{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:53:58Z","timestamp":1773406438491,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1093\/chemse\/bju020","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T01:17:01Z","timestamp":1400635021000},"page":"515-528","source":"Crossref","is-referenced-by-count":40,"title":["Salty Taste Deficits in CALHM1 Knockout Mice"],"prefix":"10.1093","volume":"39","author":[{"given":"Michael G.","family":"Tordoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary T.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany R.","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnelle","family":"Downing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Marambaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Kevin","family":"Foskett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Dana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"McCaughey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"issue":"6","key":"key\n\t\t\t\t20170522211031_CIT0001","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","author":"Bachmanov","year":"2002","journal-title":"Behav Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0002","doi-asserted-by":"crossref","first-page":"R1027","DOI":"10.1152\/ajpregu.00843.2009","article-title":"Learning-based recovery from perceptual impairment in salt discrimination after permanently altered peripheral gustatory input","volume":"299","author":"Blonde","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(85)90212-4","article-title":"Inhibition by amiloride of chorda tympani responses evoked by monovalent salts","volume":"334","author":"Brand","year":"1985","journal-title":"Brain Res"},{"issue":"7286","key":"key\n\t\t\t\t20170522211031_CIT0004","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature08783","article-title":"The cells and peripheral representation of sodium taste in mice","volume":"464","author":"Chandrashekar","year":"2010","journal-title":"Nature"},{"issue":"1","key":"key\n\t\t\t\t20170522211031_CIT0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0031-9384(77)90178-0","article-title":"Taste responses of the chorda tympani nerve in the mouse","volume":"19","author":"Cheal","year":"1977","journal-title":"Physiol Behav"},{"key":"key\n\t\t\t\t20170522211031_CIT0006","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neures.2013.02.003","article-title":"A\/J and C57BL\/6J mice differ in chorda tympani responses to NaCl","volume":"75","author":"Cherukuri","year":"2013","journal-title":"Neurosci Res"},{"issue":"5","key":"key\n\t\t\t\t20170522211031_CIT0007","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.physbeh.2010.12.024","article-title":"Comparison of differences between PWD\/PhJ and C57BL\/6J mice in calcium solution preferences and chorda tympani nerve responses","volume":"102","author":"Cherukuri","year":"2011","journal-title":"Physiol Behav"},{"issue":"6","key":"key\n\t\t\t\t20170522211031_CIT0008","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1037\/0735-7044.118.6.1409","article-title":"Effects of selective lingual gustatory deafferentation on suprathreshold taste intensity discrimination of NaCl in rats","volume":"118","author":"Colbert","year":"2004","journal-title":"Behav Neurosci"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0009","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0006-8993(77)90162-7","article-title":"Changes in gustatory nerve discharges with sodium deficiency: a single unit analysis","volume":"121","author":"Contreras","year":"1977","journal-title":"Brain Res"},{"issue":"3","key":"key\n\t\t\t\t20170522211031_CIT0010","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/chemse\/bjj027","article-title":"Trpm5 null mice respond to bitter, sweet, and umami compounds","volume":"31","author":"Damak","year":"2006","journal-title":"Chem Senses"},{"issue":"5634","key":"key\n\t\t\t\t20170522211031_CIT0011","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1087155","article-title":"Detection of sweet and umami taste in the absence of taste receptor T1r3","volume":"301","author":"Damak","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522211031_CIT0012","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1152\/ajpregu.1985.249.1.R52","article-title":"Analysis of amiloride inhibition of chorda tympani raste response of rat to NaCl","volume":"249","author":"DeSimone","year":"1985","journal-title":"Am J Physiol Regul Integ Comp Physiol"},{"issue":"7","key":"key\n\t\t\t\t20170522211031_CIT0013","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/chemse\/bji053","article-title":"PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands","volume":"30","author":"Dotson","year":"2005","journal-title":"Chem Senses"},{"issue":"7","key":"key\n\t\t\t\t20170522211031_CIT0014","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2008.05.048","article-title":"A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer\u2019s disease risk","volume":"133","author":"Dreses-Werringloer","year":"2008","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522211031_CIT0500","first-page":"1199","article-title":"CALHM1 controls the Ca2+-dependent MEK, ERK, RSK and MSK signaling cascade in neurons","volume-title":"J Cell Sci","author":"Dreses-Werringloer","year":"2013"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0031-9384(99)00071-2","article-title":"Chorda tympani responses in two inbred strains of mice with different taste preferences","volume":"67","author":"Frank","year":"1999","journal-title":"Physiol Behav"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0016","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0006-8993(91)91325-U","article-title":"The