apt.12050","article-title":"Monosodium glutamate stimulates secretion of glucagon-like peptide-1 and reduces postprandial glucose after a lipid-containing meal","volume":"36","author":"Hosaka","year":"2012","journal-title":"Aliment Pharmacol Ther."},{"issue":"3","key":"2025102306161734600_bjaf039-B62","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1053\/j.gastro.2009.05.051","article-title":"Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36","volume":"137","author":"Hsieh","year":"2009","journal-title":"Gastroenterology"},{"issue":"5","key":"2025102306161734600_bjaf039-B63","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1124\/mol.113.087783","article-title":"The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4\/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism","volume":"84","author":"Hudson","year":"2013","journal-title":"Mol Pharmacol."},{"issue":"2","key":"2025102306161734600_bjaf039-B64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.17925\/EE.2015.11.02.90","article-title":"Ghrelin\u2014physiological functions and regulation","volume":"11","author":"Ibrahim Abdalla","year":"2015","journal-title":"Eur Endocrinol"},{"issue":"2","key":"2025102306161734600_bjaf039-B65","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3390\/foods10020345","article-title":"Role of sensory appeal, nutritional quality, safety, and health determinants on convenience food choice in an academic environment","volume":"10","author":"Imtiyaz","year":"2021","journal-title":"Foods"},{"key":"2025102306161734600_bjaf039-B66","doi-asserted-by":"publisher","first-page":"170203","DOI":"10.1016\/j.peptides.2019.170203","article-title":"Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes","volume":"125","author":"Irwin","year":"2020","journal-title":"Peptides"},{"issue":"3","key":"2025102306161734600_bjaf039-B67","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/bph.12297","article-title":"TAK-875, a GPR40\/FFAR1 agonist, in combination with metformin prevents progression of diabetes and \u03b2-cell dysfunction in Zucker diabetic fatty rats","volume":"170","author":"Ito","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"3","key":"2025102306161734600_bjaf039-B68","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1210\/en.2014-1653","article-title":"Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion","volume":"156","author":"Iwasaki","year":"2015","journal-title":"Endocrinology"},{"issue":"2","key":"2025102306161734600_bjaf039-B69","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1748-1716.2011.02353.x","article-title":"Detecting sweet and umami tastes in the gastrointestinal tract","volume":"204","author":"Iwatsuki","year":"2012","journal-title":"Acta Physiol"},{"issue":"1","key":"2025102306161734600_bjaf039-B70","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/s42003-021-02765-z","article-title":"CD36 maintains the gastric mucosa and associates with gastric disease","volume":"4","author":"Jacome-Sosa","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"2025102306161734600_bjaf039-B71","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1152\/physrev.00061.2021","article-title":"A systematic review of the biological mediators of fat taste and smell","volume":"103","author":"Jaime-Lara","year":"2023","journal-title":"Physiolog Rev"},{"issue":"38","key":"2025102306161734600_bjaf039-B72","doi-asserted-by":"publisher","first-page":"15069","DOI":"10.1073\/pnas.0706890104","article-title":"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1","volume":"104","author":"Jang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2025102306161734600_bjaf039-B73","doi-asserted-by":"publisher","first-page":"e40168","DOI":"10.1371\/journal.pone.0040168","article-title":"Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein","volume":"7","author":"Janssen","year":"2012","journal-title":"PLoS One"},{"issue":"19","key":"2025102306161734600_bjaf039-B74","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.3390\/nu14194191","article-title":"Molecular mechanisms and health benefits of ghrelin: a narrative review","volume":"14","author":"Jiao","year":"2022","journal-title":"Nutrients"},{"issue":"6408","key":"2025102306161734600_bjaf039-B75","doi-asserted-by":"publisher","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"issue":"1","key":"2025102306161734600_bjaf039-B76","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev-neuro-091619-022657","article-title":"Neuropod cells: the emerging biology of gut-brain sensory transduction","volume":"43","author":"Kaelberer","year":"2020","journal-title":"Annu Rev Neurosci."},{"issue":"2","key":"2025102306161734600_bjaf039-B77","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2337\/dc12-0872","article-title":"Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes","volume":"36","author":"Kaku","year":"2013","journal-title":"Diabetes Care"},{"issue":"13","key":"2025102306161734600_bjaf039-B78","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.1002\/jsfa.10541","article-title":"l-Glutamate stimulates cholecystokinin secretion via the T1R1\/T1R3 mediated PLC\/TRPM5 transduction pathway","volume":"100","author":"Kang","year":"2020","journal-title":"J Sci Food Agric"},{"issue":"1","key":"2025102306161734600_bjaf039-B79","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1113\/jphysiol.2008.164269","article-title":"The role of peptide YY in appetite regulation and obesity","volume":"587","author":"Karra","year":"2009","journal-title":"J Physiol"},{"issue":"2","key":"2025102306161734600_bjaf039-B80","doi-asserted-by":"publisher","first-page":"R447","DOI":"10.1152\/ajpregu.00729.2002","article-title":"Importance of lipolysis in oral cavity for orosensory detection of fat","volume":"285","author":"Kawai","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2025102306161734600_bjaf039-B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.appet.2014.04.022","article-title":"Impaired oral fatty acid chemoreception is associated with acute excess energy