{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:19:32Z","timestamp":1759033172467},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"DOI":"10.1093\/chemse\/bjj001","type":"journal-article","created":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T20:44:59Z","timestamp":1132778699000},"page":"9-26","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of the Validity of a Maximum Likelihood Adaptive Staircase Procedure for Measurement of Olfactory Detection Threshold in Mice"],"prefix":"10.1093","volume":"31","author":[{"given":"Amy C.","family":"Clevenger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"key\n\t\t\t\t20171011211740_BIB1","doi-asserted-by":"crossref","unstructured":"Apfelbach, R., Weiler, E., Asselbergs, W.F., Polak, E.H. and Slotnick, B. (1998) Selective and reversible reduction of odor sensitivity in the rat by concanavalin A.Physiol Behav., 65, 513\u2013516.","DOI":"10.1016\/S0031-9384(98)00197-8"},{"key":"key\n\t\t\t\t20171011211740_BIB2","doi-asserted-by":"crossref","unstructured":"Apter, A.J., Gent, J.F. and Frank, M.E. (1999) Fluctuating olfactory sensitivity and distorted odor perception in allergic rhinitis.Arch. Otolaryngol. Head Neck Surg., 125, 1005\u20131010.","DOI":"10.1001\/archotol.125.9.1005"},{"key":"key\n\t\t\t\t20171011211740_BIB3","doi-asserted-by":"crossref","unstructured":"Baker, H., Cummings, D.M., Munger, S.D., Margolis, J.W., Franzen, L., Reed, R.R. and Margolis, F.L. (1999) Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice.J. Neurosci., 19, 9313\u20139321.","DOI":"10.1523\/JNEUROSCI.19-21-09313.1999"},{"key":"key\n\t\t\t\t20171011211740_BIB4","doi-asserted-by":"crossref","unstructured":"Bodyak, N. and Slotnick, B. (1999) Performance of mice in an automated olfactometer: odor detection, discrimination and odor memory.Chem. Senses, 24, 637\u2013645.","DOI":"10.1093\/chemse\/24.6.637"},{"key":"key\n\t\t\t\t20171011211740_BIB5","doi-asserted-by":"crossref","unstructured":"Brunet, L.J., Gold, G.H. and Ngai, J. (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel.Neuron, 17, 681\u2013693.","DOI":"10.1016\/S0896-6273(00)80200-7"},{"key":"key\n\t\t\t\t20171011211740_BIB6","doi-asserted-by":"crossref","unstructured":"Buck, L.B. (2000) The molecular architecture of odor and pheromone sensing in mammals.Cell, 100, 611\u2013618.","DOI":"10.1016\/S0092-8674(00)80698-4"},{"key":"key\n\t\t\t\t20171011211740_BIB7","doi-asserted-by":"crossref","unstructured":"Cain, W.S., Gent, J.F., Catalanotto, F.A. and Goodspeed, R.B. (1983) Clinical evaluation of olfaction.Am. J. Otolaryngol., 4, 252\u2013256.","DOI":"10.1016\/S0196-0709(83)80068-4"},{"key":"key\n\t\t\t\t20171011211740_BIB8","doi-asserted-by":"crossref","unstructured":"Cometto-Muniz, J.E., Cain, W.S. and Abraham, M.H. (2003) Quantification of chemical vapors in chemosensory research.Chem. Senses, 28, 467\u2013477.","DOI":"10.1093\/chemse\/28.6.467"},{"key":"key\n\t\t\t\t20171011211740_BIB9","doi-asserted-by":"crossref","unstructured":"Harvey, L.O. Jr (1986) Efficient estimation of sensory thresholds.Behav. Res. Meth. Instrum. Comput., 18, 623\u2013632.","DOI":"10.3758\/BF03201438"},{"key":"key\n\t\t\t\t20171011211740_BIB10","doi-asserted-by":"crossref","unstructured":"Harvey, L.O. Jr (1997) Efficient estimation of sensory thresholds with ML-PEST.Spat. Vision, 11, 121\u2013128.","DOI":"10.1163\/156856897X00159"},{"key":"key\n\t\t\t\t20171011211740_BIB11","doi-asserted-by":"crossref","unstructured":"Krantz, D.H. (1969) Threshold theories of signal detection.Psychol. Rev., 76, 308\u2013324.","DOI":"10.1037\/h0027238"},{"key":"key\n\t\t\t\t20171011211740_BIB12","doi-asserted-by":"crossref","unstructured":"Lin, D.M., Wang, F., Lowe, G., Gold, G.H., Axel, R., Ngai, J. and Brunet, L. (2000) Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity.Neuron, 