{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:50:38Z","timestamp":1778277038832,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"DOI":"10.1093\/chemse\/bji046","type":"journal-article","created":{"date-parts":[[2005,7,20]],"date-time":"2005-07-20T00:14:53Z","timestamp":1121818493000},"page":"531-538","source":"Crossref","is-referenced-by-count":31,"title":["Expression of Amiloride-sensitive Epithelial Sodium Channels in Mouse Taste Cells after Chorda Tympani Nerve Crush"],"prefix":"10.1093","volume":"30","author":[{"given":"Noriatsu","family":"Shigemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu Ahammad S.","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Sadamitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yasumatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,19]]},"reference":[{"key":"key\n\t\t\t\t20171011233331_BIB1","doi-asserted-by":"crossref","unstructured":"Canessa, C.M., Horisberger, J.D. and Rossier, B.C. (1993) Epithelial sodium channel related to proteins involved in neurodegeneration. Nature, 361, 467\u2013470.","DOI":"10.1038\/361467a0"},{"key":"key\n\t\t\t\t20171011233331_BIB2","doi-asserted-by":"crossref","unstructured":"Canessa, C.M., Schild, L., Buell, G., Thorens, B., Gautschi, I., Horisberger, J.D. and Rossier, B.C. (1994) Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature, 367, 463\u2013467.","DOI":"10.1038\/367463a0"},{"key":"key\n\t\t\t\t20171011233331_BIB3","doi-asserted-by":"crossref","unstructured":"Doolin, R.E. and Gilbertson, T.A. (1996) Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue. J. Gen. Physiol., 107, 545\u2013554.","DOI":"10.1085\/jgp.107.4.545"},{"key":"key\n\t\t\t\t20171011233331_BIB4","doi-asserted-by":"crossref","unstructured":"Elliott, E.J. and Simon, S.A. (1990) The anion in salt taste: a possible role for paracellular pathways. Brain Res., 535, 9\u201317.","DOI":"10.1016\/0006-8993(90)91817-Z"},{"key":"key\n\t\t\t\t20171011233331_BIB5","doi-asserted-by":"crossref","unstructured":"Formaker, B.K. and Hill, D.L. (1991) Lack of amiloride sensitivity in SHR and WKY glossopharyngeal taste responses to NaCl. Physiol. Behav., 50, 765\u2013769.","DOI":"10.1016\/0031-9384(91)90015-G"},{"key":"key\n\t\t\t\t20171011233331_BIB6","doi-asserted-by":"crossref","unstructured":"Hettinger, T.P. and Frank, M.E. (1990) Specificity of amiloride inhibition of hamster taste responses. Brain Res., 513, 24\u201334.","DOI":"10.1016\/0006-8993(90)91085-U"},{"key":"key\n\t\t\t\t20171011233331_BIB7","doi-asserted-by":"crossref","unstructured":"Hill, D.L. and Bour, T.C. (1985) Addition of functional amiloride-sensitive components to the receptor membrane: a possible mechanism for altered taste responses during development. Brain Res., 352, 310\u2013313.","DOI":"10.1016\/0165-3806(85)90121-X"},{"key":"key\n\t\t\t\t20171011233331_BIB8","doi-asserted-by":"crossref","unstructured":"Kinnamon, S.C., Dionne, V.E. and Beam, K.G. (1988) Apical localization of K+ channels in taste cells provides the basis for sour taste transduction. Proc. Natl Acad. Sci. USA, 85, 7023\u20137027.","DOI":"10.1073\/pnas.85.18.7023"},{"key":"key\n\t\t\t\t20171011233331_BIB9","doi-asserted-by":"crossref","unstructured":"Kossel, A.H., McPheeters, M., Lin, W. and Kinnamon, S.C. (1997) Development of membrane properties in taste cells of fungiform papillae: functional evidence for early presence of amiloride-sensitive sodium channels. J. Neurosci., 17, 9634\u20139641.","DOI":"10.1523\/JNEUROSCI.17-24-09634.1997"},{"key":"key\n\t\t\t\t20171011233331_BIB10","doi-asserted-by":"crossref","unstructured":"Kretz, O., Barbry, P., Bock, R. and Lindemann, B. (1999) Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J. Histochem. Cytochem., 47, 51\u201364.","DOI":"10.1177\/002215549904700106"},{"key":"key\n\t\t\t\t20171011233331_BIB11","doi-asserted-by":"crossref","unstructured":"Li, X.J., Blackshaw, S. and Snyder, S.H. (1994) Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception. Proc. Natl Acad. Sci. USA, 91, 1814\u20131818.","DOI":"10.1073\/pnas.91.5.1814"},{"key":"key\n\t\t\t\t20171011233331_BIB12","doi-asserted-by":"crossref","unstructured":"Lin, W., Finger, T.E., Rossier, B.C. and