consumption","volume":"80","author":"Keast","year":"2014","journal-title":"Appetite"},{"issue":"1","key":"2025102306161734600_bjaf039-B82","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/2044-7248-4-5","article-title":"Is fat the sixth taste primary? Evidence and implications","volume":"4","author":"Keast","year":"2015","journal-title":"Flavour"},{"issue":"2","key":"2025102306161734600_bjaf039-B83","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3390\/nu13020667","article-title":"Macronutrient sensing in the oral cavity and gastrointestinal tract: alimentary tastes","volume":"13","author":"Keast","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"2025102306161734600_bjaf039-B84","doi-asserted-by":"publisher","first-page":"G1100","DOI":"10.1152\/ajpgi.00251.2014","article-title":"Activation of the umami taste receptor (T1R1\/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon","volume":"307","author":"Kendig","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"2025102306161734600_bjaf039-B85","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1111\/dom.15563","article-title":"The obese taste bud study: objectives and study design","volume":"26","author":"Kersten","year":"2024","journal-title":"Diabetes Obes Metab."},{"issue":"1","key":"2025102306161734600_bjaf039-B86","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol Rev"},{"issue":"10","key":"2025102306161734600_bjaf039-B87","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1248\/bpb.31.1827","article-title":"Brain activation by umami substances via gustatory and visceral signaling pathways, and physiological significance","volume":"31","author":"Kondoh","year":"2008","journal-title":"Biol Pharm Bull"},{"issue":"1\u20132","key":"2025102306161734600_bjaf039-B88","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.physbeh.2008.05.010","article-title":"MSG intake suppresses weight gain, fat deposition, and plasma leptin levels in male Sprague-Dawley rats","volume":"95","author":"Kondoh","year":"2008","journal-title":"Physiol Behav"},{"issue":"2","key":"2025102306161734600_bjaf039-B89","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41430-018-0349-x","article-title":"Effect of monosodium L-glutamate (umami substance) on cognitive function in people with dementia","volume":"73","author":"Kouzuki","year":"2019","journal-title":"Eur J Clin Nutr"},{"key":"2025102306161734600_bjaf039-B90","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-031-32692-9_7","volume-title":"Umami: taste for health","author":"Kouzuki","year":"2024"},{"key":"2025102306161734600_bjaf039-B91","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.appet.2013.05.006","article-title":"Effects of dietary fatty acid composition from a high fat meal on satiety","volume":"69","author":"Kozimor","year":"2013","journal-title":"Appetite"},{"issue":"1","key":"2025102306161734600_bjaf039-B92","doi-asserted-by":"publisher","first-page":"107","DOI":"10.6133\/apjcn.042017.01","article-title":"Relationship between umami taste acuity with sweet or bitter taste acuity and food selection in Japanese women university students","volume":"27","author":"Kubota","year":"2018","journal-title":"Asia Pac J Clin Nutr"},{"issue":"11","key":"2025102306161734600_bjaf039-B93","doi-asserted-by":"publisher","first-page":"e2200775","DOI":"10.1002\/mnfr.202200775","article-title":"Activation profile of TAS2R2, the 26th human bitter taste receptor","volume":"67","author":"Lang","year":"2023","journal-title":"Mol Nutr Food Res"},{"issue":"9","key":"2025102306161734600_bjaf039-B94","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/chemse\/bju031","article-title":"Evidence that humans can taste glucose polymers","volume":"39","author":"Lapis","year":"2014","journal-title":"Chem Senses."},{"issue":"9","key":"2025102306161734600_bjaf039-B95","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/chemse\/bjw088","article-title":"Humans can taste glucose oligomers independent of the hT1R2\/hT1R3 sweet taste receptor","volume":"41","author":"Lapis","year":"2016","journal-title":"Chem Senses."},{"issue":"6","key":"2025102306161734600_bjaf039-B96","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.peptides.2011.03.017","article-title":"The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval","volume":"32","author":"Lateef","year":"2011","journal-title":"Peptides"},{"issue":"5","key":"2025102306161734600_bjaf039-B97","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.2337\/db08-1237","article-title":"GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell","volume":"58","author":"Lauffer","year":"2009","journal-title":"Diabetes"},{"issue":"5","key":"2025102306161734600_bjaf039-B98","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1017\/S000711450000060X","article-title":"The degree of saturation of fatty acids influences post-ingestive satiety","volume":"83","author":"Lawton","year":"2000","journal-title":"Br J Nutr."},{"issue":"3","key":"2025102306161734600_bjaf039-B99","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1172\/JCI72094","article-title":"Bitter and sweet taste receptors regulate human upper respiratory innate immunity","volume":"124","author":"Lee","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"2025102306161734600_bjaf039-B100","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/clpt.2012.43","article-title":"A multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel GPR40 agonist, TAK-875, in subjects with type 2 diabetes","volume":"92","author":"Leifke","year":"2012","journal-title":"Clinical Pharmacology & Therapeutics"},{"issue":"9","key":"2025102306161734600_bjaf039-B101","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1210\/jc.2005-2638","article-title":"Ghrelin stimulates gastric emptying and hunger in normal-weight humans","volume":"91","author":"Levin","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2025102306161734600_bjaf039-B102","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/molehr\/gat009","article-title":"Taste perception: from the tongue to the testis","volume":"19","author":"Li","year":"2013","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"2025102306161734600_bjaf039-B103","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1002\/fft2.407","article-title":"Taste and its receptors in human physiology: a comprehensive look","volume":"5","author":"Li","year":"2024","journal-title":"Food Front."