effect of amiloride on taste-evoked activity in the nucleus tractus solitarius of the rat","volume":"550","author":"Giza","year":"1991","journal-title":"Brain Res"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0017","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/chemse\/bji025","article-title":"Contribution of alpha-gustducin to taste-guided licking responses of mice","volume":"30","author":"Glendinning","year":"2005","journal-title":"Chem Senses"},{"issue":"5","key":"key\n\t\t\t\t20170522211031_CIT0018","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/chemse\/27.5.461","article-title":"A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function","volume":"27","author":"Glendinning","year":"2002","journal-title":"Chem Senses"},{"issue":"3","key":"key\n\t\t\t\t20170522211031_CIT0019","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1152\/jn.00892.2007","article-title":"Evidence for two populations of bitter responsive taste cells in mice","volume":"99","author":"Hacker","year":"2008","journal-title":"J Neurophysiol"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/chemse\/22.2.133","article-title":"Different characteristics of gustatory responses between the greater superficial petrosal and chorda tympani nerves in the rat","volume":"22","author":"Harada","year":"1997","journal-title":"Chem Senses"},{"issue":"35","key":"key\n\t\t\t\t20170522211031_CIT0021","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1523\/JNEUROSCI.2441-04.2004","article-title":"Umami taste responses are mediated by alpha-transducin and alpha-gustducin","volume":"24","author":"He","year":"2004","journal-title":"J Neurosci"},{"issue":"4634","key":"key\n\t\t\t\t20170522211031_CIT0022","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.6691151","article-title":"Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway","volume":"223","author":"Heck","year":"1984","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522211031_CIT0023","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1146\/annurev.physiol.61.1.873","article-title":"Cellular mechanisms of taste transduction","volume":"61","author":"Herness","year":"1999","journal-title":"Annu Rev Physiol"},{"key":"key\n\t\t\t\t20170522211031_CIT0024","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1111\/j.1753-4887.2004.tb00101.x","article-title":"Neural plasticity in the gustatory system","volume":"62","author":"Hill","year":"2004","journal-title":"Nutr Rev"},{"issue":"51","key":"key\n\t\t\t\t20170522211031_CIT0025","doi-asserted-by":"crossref","first-page":"37225","DOI":"10.1074\/jbc.M705641200","article-title":"Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor","volume":"282","author":"Hisatsune","year":"2007","journal-title":"J Biol Chem"},{"issue":"44","key":"key\n\t\t\t\t20170522211031_CIT0026","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.1523\/JNEUROSCI.2351-09.2009","article-title":"Autocrine and paracrine roles for ATP and serotonin in mouse taste buds","volume":"29","author":"Huang","year":"2009","journal-title":"J Neurosci"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0027","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/chemse\/bjp001","article-title":"A high-throughput method to measure NaCl and acid taste thresholds in mice","volume":"34","author":"Ishiwatari","year":"2009","journal-title":"Chem Senses"},{"issue":"6","key":"key\n\t\t\t\t20170522211031_CIT0028","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/chemse\/bjr135","article-title":"NaCl taste thresholds in 13 inbred mouse strains","volume":"37","author":"Ishiwatari","year":"2012","journal-title":"Chem Senses"},{"key":"key\n\t\t\t\t20170522211031_CIT0029","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fncel.2013.00264","article-title":"A taste for ATP: neurotransmission in taste buds","volume":"7","author":"Kinnamon","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"key\n\t\t\t\t20170522211031_CIT0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.2004.065656","article-title":"The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant","volume":"558","author":"Lyall","year":"2004","journal-title":"J Physiol"},{"issue":"28","key":"key\n\t\t\t\t20170522211031_CIT0031","doi-asserted-by":"crossref","first-page":"E1963","DOI":"10.1073\/pnas.1204023109","article-title":"Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability","volume":"109","author":"Ma","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"key\n\t\t\t\t20170522211031_CIT0032","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0149-7634(97)00067-5","article-title":"The taste of sodium","volume":"22","author":"McCaughey","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0033","doi-asserted-by":"crossref","first-page":"R960","DOI":"10.1152\/ajpregu.91018.2008","article-title":"Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity","volume":"296","author":"Ohkuri","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"key\n\t\t\t\t20170522211031_CIT0034","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/chemse\/bjj061","article-title":"Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129 substrains of mice, 129P3\/J and 129X1\/SvJ","volume":"31","author":"Ohkuri","year":"2006","journal-title":"Chem Senses"},{"issue":"7438","key":"key\n\t\t\t\t20170522211031_CIT0035","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature11905","article-title":"High salt recruits aversive taste pathways","volume":"494","author":"Oka","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522211031_CIT0036","first-page":"p. 75","article-title":"Taste psychophysics","volume-title":"Handbook of sensory physiology; Chemical Senses Vol IV, Section 