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High-resolution MRI scans of 118 healthy participants (mean age 28.47 \u00b1 8.20) were manually segmented by multiple observers. Interobserver reliability was generally acceptable, with OS depth and APD showing excellent agreement. Single-observer assessments were sufficient for group-level OB morphology, but caution was advised when interpreting individual cases. Besides, right OS depth and left height decreased with age in normosmic participants, and odor discrimination was positively associated with left OB width. People with deeper right OS depth had bigger right volume and longer APD. No correlations were found between olfactory function and OB morphological parameters. OS depth was consistently deeper on the right side, supporting hemispheric asymmetry. OB shape was most often oval (\u224878%). Over 70% of the subjects showed left-right consistency in OB shape, but the Cohen's \u03ba value indicated only slight (below moderate) agreement, suggesting that left\u2013right agreement was limited. In conclusion, we presented a standardized multiobserver segmentation and measurement workflow that enabled reliable assessment of OB structure and OS depth, and offered a comprehensive characterization of OB and OS depth morphology in normosmia.<\/jats:p>","DOI":"10.1093\/chemse\/bjag008","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:54:41Z","timestamp":1774378481000},"source":"Crossref","is-referenced-by-count":3,"title":["Human olfactory bulb morphometry and olfactory sulcus depth measurement in normosmia"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-9995","authenticated-orcid":false,"given":"Shubin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universit\u00e4t Dresden , Fetscherstrasse 74, Dresden 01307 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-3476","authenticated-orcid":false,"given":"Kwangsu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universit\u00e4t Dresden , Fetscherstrasse 74, Dresden 01307 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-4698","authenticated-orcid":false,"given":"Akshita","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universit\u00e4t Dresden , Fetscherstrasse 74, Dresden 01307 ,","place":["Germany"]},{"name":"Division of Intramural Research, National Smell and Taste Center, National Institute on Deafness and Other Communication Disorders (NIDCD), NIH , Bethesda, MD 20892 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-0183","authenticated-orcid":false,"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universit\u00e4t Dresden , Fetscherstrasse 74, Dresden 01307 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"3","key":"2026062406512886600_bjag008-B1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0028-3932(83)90045-3","article-title":"The effect of right temporal lobe lesions on matching of smells","volume":"21","author":"Abraham","year":"1983","journal-title":"Neuropsychologia"},{"issue":"2","key":"2026062406512886600_bjag008-B2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejrad.2007.02.031","article-title":"Interobserver-variability of lung nodule volumetry considering different segmentation algorithms and observer training levels","volume":"64","author":"Bolte","year":"2007","journal-title":"Eur J Radiol."},{"issue":"7","key":"2026062406512886600_bjag008-B3","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.acra.2011.02.018","article-title":"Reproducibility and repeatability of volumetric measurements for olfactory bulb volumetry: which method is appropriate? 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