},{"issue":"21","key":"2025102306161734600_bjaf039-B104","doi-asserted-by":"publisher","first-page":"11476","DOI":"10.3390\/ijms252111476","article-title":"Novel phenoxyalkanoic acid derivatives as free fatty acid receptor 4 agonists for treating type 2 diabetes mellitus","volume":"25","author":"Li","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"1","key":"2025102306161734600_bjaf039-B105","doi-asserted-by":"publisher","first-page":"6194","DOI":"10.1038\/s41467-023-41637-4","article-title":"The proton channel OTOP1 is a sensor for the taste of ammonium chloride","volume":"14","author":"Liang","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"2025102306161734600_bjaf039-B106","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev.physiol.59.1.221","article-title":"Cholecystokinin cells","volume":"59","author":"Liddle","year":"1997","journal-title":"Annu Rev Physiol"},{"issue":"4","key":"2025102306161734600_bjaf039-B107","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/gut.35.4.501","article-title":"Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide","volume":"35","author":"Lieverse","year":"1994","journal-title":"Gut"},{"issue":"3","key":"2025102306161734600_bjaf039-B108","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1053\/j.gastro.2010.10.012","article-title":"The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin","volume":"140","author":"Liou","year":"2011","journal-title":"Gastroenterology"},{"issue":"10","key":"2025102306161734600_bjaf039-B109","doi-asserted-by":"publisher","first-page":"G958","DOI":"10.1152\/ajpgi.00134.2014","article-title":"Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index","volume":"307","author":"Little","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"2025102306161734600_bjaf039-B110","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1017\/S0007114518001265","article-title":"Expression of the candidate fat taste receptors in human fungiform papillae and the association with fat taste function","volume":"120","author":"Liu","year":"2018","journal-title":"Br J Nutr"},{"issue":"10","key":"2025102306161734600_bjaf039-B111","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1177\/002215540104901007","article-title":"Localization of the lipid receptors CD36 and CLA-1\/SR-BI in the human gastrointestinal tract: towards the identification of receptors mediating the intestinal absorption of dietary lipids","volume":"49","author":"Lobo","year":"2001","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"2025102306161734600_bjaf039-B112","doi-asserted-by":"publisher","first-page":"G367","DOI":"10.1152\/ajpgi.00541.2011","article-title":"Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice","volume":"303","author":"Lu","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"2","key":"2025102306161734600_bjaf039-B113","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/chemse\/27.2.105","article-title":"A new specific ageusia: some humans cannot taste L-glutamate","volume":"27","author":"Lugaz","year":"2002","journal-title":"Chem Senses"},{"issue":"1","key":"2025102306161734600_bjaf039-B114","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1113\/jphysiol.2008.159616","article-title":"An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine","volume":"587","author":"Mace","year":"2009","journal-title":"J Physiol."},{"issue":"4","key":"2025102306161734600_bjaf039-B115","doi-asserted-by":"publisher","first-page":"e00155","DOI":"10.1002\/prp2.155","article-title":"Pharmacology and physiology of gastrointestinal enteroendocrine cells","volume":"3","author":"Mace","year":"2015","journal-title":"Pharmacol Res Perspect."},{"issue":"7","key":"2025102306161734600_bjaf039-B116","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3390\/nu11071638","article-title":"Food intake and satiety response after Medium-chain triglycerides ingested as solid or liquid","volume":"11","author":"Maher","year":"2019","journal-title":"Nutrients"},{"issue":"4","key":"2025102306161734600_bjaf039-B117","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3945\/ajcn.2008.27335","article-title":"Effect of fat saturation on satiety, hormone release, and food intake","volume":"89","author":"Maljaars","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"2025102306161734600_bjaf039-B118","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3945\/ajcn.113.080929","article-title":"Umami flavor enhances appetite but also increases satiety","volume":"100","author":"Masic","year":"2014","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2025102306161734600_bjaf039-B119","doi-asserted-by":"publisher","first-page":"16197","DOI":"10.1038\/s41598-020-72930-7","article-title":"Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction","volume":"10","author":"McIntyre","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"2025102306161734600_bjaf039-B120","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/ajcn\/nqy188","article-title":"Type of infant formula increases early weight gain and impacts energy balance: a randomized controlled trial","volume":"108","author":"Mennella","year":"2018","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"2025102306161734600_bjaf039-B121","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4274\/ejgg.galenos.2024.2023-12-1","article-title":"The role of hedonic hunger as a moderator and mediator in older adults obesity","volume":"6","author":"Mete","year":"2024","journal-title":"Eur J Geriatrics Gerontol"},{"issue":"1","key":"2025102306161734600_bjaf039-B122","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1254\/jphs.09R09FM","article-title":"New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract","volume":"112","author":"Miyauchi","year":"2010","journal-title":"J Pharmacol Sci"},{"issue":"7","key":"2025102306161734600_bjaf039-B123","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1053\/j.gastro.2017.01.053","article-title":"The importance of the gastrointestinal tract in controlling food intake and regulating energy balance","volume":"152","author":"Monteiro","year":"2017","journal-title":"Gastroenterology"},{"issue":"1471","key":"2025102306161734600_bjaf039-B124","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1098\/rstb.2006.1857","article-title":"Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors","volume":"361","author":"Moran","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2025102306161734600_bjaf039-B125","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.foodhyd.2016.08.003","article-title":"Revisiting the role of protein-induced satiation and satiety","volume":"68","author":"Morell","year":"2017","journal-title":"Food Hydrocoll."