2","author":"Pfaffman","year":"1971"},{"issue":"1","key":"key\n\t\t\t\t20170522211031_CIT0037","doi-asserted-by":"crossref","first-page":"G106","DOI":"10.1152\/ajpgi.00053.2013","article-title":"TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response","volume":"305","author":"Ren","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"key\n\t\t\t\t20170522211031_CIT0038","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semcdb.2012.12.002","article-title":"Taste buds as peripheral chemosensory processors","volume":"24","author":"Roper","year":"2013","journal-title":"Semin Cell Dev Biol"},{"issue":"7","key":"key\n\t\t\t\t20170522211031_CIT0039","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/chemse\/bjg049","article-title":"Behavioral evidence for a role of alpha-gustducin in glutamate taste","volume":"28","author":"Ruiz","year":"2003","journal-title":"Chem Senses"},{"issue":"9","key":"key\n\t\t\t\t20170522211031_CIT0040","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1074\/jbc.M112.409789","article-title":"Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins","volume":"288","author":"Siebert","year":"2013","journal-title":"J Biol Chem"},{"issue":"2","key":"key\n\t\t\t\t20170522211031_CIT0041","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1037\/h0028228","article-title":"Role of oropharyngeal factors in LiCl aversion","volume":"69","author":"Smith","year":"1969","journal-title":"J Comp Physiol Psychol"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0042","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1037\/0735-7044.112.4.991","article-title":"Taste responses in the greater superficial petrosal nerve: substantial sodium salt and amiloride sensitivities demonstrated in two rat strains","volume":"112","author":"Sollars","year":"1998","journal-title":"Behav Neurosci"},{"issue":"2-3","key":"key\n\t\t\t\t20170522211031_CIT0043","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0300-9629(94)90085-X","article-title":"Neural responses of the glossopharyngeal nerve to several bitter stimuli in mice","volume":"108","author":"Tanimura","year":"1994","journal-title":"Comp Biochem Physiol Comp Physiol"},{"issue":"12","key":"key\n\t\t\t\t20170522211031_CIT0044","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/bies.201300077","article-title":"How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel","volume":"35","author":"Taruno","year":"2013","journal-title":"Bioessays"},{"issue":"7440","key":"key\n\t\t\t\t20170522211031_CIT0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature11906","article-title":"CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes","volume":"495","author":"Taruno","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522211031_CIT0046","author":"Tordoff","year":"2001"},{"key":"key\n\t\t\t\t20170522211031_CIT0047","author":"Tordoff","year":"2001"},{"issue":"4","key":"key\n\t\t\t\t20170522211031_CIT0048","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/chemse\/28.4.315","article-title":"Mouse taste preference tests: why only two bottles?","volume":"28","author":"Tordoff","year":"2003","journal-title":"Chem Senses"},{"issue":"5","key":"key\n\t\t\t\t20170522211031_CIT0049","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.physbeh.2007.03.025","article-title":"Forty mouse strain survey of water and sodium intake","volume":"91","author":"Tordoff","year":"2007","journal-title":"Physiol Behav"},{"issue":"6585","key":"key\n\t\t\t\t20170522211031_CIT0050","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/381796a0","article-title":"Transduction of bitter and sweet taste by gustducin","volume":"381","author":"Wong","year":"1996","journal-title":"Nature"},{"issue":"6","key":"key\n\t\t\t\t20170522211031_CIT0051","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s13238-012-2932-6","article-title":"Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression","volume":"3","author":"Wu","year":"2012","journal-title":"Protein Cell"},{"issue":"3","key":"key\n\t\t\t\t20170522211031_CIT0052","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/chemse\/19.3.209","article-title":"Some critical factors involved in formation of conditioned taste aversion to sodium chloride in rats","volume":"19","author":"Yamamoto","year":"1994","journal-title":"Chem Senses"},{"issue":"3","key":"key\n\t\t\t\t20170522211031_CIT0053","doi-asserted-by":"crossref","first-page":"747S","DOI":"10.3945\/ajcn.2009.27462J","article-title":"Multiple receptors underlie glutamate taste responses in mice","volume":"90","author":"Yasumatsu","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t20170522211031_CIT0054","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1113\/jphysiol.2011.211920","article-title":"Umami taste in mice uses multiple receptors and transduction pathways","volume":"590","author":"Yasumatsu","year":"2012","journal-title":"J Physiol"},{"issue":"3","key":"key\n\t\t\t\t20170522211031_CIT0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(03)00071-0","article-title":"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways","volume":"112","author":"Zhang","year":"2003","journal-title":"Cell"}],"container-title":["Chemical Senses"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T13:36:40Z","timestamp":1565444200000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/chemse\/article-lookup\/doi\/10.1093\/chemse\/bju020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,5,20]]},"published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/chemse\/bju020","relation":{},"ISSN":["0379-864X","1464-3553"],"issn-type":[{"value":"0379-864X","type":"print"},{"value":"1464-3553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,20]]}}}