Kinnamon, S.C. (1999) Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone. J. Comp. Neurol., 405, 406\u2013420.","DOI":"10.1002\/(SICI)1096-9861(19990315)405:3<406::AID-CNE10>3.0.CO;2-F"},{"key":"key\n\t\t\t\t20171011233331_BIB13","doi-asserted-by":"crossref","unstructured":"Lingueglia, E., Voilley, N., Waldmann, R., Lazdunski, M. and Barbry, P. (1993) Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett., 318, 95\u201399.","DOI":"10.1016\/0014-5793(93)81336-X"},{"key":"key\n\t\t\t\t20171011233331_BIB14","doi-asserted-by":"crossref","unstructured":"Lyall, V., Heck, G.L., Vinnikova, A.K., Ghosh, S., Phan, T.H., Alam, R.I., Russell, O.F., Malik, S.A., Bigbee, J.W. and DeSimone, J.A. (2004) The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. J. Physiol., 558, 147\u2013159.","DOI":"10.1113\/jphysiol.2004.065656"},{"key":"key\n\t\t\t\t20171011233331_BIB15","doi-asserted-by":"crossref","unstructured":"Mbiene, J.P. and Roberts, J.D. (2003) Distribution of keratin 8-containing cell clusters in mouse embryonic tongue: evidence for a prepattern for taste bud development. J. Comp. Neurol., 457, 111\u2013122.","DOI":"10.1002\/cne.10551"},{"key":"key\n\t\t\t\t20171011233331_BIB16","doi-asserted-by":"crossref","unstructured":"McCluskey, L.P. and Hill, D.L. (2002) Sensitive periods for the effect of dietary sodium restriction on intact and denervated taste receptor cells. Am. J. Physiol. Regul. Integr. Comp. Physiol., 283, R1275\u20131284.","DOI":"10.1152\/ajpregu.00282.2002"},{"key":"key\n\t\t\t\t20171011233331_BIB17","doi-asserted-by":"crossref","unstructured":"McLaughlin, S.K., McKinnon, P.J. and Margolskee, R.F. (1992) Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature, 357, 563\u2013569.","DOI":"10.1038\/357563a0"},{"key":"key\n\t\t\t\t20171011233331_BIB18","doi-asserted-by":"crossref","unstructured":"Miura, H., Kato, H., Kusakabe, Y., Tagami, M., Miura-Ohnuma, J., Ninomiya, Y. and Hino, A. (2004) A strong nerve dependence of Sonic hedghog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells. Chem. Senses, 29, 823\u2013831.","DOI":"10.1093\/chemse\/bjh248"},{"key":"key\n\t\t\t\t20171011233331_BIB19","doi-asserted-by":"crossref","unstructured":"Miyamoto, T., Fujiyama, R., Okada, Y. and Sato, T. (1998) Sour transduction involves activation of NPPB-sensitive conductance in mouse taste cells. J. Neurophysiol., 80, 1852\u20131859.","DOI":"10.1152\/jn.1998.80.4.1852"},{"key":"key\n\t\t\t\t20171011233331_BIB20","doi-asserted-by":"crossref","unstructured":"Miyamoto, T., Miyazaki, T., Fujiyama, R., Okada, Y. and Sato, T. (2001) Differential transduction mechanisms underlying NaCl- and KCl-induced responses in mouse taste cells. Chem. Senses, 26, 67\u201377.","DOI":"10.1093\/chemse\/26.1.67"},{"key":"key\n\t\t\t\t20171011233331_BIB21","doi-asserted-by":"crossref","unstructured":"Ninomiya, Y. (1996) Salt taste responses of mouse chorda tympani neurons: evidence for existence of two different amiloride-sensitive receptor components for NaCl with different temperature dependencies. J. Neurophysiol., 76, 3550\u20133554.","DOI":"10.1152\/jn.1996.76.5.3550"},{"key":"key\n\t\t\t\t20171011233331_BIB22","doi-asserted-by":"crossref","unstructured":"Ninomiya, Y. (1998) Reinnervation of cross-regenerated gustatory nerve fibers into amiloride-sensitive and amiloride-insensitive taste receptor cells. Proc. Natl Acad. Sci. USA, 95, 5347\u20135350.","DOI":"10.1073\/pnas.95.9.5347"},{"key":"key\n\t\t\t\t20171011233331_BIB23","doi-asserted-by":"crossref","unstructured":"Ninomiya, Y. and Funakoshi, M. (1988) Amiloride inhibition of responses of rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res., 451, 319\u201325.","DOI":"10.1016\/0006-8993(88)90777-9"},{"key":"key\n\t\t\t\t20171011233331_BIB24","doi-asserted-by":"crossref","unstructured":"Ninomiya, Y., Tanimukai, T., Yoshida, S. and Funakoshi, M. (1991) Gustatory neural responses in preweanling mice. Physiol. Behav., 49, 913\u2013918.","DOI":"10.1016\/0031-9384(91)90203-Z"},{"key":"key\n\t\t\t\t20171011233331_BIB25","doi-asserted-by":"crossref","unstructured":"Oakley, B., Lawton, A., Riddle, D.R. and Wu, L.H. (1993) Morphometric and immunocytochemical