},{"key":"2025102306161734600_bjaf039-B126","doi-asserted-by":"publisher","first-page":"1396393","DOI":"10.3389\/fnut.2024.1396393","article-title":"The taste for health: the role of taste receptors and their ligands in the complex food\/health relationship","volume":"11","author":"Morini","year":"2024","journal-title":"Front Nutr"},{"issue":"5","key":"2025102306161734600_bjaf039-B127","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.pharep.2019.07.010","article-title":"Dietary fatty acid content influences the expression of genes involved in the lipid turnover and inflammation in mouse colon and spleen","volume":"71","author":"Mosi\u0144ska","year":"2019","journal-title":"Pharmacol Rep."},{"issue":"27","key":"2025102306161734600_bjaf039-B128","doi-asserted-by":"publisher","first-page":"19493","DOI":"10.1074\/jbc.M703330200","article-title":"CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine","volume":"282","author":"Nassir","year":"2007","journal-title":"J Biol Chem"},{"issue":"S3","key":"2025102306161734600_bjaf039-B129","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/dom.14496","article-title":"The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update","volume":"23","author":"Nauck","year":"2021","journal-title":"Diabetes Obes Metab."},{"issue":"4","key":"2025102306161734600_bjaf039-B130","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1053\/j.gastro.2006.08.012","article-title":"CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine","volume":"131","author":"Nauli","year":"2006","journal-title":"Gastroenterology"},{"issue":"4","key":"2025102306161734600_bjaf039-B131","doi-asserted-by":"publisher","first-page":"971S","DOI":"10.1093\/jn\/130.4.971S","article-title":"Reflex effects of oral, gastrointestinal and hepatoportal glutamate sensors on vagal nerve activity","volume":"130","author":"Niijima","year":"2000","journal-title":"J Nutr"},{"issue":"10","key":"2025102306161734600_bjaf039-B132","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.2337\/db21-0451","article-title":"SCO-267, a GPR40 full agonist, stimulates islet and gut hormone secretion and improves glycemic control in humans","volume":"70","author":"Nishizaki","year":"2021","journal-title":"Diabetes"},{"issue":"9","key":"2025102306161734600_bjaf039-B133","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.3390\/nu12092493","article-title":"The effect of high-fat diet-induced obesity on the expression of nutrient chemosensors in the mouse stomach and the gastric ghrelin cell","volume":"12","author":"Nunez-Salces","year":"2020","journal-title":"Nutrients"},{"issue":"12","key":"2025102306161734600_bjaf039-B134","doi-asserted-by":"publisher","first-page":"e13944","DOI":"10.1111\/nmo.13944","article-title":"Nutrient-sensing components of the mouse stomach and the gastric ghrelin cell","volume":"32","author":"Nunez-Salces","year":"2020","journal-title":"Neurogastroenterol Motil."},{"key":"2025102306161734600_bjaf039-B135","doi-asserted-by":"publisher","first-page":"170673","DOI":"10.1016\/j.peptides.2021.170673","article-title":"The secretion of total and acyl ghrelin from the mouse gastric mucosa: role of nutrients and the lipid chemosensors FFAR4 and CD36","volume":"146","author":"Nunez-Salces","year":"2021","journal-title":"Peptides"},{"issue":"4","key":"2025102306161734600_bjaf039-B136","doi-asserted-by":"publisher","first-page":"R1042","DOI":"10.1152\/ajpregu.00039.2005","article-title":"Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects","volume":"289","author":"Oesch","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2025102306161734600_bjaf039-B137","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.biopha.2018.10.172","article-title":"Dietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice","volume":"109","author":"Onaolapo","year":"2019","journal-title":"Biomed Pharmacother."},{"issue":"1","key":"2025102306161734600_bjaf039-B138","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1183\/09031936.00077712","article-title":"Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics","volume":"42","author":"Orsmark-Pietras","year":"2013","journal-title":"Eur Respir J"},{"key":"2025102306161734600_bjaf039-B139","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.peptides.2014.01.008","article-title":"CCK-58 elicits both satiety and satiation in rats while CCK-8 elicits only satiation","volume":"54","author":"Overduin","year":"2014","journal-title":"Peptides"},{"issue":"10","key":"2025102306161734600_bjaf039-B140","doi-asserted-by":"publisher","first-page":"e0186033","DOI":"10.1371\/journal.pone.0186033","article-title":"GPR40 partial agonists and AgoPAMs: differentiating effects on glucose and hormonal secretions in the rodent","volume":"12","author":"Pachanski","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"2025102306161734600_bjaf039-B141","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00125-008-1202-x","article-title":"Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells","volume":"52","author":"Parker","year":"2008","journal-title":"Diabetologia"},{"issue":"4\u20135","key":"2025102306161734600_bjaf039-B142","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.physbeh.2007.12.015","article-title":"Adaptation of lipid-induced satiation is not dependent on caloric density in rats","volume":"93","author":"Paulino","year":"2008","journal-title":"Physiol Behav."