26, 69\u201380.","DOI":"10.1016\/S0896-6273(00)81139-3"},{"key":"key\n\t\t\t\t20171011211740_BIB13","doi-asserted-by":"crossref","unstructured":"Lin, W., Arellano, J., Slotnick, B. and Restrepo, D. (2004) Odors detected by mice deficient in olfactory cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system.J. Neurosci., 24, 3703\u20133710.","DOI":"10.1523\/JNEUROSCI.0188-04.2004"},{"key":"key\n\t\t\t\t20171011211740_BIB14","doi-asserted-by":"crossref","unstructured":"Linschoten, M.R., Harvey, L.O. Jr, Eller, P.M. and Jafek, B.W. (2001) Fast and accurate measurement of taste and smell thresholds using a maximum-likelihood adaptive staircase procedure.Percept. Psychophys., 63, 1330\u20131347.","DOI":"10.3758\/BF03194546"},{"key":"key\n\t\t\t\t20171011211740_BIB15","doi-asserted-by":"crossref","unstructured":"Lu, Z.L. and Dosher, B.A. (2004) Perceptual learning retunes the perceptual template in foveal orientation identification.J. Vision, 4, 44\u201356.","DOI":"10.1167\/4.1.5"},{"key":"key\n\t\t\t\t20171011211740_BIB16","doi-asserted-by":"crossref","unstructured":"Maloney, L.T. (1990) Confidence intervals for the parameters of psychometric functions.Percept. Psychophys., 47, 127\u2013134.","DOI":"10.3758\/BF03205977"},{"key":"key\n\t\t\t\t20171011211740_BIB17","doi-asserted-by":"crossref","unstructured":"McLean, J.H. and Harley, C.W. (2004) Olfactory learning in the rat pup: a model that may permit visualization of a mammalian memory trace.Neuroreport, 15, 1691\u20131697.","DOI":"10.1097\/01.wnr.0000134988.51310.c3"},{"key":"key\n\t\t\t\t20171011211740_BIB18","doi-asserted-by":"crossref","unstructured":"Pho, V., Butman, M.L. and Cherry, J.A. (2005) Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice.Behav. Brain Res., 161, 245\u2013253.","DOI":"10.1016\/j.bbr.2005.02.011"},{"key":"key\n\t\t\t\t20171011211740_BIB19","doi-asserted-by":"crossref","unstructured":"Pietras, R.J. and Moulton, D.G. (1974) Hormonal influences on odor detection in rats: changes associated with the estrous cycle, pseudopregnancy, ovariectomy, and administration of testosterone propionate.Physiol. Behav., 12, 475\u2013491.","DOI":"10.1016\/0031-9384(74)90125-5"},{"key":"key\n\t\t\t\t20171011211740_BIB20","unstructured":"Press, W.H., Teukolsky, S.A., Vettering, W.T. and Flannery, B.P. (1992) Numerical Recipes in C. Cambridge University Press, Cambridge, UK."},{"key":"key\n\t\t\t\t20171011211740_BIB21","doi-asserted-by":"crossref","unstructured":"Salcedo, E., Zhang, C., Kronberg, E. and Restrepo, D. (2005) Analysis of training-induced changes in ethyl acetate odor maps using a new computational tool to map the glomerular layer of the olfactory bulb.Chem. Senses, 30, 615\u2013626.","DOI":"10.1093\/chemse\/bji055"},{"key":"key\n\t\t\t\t20171011211740_BIB22","doi-asserted-by":"crossref","unstructured":"Slotnick, B.M., Bell, G.A., Panhuber, H. and Laing, D.G. (1997) Detection and discrimination of propionic acid after removal of its 2-DG identified major focus in the olfactory bulb: a psychophysical analysis.Brain Res., 762, 89\u201396.","DOI":"10.1016\/S0006-8993(97)00357-0"},{"key":"key\n\t\t\t\t20171011211740_BIB23","doi-asserted-by":"crossref","unstructured":"Slotnick, B.M. and Schoonover, F.W. (1993) Olfactory sensitivity of rats with transection of the lateral olfactory tract.Brain Res., 616, 132\u2013137.","DOI":"10.1016\/0006-8993(93)90201-W"},{"key":"key\n\t\t\t\t20171011211740_BIB24","doi-asserted-by":"crossref","unstructured":"Terutwein, B. and Strasburger, H. (1999) Fitting the psychometric function.Percept. Psychophys., 61, 87\u2013106.","DOI":"10.3758\/BF03211951"},{"key":"key\n\t\t\t\t20171011211740_BIB25","doi-asserted-by":"crossref","unstructured":"Vedin, V., Slotnick, B. and Berghard, A. (2004) Zonal ablation of the olfactory sensory neuroepithelium of the mouse: