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Insects, the most biodiverse class of animals, play crucial roles in ecosystems and have an extensive chemosensory repertoire. At the heart of insect gustation lie the gustatory receptors (GRs), a large and remarkably diverse family of proteins characterized by their seven-transmembrane domain structure and tetrameric stoichiometry. These receptors are phylogenetically distinct from the taste receptors present in most other animal groups, including mammals. Functionally, GRs operate as ligand-gated cation channels. Upon binding to specific chemical compounds (tastants), these receptors undergo conformational changes that lead to the opening of ion-conducting channels in the neuronal membrane, ultimately triggering neuronal activation and initiating the perception of taste. Recent advancements in structural biology, particularly the use of cryo-electron microscopy, have enabled the visualization of the three-dimensional structure of several insect GRs that detect sugars. These structures, in unbound and ligand-bound states, have begun to reveal the principles of sugar recognition and discrimination. Here, we highlight recent advances in our understanding of insect GRs.<\/jats:p>","DOI":"10.1093\/chemse\/bjaf053","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:03:19Z","timestamp":1762520599000},"source":"Crossref","is-referenced-by-count":1,"title":["A structural perspective on insect gustatory receptors"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-0488","authenticated-orcid":false,"given":"Jo\u00e3o Victor","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine , 333 Cedar Street, P.O. Box 208066, New Haven, CT 06520 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-0088","authenticated-orcid":false,"given":"Raquel A","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine , 333 Cedar Street, P.O. Box 208066, New Haven, CT 06520 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-7774","authenticated-orcid":false,"given":"Joel A","family":"Butterwick","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine , 333 Cedar Street, P.O. 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