},{"issue":"2","key":"2025102306161734600_bjaf039-B143","doi-asserted-by":"publisher","first-page":"e88227","DOI":"10.1371\/journal.pone.0088227","article-title":"Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion","volume":"9","author":"Paulsen","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"2025102306161734600_bjaf039-B144","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.3390\/nu10101529","article-title":"Effects of obesity and gastric bypass surgery on nutrient sensors, endocrine cells, and mucosal innervation of the mouse colon","volume":"10","author":"Peiris","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"2025102306161734600_bjaf039-B145","doi-asserted-by":"publisher","first-page":"R668","DOI":"10.1152\/ajpregu.00606.2005","article-title":"Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men","volume":"290","author":"Pilichiewicz","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"2025102306161734600_bjaf039-B146","doi-asserted-by":"publisher","first-page":"E899","DOI":"10.1152\/ajpendo.00116.2012","article-title":"Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells","volume":"303","author":"Poreba","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025102306161734600_bjaf039-B147","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3389\/fphys.2019.00652","article-title":"Altered salivary flow, protein composition, and rheology following taste and TRP stimulation in older adults","volume":"10","author":"Pushpass","year":"2019","journal-title":"Front Physiol"},{"issue":"4","key":"2025102306161734600_bjaf039-B148","doi-asserted-by":"publisher","first-page":"978S","DOI":"10.1093\/jn\/130.4.978S","article-title":"Intestinal glutamate metabolism","volume":"130","author":"Reeds","year":"2000","journal-title":"J Nutr"},{"key":"2025102306161734600_bjaf039-B149","doi-asserted-by":"publisher","first-page":"1028261","DOI":"10.3389\/fnut.2022.1028261","article-title":"Enhanced sweet taste perception in obesity: joint analysis of gustatory data from multiple studies","volume":"9","author":"Ribeiro","year":"2022","journal-title":"Front Nutr"},{"issue":"4","key":"2025102306161734600_bjaf039-B150","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/ijo.2010.155","article-title":"Taste, olfactory and food texture reward processing in the brain and obesity","volume":"35","author":"Rolls","year":"2011","journal-title":"Int J Obes"},{"issue":"4","key":"2025102306161734600_bjaf039-B151","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1097\/MCO.0b013e328302c9b0","article-title":"Gut\u2013brain axis","volume":"11","author":"Romijn","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care."},{"issue":"5","key":"2025102306161734600_bjaf039-B152","doi-asserted-by":"publisher","first-page":"G792","DOI":"10.1152\/ajpgi.00074.2006","article-title":"Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon","volume":"291","author":"Rozengurt","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"2025102306161734600_bjaf039-B153","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1093\/chemse\/bjv036","article-title":"Oleogustus: the unique taste of fat","volume":"40","author":"Running","year":"2015","journal-title":"Chem Senses"},{"issue":"2","key":"2025102306161734600_bjaf039-B154","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/chemse\/bjw116","article-title":"Degree of free fatty acid saturation influences chocolate rejection in human assessors","volume":"42","author":"Running","year":"2017","journal-title":"Chem Senses."},{"issue":"1","key":"2025102306161734600_bjaf039-B155","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/00075197-200501000-00007","article-title":"Skeletal muscle glutamate metabolism in health and disease: state of the art","volume":"8","author":"Rutten","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"2025102306161734600_bjaf039-B156","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3945\/ajcn.112.038133","article-title":"Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men123","volume":"96","author":"Ryan","year":"2012","journal-title":"Am J Clin Nutr."},{"issue":"Suppl 1","key":"2025102306161734600_bjaf039-B157","doi-asserted-by":"publisher","first-page":"614-P","DOI":"10.2337\/db24-614-P","article-title":"614-P: effects of umami stimulation on oral environment of type 2 diabetes Mellitus patients","volume":"73","author":"Sakai","year":"2024","journal-title":"Diabetes"},{"issue":"3","key":"2025102306161734600_bjaf039-B158","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0196-9781(01)00633-7","article-title":"Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract","volume":"23","author":"Sakata","year":"2002","journal-title":"Peptides"},{"issue":"1","key":"2025102306161734600_bjaf039-B159","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2044-7248-4-14","article-title":"Taste receptors in the gastrointestinal system","volume":"4","author":"San Gabriel","year":"2015","journal-title":"Flavour"},{"issue":"6","key":"2025102306161734600_bjaf039-B160","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.febslet.2007.02.016","article-title":"mGluR1 in the fundic glands of rat stomach","volume":"581","author":"San Gabriel","year":"2007","journal-title":"FEBS Lett"},{"issue":"3","key":"2025102306161734600_bjaf039-B161","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.bbrc.2008.11.060","article-title":"The calcium-sensing receptor in taste tissue","volume":"378","author":"San Gabriel","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"2025102306161734600_bjaf039-B162","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1210\/en.2017-00090","article-title":"Long-chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice","volume":"158","author":"Sankoda","year":"2017","journal-title":"Endocrinology"},{"issue":"6","key":"2025102306161734600_bjaf039-B163","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1111\/jdi.13059","article-title":"Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion","volume":"10","author":"Sankoda","year":"2019","journal-title":"J Diabetes Investig."