effects on odorant detection.Eur. J. Neurosci., 20, 1858\u20131864.","DOI":"10.1111\/j.1460-9568.2004.03634.x"},{"key":"key\n\t\t\t\t20171011211740_BIB26","doi-asserted-by":"crossref","unstructured":"Watson, A.B. and Pelli, D.G. (1983) QUEST: a Bayesian adaptive psychometric method.Percept. Psychophys., 33, 113\u2013120.","DOI":"10.3758\/BF03202828"},{"key":"key\n\t\t\t\t20171011211740_BIB27","doi-asserted-by":"crossref","unstructured":"Wetherhill, G.B. and Levitt, H. (1965) Sequential estimation of points on a psychometric function.Br. J. Math. Stat. Psychol., 18, 1\u201310.","DOI":"10.1111\/j.2044-8317.1965.tb00689.x"},{"key":"key\n\t\t\t\t20171011211740_BIB28","doi-asserted-by":"crossref","unstructured":"Wichmann, F.A. and Hill, N.J. (2001) The psychometric function: I. Fitting, sampling, and goodness of fit.Percept. Psychophys., 63, 1293\u20131313.","DOI":"10.3758\/BF03194544"},{"key":"key\n\t\t\t\t20171011211740_BIB29","doi-asserted-by":"crossref","unstructured":"Wilson, D.A. and Stevenson, R.J. (2003) Olfactory perceptual learning: the critical role of memory in odor discrimination.Neurosci. Biobehav. Rev., 27, 307\u2013328.","DOI":"10.1016\/S0149-7634(03)00050-2"},{"key":"key\n\t\t\t\t20171011211740_BIB30","doi-asserted-by":"crossref","unstructured":"Witte, R.S. and Kipke, D.R. (2005) Enhanced contrast sensitivity in auditory cortex as cats learn to discriminate sound frequencies.Brain Res. Cogn. Brain Res., 23, 171\u2013184.","DOI":"10.1016\/j.cogbrainres.2004.10.018"},{"key":"key\n\t\t\t\t20171011211740_BIB31","doi-asserted-by":"crossref","unstructured":"Xu, F.Q., Greer, C.A. and Shepherd, G.M. (2000) Odor maps in the olfactory bulb.J. Comp. Neurol., 422, 489\u2013495.","DOI":"10.1002\/1096-9861(20000710)422:4<489::AID-CNE1>3.0.CO;2-#"},{"key":"key\n\t\t\t\t20171011211740_BIB32","doi-asserted-by":"crossref","unstructured":"Youngentob, S.L. and Margolis, F.L. (1999) OMP gene deletion causes an elevation in behavioral threshold sensitivity.Neuroreport, 10, 15\u201319.","DOI":"10.1097\/00001756-199901180-00003"},{"key":"key\n\t\t\t\t20171011211740_BIB33","doi-asserted-by":"crossref","unstructured":"Youngentob, S.L., Pyrski, M.M. and Margolis, F.L. (2004) Adenoviral vector-mediated rescue of the OMP-null behavioral phenotype: enhancement of odorant threshold sensitivity.Behav. Neurosci., 118, 636\u2013642.","DOI":"10.1037\/0735-7044.118.3.636"},{"key":"key\n\t\t\t\t20171011211740_BIB34","doi-asserted-by":"crossref","unstructured":"Youngentob, S.L., Schwob, J.E., Sheehe, P.R. and Youngentob, L.M. (1997) Odorant threshold following methyl bromide-induced lesions of the olfactory epithelium.Physiol. Behav., 62, 1241\u20131252.","DOI":"10.1016\/S0031-9384(97)00301-6"},{"key":"key\n\t\t\t\t20171011211740_BIB35","doi-asserted-by":"crossref","unstructured":"Zheng, C., Feinstein, P., Bozza, T., Rodriguez, I. and Mombaerts, P. (2000) Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit.Neuron, 26, 81\u201391.","DOI":"10.1016\/S0896-6273(00)81140-X"}],"container-title":["Chemical Senses"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/chemse\/article-pdf\/31\/1\/9\/1046523\/bjj001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T13:03:28Z","timestamp":1554642208000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/chemse\/article\/31\/1\/9\/366753\/Evaluation-of-the-Validity-of-a-Maximum-Likelihood"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,23]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,11,23]]},"published-print":{"date-parts":[[2006,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/chemse\/bjj001","relation":{},"ISSN":["1464-3553","0379-864X"],"issn-type":[{"value":"1464-3553","type":"electronic"},{"value":"0379-864X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,1]]},"published":{"date-parts":[[2005,11,23]]}}}