{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:59:42Z","timestamp":1793192382429,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6D0161-3"],"award-info":[{"award-number":["CORPG6D0161-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6D0251-3"],"award-info":[{"award-number":["CORPG6D0251-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG6G0451"],"award-info":[{"award-number":["CMRPG6G0451"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored the effects of various parameters on taste impairments (TIs) in head-and-neck (H&amp;N) cancer patients receiving intensity-modulated radiotherapy (IMRT). From January 2014 to September 2017, 88 H&amp;N cancer patients subjected to curative or postoperative IMRT were enrolled in this prospective study. All patients underwent at least 1 year of follow-up after IMRT. Quality-of-life assessments in terms of patient-reported gustatory function were measured using the taste-related questions of the European Organization for Research and Treatment of Cancer H&amp;N35 questionnaires. At a median follow-up time of 27 months, 27 of 88 patients (30.7%) reported long-term TIs. In multivariate analyses, glossectomy most significantly predicted TIs (P = 0.04). The percentage of TIs (61.5%) was significantly (P = 0.03) higher in patients who underwent partial or total glossectomy than in patients who did not undergo surgery (28.0%) and those who underwent radical surgery without glossectomy (20.0%). When we excluded surgical patients from analyses, the mean radiation dose to the oral cavity was of borderline significance in terms of TI prediction (P = 0.05). Only 10.5% of patients suffered from TIs when the mean radiation dose was &lt;5000 cGy compared with 38.7% when the mean dose was \u22655000 cGy. In conclusion, glossectomy is the major cause of long-term TIs in H&amp;N cancer patients receiving IMRT. In patients who do not undergo glossectomy, reduction of the mean radiation dose to the oral cavity may reduce TIs after IMRT.<\/jats:p>","DOI":"10.1093\/chemse\/bjz018","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T11:21:31Z","timestamp":1554204091000},"page":"319-326","source":"Crossref","is-referenced-by-count":29,"title":["Long-Term Taste Impairment after Intensity-Modulated Radiotherapy to Treat Head-and-Neck Cancer: Correlations with Glossectomy and the Mean Radiation Dose to the Oral Cavity"],"prefix":"10.1093","volume":"44","author":[{"given":"Wen-Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan"},{"name":"College of Medicine, Chang Gung University, Tao-yuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shao","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Te","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hsuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Pin","family":"Lee","sequence":"additional","affiliation":[{"name":"Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-0388","authenticated-orcid":false,"given":"Miao-Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan"},{"name":"College of Medicine, Chang Gung University, Tao-yuan, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"2019071702560178300_CIT0001","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0714.2012.01200.x","article-title":"Taste alteration and impact on quality of life after head and neck radiotherapy","volume":"42","author":"Baharvand","year":"2013","journal-title":"J Oral Pathol Med"},{"key":"2019071702560178300_CIT0002","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1242\/dev.120394","article-title":"Progress and renewal in gustation: new insights into taste bud development","volume":"142","author":"Barlow","year":"2015","journal-title":"Development"},{"key":"2019071702560178300_CIT0003","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3109\/0284186X.2014.895035","article-title":"Self-reported taste and smell alterations in patients under investigation for lung cancer","volume":"53","author":"Belqaid","year":"2014","journal-title":"Acta Oncol"},{"key":"2019071702560178300_CIT0004","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00520-007-0319-7","article-title":"Self-reported taste and smell changes during cancer chemotherapy","volume":"16","author":"Bernhardson","year":"2008","journal-title":"Support Care Cancer"},{"key":"2019071702560178300_CIT0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","article-title":"CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines","volume":"117","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"key":"2019071702560178300_CIT0006","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/hed.20045","article-title":"Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management","volume":"26","author":"Chambers","year":"2004","journal-title":"Head Neck"},{"key":"2019071702560178300_CIT0007","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.oraloncology.2008.07.002","article-title":"Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity","volume":"45","author":"Chen","year":"2009","journal-title":"Oral Oncol"},{"key":"2019071702560178300_CIT0008","first-page":"2407","article-title":"Nutritional consequences of radiotherapy","volume":"37","author":"Donaldson","year":"1977","journal-title":"Cancer Res"},{"key":"2019071702560178300_CIT0009","first-page":"141","volume-title":"Taste and cancer. 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