},{"issue":"1","key":"2025102306161734600_bjaf039-B164","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s13104-017-2835-y","article-title":"Homeostatic modulation on unconscious hedonic responses to food","volume":"10","author":"Sato","year":"2017","journal-title":"BMC Res Notes."},{"issue":"4","key":"2025102306161734600_bjaf039-B165","doi-asserted-by":"publisher","first-page":"e95177","DOI":"10.1371\/journal.pone.0095177","article-title":"Development of an umami taste sensitivity test and its clinical use","volume":"9","author":"Satoh-Kuriwada","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"2025102306161734600_bjaf039-B166","first-page":"158","article-title":"Effect of taste and smell on secretion rate of salivary IgA in elderly and young persons","volume":"3","author":"Schiffman","year":"1999","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"2025102306161734600_bjaf039-B167","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cmet.2008.08.005","article-title":"The lipid messenger OEA links dietary fat intake to satiety","volume":"8","author":"Schwartz","year":"2008","journal-title":"Cell Metab"},{"issue":"8","key":"2025102306161734600_bjaf039-B168","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1096\/fj.13-247536","article-title":"Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption","volume":"28","author":"Sekar","year":"2014","journal-title":"FASEB J."},{"issue":"2","key":"2025102306161734600_bjaf039-B169","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1136\/gut.31.2.158","article-title":"Effect of prefeeding lipid on food intake and satiety in man","volume":"31","author":"Sepple","year":"1990","journal-title":"Gut"},{"key":"2025102306161734600_bjaf039-B170","doi-asserted-by":"publisher","first-page":"568991","DOI":"10.3389\/fnut.2020.568991","article-title":"Short chain fatty acids enhance expression and activity of the umami taste receptor in enteroendocrine cells via a G\u03b1i\/o pathway","volume":"7","author":"Shackley","year":"2020","journal-title":"Front Nutr"},{"issue":"5944","key":"2025102306161734600_bjaf039-B171","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1126\/science.1173869","article-title":"Motile cilia of human airway epithelia are chemosensory","volume":"325","author":"Shah","year":"2009","journal-title":"Science"},{"issue":"1","key":"2025102306161734600_bjaf039-B172","doi-asserted-by":"publisher","first-page":"C210","DOI":"10.1152\/ajpcell.00209.2011","article-title":"TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1","volume":"302","author":"Shah","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"2025102306161734600_bjaf039-B173","doi-asserted-by":"publisher","first-page":"e0205322","DOI":"10.1371\/journal.pone.0205322","article-title":"Personalized expression of bitter \u201ctaste\u201d receptors in human skin","volume":"13","author":"Shaw","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"2025102306161734600_bjaf039-B174","doi-asserted-by":"publisher","first-page":"G298","DOI":"10.1152\/ajpgi.00457.2011","article-title":"Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents","volume":"303","author":"Shimotoyodome","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"1","key":"2025102306161734600_bjaf039-B175","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev-physiol-021317-121332","article-title":"Chemoreceptors in the gut","volume":"80","author":"Steensels","year":"2018","journal-title":"Annu Rev Physiol"},{"issue":"10","key":"2025102306161734600_bjaf039-B176","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/oby.21202","article-title":"Hunger and satiety responses to high-fat meals of varying fatty acid composition in women with obesity","volume":"23","author":"Stevenson","year":"2015","journal-title":"Obesity"},{"key":"2025102306161734600_bjaf039-B177","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.nut.2017.03.008","article-title":"Hunger and satiety responses to high-fat meals after a high-polyunsaturated fat diet: a randomized trial","volume":"41","author":"Stevenson","year":"2017","journal-title":"Nutrition"},{"issue":"6","key":"2025102306161734600_bjaf039-B178","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/ijo.2011.155","article-title":"Recent fat intake modulates fat taste sensitivity in lean and overweight subjects","volume":"36","author":"Stewart","year":"2012","journal-title":"Int J Obes"},{"issue":"4","key":"2025102306161734600_bjaf039-B179","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3945\/ajcn.110.007583","article-title":"Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men","volume":"93","author":"Stewart","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"2025102306161734600_bjaf039-B180","doi-asserted-by":"publisher","first-page":"6963","DOI":"10.1007\/s11033-023-08535-w","article-title":"The role of GLUT2 in glucose metabolism in multiple organs and tissues","volume":"50","author":"Sun","year":"2023","journal-title":"Mol Biol Rep"},{"issue":"10","key":"2025102306161734600_bjaf039-B181","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3945\/jn.115.215483","article-title":"Dietary lipids inform the gut and brain about meal arrival via CD36-mediated signal transduction","volume":"145","author":"Sundaresan","year":"2015","journal-title":"J Nutr"},{"issue":"3","key":"2025102306161734600_bjaf039-B182","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.ajcnut.2023.06.011","article-title":"Intraduodenal nutrient infusion differentially alters intestinal nutrient sensing, appetite, and satiety responses in lean and obese subjects","volume":"118","author":"Sundaresan","year":"2023","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"2025102306161734600_bjaf039-B183","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1096\/fj.12-217703","article-title":"CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin","volume":"27","author":"Sundaresan","year":"2013","journal-title":"FASEB J."