{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:13:05Z","timestamp":1747739585757},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to establish an ion chromatography for the simultaneous determination of nitrite and azide ions in valsartan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Dionex IonpacAG18 (4\u00a0\u00d7\u00a050\u00a0mm2) and Dionex IonpacAS18 (4\u00a0\u00d7\u00a0250\u00a0mm2) were used as the 2D guard column and analytical column, respectively. Dionex AMGTMC18 (4\u00a0\u00d7\u00a030\u00a0mm2) was used as a 1D pre-separation column and Dionex UTAC-ULP1 as the concentration column. KOH solution generated by an online eluent generator (EG) was used as the 2D mobile phase, and gradient elution was performed at 1\u00a0mL\/min. Water and acetonitrile were used as 1D mobile phase, and gradient elution was performed at 0.5\u00a0mL\/min. Suppressed conductivity detector (suppressor, ASRS 300 4\u00a0mm) was used for detection. The column temperature was 30\u00b0C, while that of the detector was 35\u00b0C.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This method showed satisfactory reproducibility and recovery. The linear range and the correlation coefficient for both nitrite and azide ions were 0.01\u20130.2\u00a0mg\/L and 0.9998, respectively. However, the recovery rate was 85\u2013115% for nitrite and 90\u2013110% for azide ions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This method was suitable for the simultaneous determination of nitrite and azide ions in valsartan and other sartan drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/chromsci\/bmaa131","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T11:30:42Z","timestamp":1608204642000},"page":"758-761","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous Determination of Nitrite and Azide Ions in Valsartan"],"prefix":"10.1093","volume":"59","author":[{"given":"Xueyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianjiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"issue":"11","key":"2021081906512045300_ref1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1517\/14656566.2.11.1795","article-title":"Angiotensin II receptor blockers for the treatment of hypertension","volume":"2","author":"See","year":"2001","journal-title":"Expert Opin Pharmacother"},{"issue":"9","key":"2021081906512045300_ref2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2217\/cer-2019-0014","article-title":"Evolution of functional class, biochemical and echocardiographic parameters and clinical outcomes after sacubitril\/valsartan initiation in daily 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