{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:32:15Z","timestamp":1768084335886,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the presented work, a three-way analysis of ultra-performance liquid chromatography-photodiode array (UPLC-PDA) dataset was performed by parallel factor analysis (PARAFAC) for quantitatively resolving a ternary mixture containing paracetamol and methocarbamol with indapamide selected as an internal standard in their co-eluted chromatographic conditions. Paracetamol and methocarbamol were quantified in the working range between 3\u201324 and 5\u201350\u00a0\u03bcg\/mL by applying PARAFAC decomposition to UPLC-PDA data array obtained under unresolved chromatographic peak conditions. To compare the experimental results provided by co-eluted UPLC-PARAFAC method, an ordinary UPLC method was developed ensuring proper separation of the peaks. The performance of both PARAFAC and ordinary UPLC methods were assessed by quantifying independent test samples, intra- and inter-day samples and spiked samples of pharmaceutical preparations. Then, both methods were applied for quantitative estimation of the related drugs in a commercial pharmaceutical preparation. In this study, PARAFAC method was proved to be a very powerful alternative for the quality control of pharmaceutical preparations containing paracetamol and methocarbamol even in their co-eluted chromatograms with high precision and accuracy in a short chromatographic runtime of 1.2\u00a0min.<\/jats:p>","DOI":"10.1093\/chromsci\/bmaa119","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T12:24:28Z","timestamp":1610540668000},"page":"361-370","source":"Crossref","is-referenced-by-count":10,"title":["A New Application of PARAFAC Model to UPLC Dataset for the Quantitative Resolution of a Tri-Component Drug Mixture"],"prefix":"10.1093","volume":"59","author":[{"given":"Remziye","family":"G\u00fczel","sequence":"first","affiliation":[{"name":"Department of Science, Dicle University, Sur, Diyarbak\u0131r 21280, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra Ceren","family":"Ertekin","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Ankara University, Degol St. No:4, Ankara 06560, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-1441","authenticated-orcid":false,"given":"Erdal","family":"Din\u00e7","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Ankara University, Degol St. No:4, Ankara 06560, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"issue":"4","key":"2021031908531755100_ref1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1163\/156856003322699573","article-title":"Mechanisms of action of paracetamol and related analgesics","volume":"11","author":"Graham","year":"2003","journal-title":"Inflammopharmacology"},{"issue":"2","key":"2021031908531755100_ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1592\/phco.28.2.207","article-title":"Skeletal muscle relaxants","volume":"28","author":"See","year":"2008","journal-title":"Pharmacotherapy"},{"issue":"1","key":"2021031908531755100_ref3","first-page":"1","article-title":"Feyyaz; simultaneous spectrophotometric determination of paracetamol and methocarbamol in a pharmaceutical preparation using chemometric techniques","volume":"1","author":"Palab\u0131y\u0131k","year":"2004","journal-title":"Turkish Journal of Pharmaceutical Sciences"},{"key":"2021031908531755100_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2015.01.017","article-title":"Smart manipulation of ratio spectra for resolving a pharmaceutical mixture of methocarbamol and paracetamol","volume":"141","author":"Essam","year":"2015","journal-title":"Spectrochimica Acta - Part A: molecular and Biomolecular Spectroscopy"},{"issue":"11","key":"2021031908531755100_ref5","first-page":"710","article-title":"Reverse phase high performance liquid chromatographic determination of ibuprofen, paracetamol and methocarbamol in tablets","volume":"36","author":"Zarapkar","year":"1999","journal-title":"Indian Drugs"},{"issue":"8","key":"2021031908531755100_ref6","first-page":"386","article-title":"Simultaneous estimation of paracetamol, methocarbamol and ibuprofen by reversed phase HPLC method","volume":"37","author":"Vasudevan","year":"2000","journal-title":"Indian Drugs"},{"issue":"15","key":"2021031908531755100_ref7","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1080\/10826076.2011.629390","article-title":"Selective reversed phase high performance liquid chromatography for the simultaneous determination of some pharmaceutical binary mixtures containing nsaids","volume":"35","author":"El-Kommos","year":"2012","journal-title":"Journal of Liquid Chromatography and Related Technologies"},{"issue":"2","key":"2021031908531755100_ref8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1039\/C2AY26085A","article-title":"Validated stability indicating RP-HPLC method for determination of paracetamol, methocarbamol and their related substances","volume":"5","author":"Abdelaleem","year":"2013","journal-title":"Analytical Methods"},{"issue":"7","key":"2021031908531755100_ref9","first-page":"363","article-title":"Simultaneous determination of paracetamol and methocarbamol in human plasma by HPLC using UV detection with time programming: application to pharmacokinetic study","volume":"64","author":"Helmy","year":"2014","journal-title":"Drug Research"},{"key":"2021031908531755100_ref10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.microc.2019.04.079","article-title":"A micellar HPLC method for simultaneous determination of methocarbamol in three different tablets using single run; 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