},{"issue":"6","key":"2025102306161734600_bjaf039-B184","doi-asserted-by":"publisher","first-page":"246","DOI":"10.2183\/pjab.95.017","article-title":"Glutamate as intracellular and extracellular signals in pancreatic islet functions","volume":"95","author":"Takahashi","year":"2019","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"4\u20136","key":"2025102306161734600_bjaf039-B185","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00210-007-0200-8","article-title":"Free fatty acids induce cholecystokinin secretion through GPR120","volume":"377","author":"Tanaka","year":"2008","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4\u20136","key":"2025102306161734600_bjaf039-B186","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00210-007-0250-y","article-title":"Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic \u03b2 cells","volume":"377","author":"Tanaka","year":"2008","journal-title":"Naunyn-Schmied Arch Pharmacol"},{"issue":"11","key":"2025102306161734600_bjaf039-B187","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1292\/jvms.66.1311","article-title":"Expression of the sweet receptor protein, T1R3, in the human liver and pancreas","volume":"66","author":"Taniguchi","year":"2004","journal-title":"J Vet Med Sci"},{"issue":"1","key":"2025102306161734600_bjaf039-B188","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00424-020-02464-4","article-title":"Taste transduction and channel synapses in taste buds","volume":"473","author":"Taruno","year":"2021","journal-title":"Pflugers Arch"},{"issue":"21","key":"2025102306161734600_bjaf039-B189","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1016\/j.cub.2019.08.077","article-title":"Cellular and neural responses to sour stimuli require the proton channel otop1","volume":"29","author":"Teng","year":"2019","journal-title":"Curr Biol"},{"issue":"1","key":"2025102306161734600_bjaf039-B190","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/ajcn\/nqac068","article-title":"Texture-based differences in eating rate influence energy intake for minimally processed and ultra-processed meals","volume":"116","author":"Teo","year":"2022","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2025102306161734600_bjaf039-B191","doi-asserted-by":"publisher","first-page":"e00187","DOI":"10.1002\/phy2.187","article-title":"Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects","volume":"2","author":"Teramoto","year":"2014","journal-title":"Physiol Rep."},{"issue":"6","key":"2025102306161734600_bjaf039-B192","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1039\/C9FO00228F","article-title":"Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1\/T1R3 using an in vitro porcine jejunum model","volume":"10","author":"Tian","year":"2019","journal-title":"Food Funct"},{"issue":"1","key":"2025102306161734600_bjaf039-B193","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1749-6632.2009.03898.x","article-title":"Clinical trial of glutamate for the improvement of nutrition and health in the elderly","volume":"1170","author":"Tomoe","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"2025102306161734600_bjaf039-B194","doi-asserted-by":"publisher","first-page":"102477","DOI":"10.1016\/j.npep.2024.102477","article-title":"Enteroendocrine cell-derived peptide YY signalling is stimulated by pinolenic acid or intralipid and involves coactivation of fatty acid receptors FFA1, FFA4 and GPR119","volume":"108","author":"Tough","year":"2024","journal-title":"Neuropeptides"},{"issue":"10","key":"2025102306161734600_bjaf039-B195","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1248\/bpb.31.1852","article-title":"A possible application of monosodium glutamate to nutritional care for elderly people","volume":"31","author":"Toyama","year":"2008","journal-title":"Biol Pharm Bull"},{"issue":"11\u201312","key":"2025102306161734600_bjaf039-B196","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.bbaexp.2007.08.003","article-title":"CCAAT\/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1","volume":"1769","author":"Toyono","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2025102306161734600_bjaf039-B197","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1124\/jpet.111.183772","article-title":"TAK-875, an orally available G protein-coupled receptor 40\/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats","volume":"339","author":"Tsujihata","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"2025102306161734600_bjaf039-B198","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ajpath.2014.09.010","article-title":"Tumor necrosis factor \u03b1 decreases glucagon-like peptide-2 expression by up-regulating G-protein\u2013coupled receptor 120 in crohn disease","volume":"185","author":"Tsukahara","year":"2015","journal-title":"Am J Pathol."},{"issue":"11","key":"2025102306161734600_bjaf039-B199","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1097\/WNR.0b013e328307c414","article-title":"Forebrain activation induced by postoral nutritive substances in rats","volume":"19","author":"Tsurugizawa","year":"2008","journal-title":"Neuroreport"},{"issue":"6","key":"2025102306161734600_bjaf039-B200","doi-asserted-by":"publisher","first-page":"G1163","DOI":"10.1152\/ajpgi.00587.2005","article-title":"Luminal amino acid sensing in the rat gastric mucosa","volume":"291","author":"Uneyama","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"2025102306161734600_bjaf039-B201","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3945\/ajcn.115.113266","article-title":"Intraduodenal infusion of a combination of tastants decreases food intake in humans","volume":"102","author":"van Avesaat","year":"2015","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"2025102306161734600_bjaf039-B202","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700804","article-title":"Obesity impairs oligopeptide\/amino acid-induced ghrelin release and smooth muscle contractions in the human proximal stomach","volume":"62","author":"Vancleef","year":"2018","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"2025102306161734600_bjaf039-B203","doi-asserted-by":"publisher","first-page":"15725","DOI":"10.1038\/srep15725","article-title":"Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell","volume":"5","author":"Vancleef","year":"2015","journal-title":"Sci Rep"},{"key":"2025102306161734600_bjaf039-B204","first-page":"29","article-title":"Effect of glutamate and combined with inosine monophosphate on gastric secretion","volume":"3","author":"Vasilevskaia","year":"1993","journal-title":"Vopr Pitan"},{"issue":"4","key":"2025102306161734600_bjaf039-B205","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3945\/ajcn.111.024919","article-title":"Infant regulation of intake: the effect of free glutamate content in infant formulas1234","volume":"95","author":"Ventura","year":"2012","journal-title":"Am J Clin Nutr."