assessment of fungiform taste buds after interruption of the chorda-lingual nerve. Microsc. Res. Tech., 26, 187\u2013195.","DOI":"10.1002\/jemt.1070260302"},{"key":"key\n\t\t\t\t20171011233331_BIB26","doi-asserted-by":"crossref","unstructured":"Shigemura, N., Miura, H., Kusakabe, Y., Hino, A. and Ninomiya, Y. (2003) Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds. Arch. Histol. Cytol., 66, 253\u2013260.","DOI":"10.1679\/aohc.66.253"},{"key":"key\n\t\t\t\t20171011233331_BIB27","doi-asserted-by":"crossref","unstructured":"Shigemura, N., Ohta, R., Kusakabe, Y., Miura, H., Hino, A., Koyano, K., Nakashima, K. and Ninomiya, Y. (2004) Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology, 145, 839\u2013847.","DOI":"10.1210\/en.2003-0602"},{"key":"key\n\t\t\t\t20171011233331_BIB28","doi-asserted-by":"crossref","unstructured":"Simon, S.A., Holland, V.F., Benos, D.J. and Zampighi, G.A. (1993) Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. Microsc. Res. Tech., 26, 196\u2013208.","DOI":"10.1002\/jemt.1070260303"},{"key":"key\n\t\t\t\t20171011233331_BIB29","doi-asserted-by":"crossref","unstructured":"Smith, D.V., Klevitsky, R., Akeson, R.A. and Shipley, M.T. (1994) Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration. J. Comp. Neurol., 347, 187\u2013196.","DOI":"10.1002\/cne.903470204"},{"key":"key\n\t\t\t\t20171011233331_BIB30","doi-asserted-by":"crossref","unstructured":"Stevens, D.R., Seifert, R., Bufe, B., Muller, F., Kremmer, E., Gauss, R., Meyerhof, W., Kaupp, U.B. and Lindemann, B. (2001) Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature., 413, 631\u2013635.","DOI":"10.1038\/35098087"},{"key":"key\n\t\t\t\t20171011233331_BIB31","doi-asserted-by":"crossref","unstructured":"Stewart, R.E., Lasiter, P.S., Benos, D.J. and Hill, D.L. (1995) Immunohistochemical correlates of peripheral gustatory sensitivity to sodium and amiloride. Acta Anat., 153, 310\u2013319.","DOI":"10.1159\/000147740"},{"key":"key\n\t\t\t\t20171011233331_BIB32","doi-asserted-by":"crossref","unstructured":"Whitehead, M.C., Ganchrow, J.R., Ganchrow, D. and Yao, B. (1998) Neural cell adhesion molecule, neuron-specific enolase and calcitonin gene-related peptide immunoreactivity in hamster taste buds after chorda tympani\/lingual nerve denervation. Neuroscience, 83, 843\u2013856.","DOI":"10.1016\/S0306-4522(97)00442-9"},{"key":"key\n\t\t\t\t20171011233331_BIB33","doi-asserted-by":"crossref","unstructured":"Yasumatsu, K., Katsukawa, H., Sasamoto, K. and Ninomiya, Y. (2003) Recovery of amiloride-sensitive neural coding during regeneration of the gustatory nerve: behavioral\u2013neural correlation of salt taste discrimination. J. Neurosci., 23, 4362\u20134368.","DOI":"10.1523\/JNEUROSCI.23-10-04362.2003"},{"key":"key\n\t\t\t\t20171011233331_BIB34","doi-asserted-by":"crossref","unstructured":"Ye, Q., Heck, G.L. and DeSimone, J.A. (1991) The anion paradox in sodium taste reception: resolution by voltage-clamp studies. Science., 254, 724\u2013726.","DOI":"10.1126\/science.1948054"},{"key":"key\n\t\t\t\t20171011233331_BIB35","doi-asserted-by":"crossref","unstructured":"Ye, Q., Heck, G.L. and DeSimone, J.A. (1993) Voltage dependence of the rat chorda tympani response to Na+ salts: implications for the functional organization of taste receptor cells. J. Neurophysiol., 70, 167\u2013178.","DOI":"10.1152\/jn.1993.70.1.167"}],"container-title":["Chemical Senses"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/chemse\/article-pdf\/30\/6\/531\/1202621\/bji046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T05:36:04Z","timestamp":1551936964000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/chemse\/article\/30\/6\/531\/437946\/Expression-of-Amiloridesensitive-Epithelial-Sodium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,1]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,7,19]]},"published-print":{"date-parts":[[2005,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/chemse\/bji046","relation":{},"ISSN":["1464-3553","0379-864X"],"issn-type":[{"value":"1464-3553","type":"electronic"},{"value":"0379-864X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,7]]},"published":{"date-parts":[[2005,7,1]]}}}