},{"issue":"4","key":"2025102306161734600_bjaf039-B206","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1108\/00346651211248638","article-title":"Free amino acid content in infant formulas","volume":"42","author":"Ventura","year":"2012","journal-title":"Nutr Food Sci"},{"issue":"20","key":"2025102306161734600_bjaf039-B207","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1080\/10408398.2023.2177610","article-title":"The gut odorant receptor and taste receptor make sense of dietary components: a focus on gut hormone secretion","volume":"64","author":"Wang","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"10","key":"2025102306161734600_bjaf039-B208","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.1039\/D1RA08925K","article-title":"Thiazolidinedione derivatives as novel GPR120 agonists for the treatment of type 2 diabetes","volume":"12","author":"Wang","year":"2022","journal-title":"RSC Adv."},{"key":"2025102306161734600_bjaf039-B209","doi-asserted-by":"publisher","first-page":"1090.2","DOI":"10.1096\/fasebj.31.1_supplement.1090","article-title":"Expression of putative umami\/L-amino acid receptors in mouse intestine and colon, and a murine enteroendocrine cell line","volume":"31","author":"Wang","year":"2017","journal-title":"FASEB J."},{"issue":"2","key":"2025102306161734600_bjaf039-B210","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/foods8020071","article-title":"Influence of monosodium glutamate and its substitutes on sensory characteristics and consumer perceptions of chicken soup","volume":"8","author":"Wang","year":"2019","journal-title":"Foods"},{"issue":"3","key":"2025102306161734600_bjaf039-B211","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1136\/gut.29.3.306","article-title":"Comparisons of the effects on satiety and eating behaviour of infusion of lipid into the different regions of the small intestine","volume":"29","author":"Welch","year":"1988","journal-title":"Gut"},{"key":"2025102306161734600_bjaf039-B212","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fphys.2015.00053","article-title":"High fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach","volume":"6","author":"Widmayer","year":"2015","journal-title":"Front Physiol"},{"issue":"10","key":"2025102306161734600_bjaf039-B213","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/ijo.2011.216","article-title":"Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients","volume":"36","author":"Widmayer","year":"2012","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"2025102306161734600_bjaf039-B214","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1210\/endrev\/bnaf006","article-title":"Glucose-dependent insulinotropic polypeptide in incretin physiology: role in health and disease","volume":"46","author":"Wolfe","year":"2025","journal-title":"Endocr Rev."},{"issue":"4","key":"2025102306161734600_bjaf039-B215","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3168\/jds.S0022-0302(84)81380-6","article-title":"Quantification of Major free fatty acids in several cheese varieties1","volume":"67","author":"Woo","year":"1984","journal-title":"J Dairy Sci."},{"author":"World Health Organization","key":"2025102306161734600_bjaf039-B216"},{"issue":"22","key":"2025102306161734600_bjaf039-B217","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1080\/10408398.2021.2021388","article-title":"Sensation of dietary nutrients by gut taste receptors and its mechanisms","volume":"63","author":"Xie","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"2025102306161734600_bjaf039-B218","doi-asserted-by":"publisher","first-page":"921S","DOI":"10.1093\/jn\/130.4.921S","article-title":"Umami and food palatability","volume":"130","author":"Yamaguchi","year":"2000","journal-title":"J Nutr."},{"key":"2025102306161734600_bjaf039-B219","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-031-32692-9_5","volume-title":"Umami: taste for Health","author":"Yeomans","year":"2024"},{"issue":"1","key":"2025102306161734600_bjaf039-B220","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3945\/ajcn.2008.26180","article-title":"Monosodium l-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying","volume":"89","author":"Zai","year":"2009","journal-title":"Am J Clin Nutr."}],"container-title":["Chemical Senses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/chemse\/advance-article-pdf\/doi\/10.1093\/chemse\/bjaf039\/64358434\/bjaf039.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/chemse\/article-pdf\/doi\/10.1093\/chemse\/bjaf039\/64358434\/bjaf039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/chemse\/article-pdf\/doi\/10.1093\/chemse\/bjaf039\/64358434\/bjaf039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:16:24Z","timestamp":1761214584000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/chemse\/article\/doi\/10.1093\/chemse\/bjaf039\/8262680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":220,"URL":"https:\/\/doi.org\/10.1093\/chemse\/bjaf039","relation":{},"ISSN":["0379-864X","1464-3553"],"issn-type":[{"type":"print","value":"0379-864X"},{"type":"electronic","value":"1464-3553"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"bjaf039"}}