{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:28:49Z","timestamp":1790735329391,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Determination of penicillin residues in different industrial effluents including wastewater and air samples is important to prevent exposure to residual amounts of penicillin and the development of antibiotic resistance. A green high performance liquid chromatography (HPLC) method coupled with diode array detection has been developed and validated for multiplex determination of nine penicillin antibiotics in the industrial air dust and wastewater environmental samples of penicillin facility in addition to the monitoring of facility surface cleaning. Separation was performed on C18 column with gradient elution of methanol and phosphate buffer (pH 4) at a flow rate of 1.5 mL min-1 and ultra violet (UV) detection at 220\u00a0nm. Low limits of detection were achieved (0.1\u20130.3 \u03bcg mL-1) indicating good sensitivity of the proposed. The method was applied for ensuring the efficiency of cleaning validation after worst-case selection. Recovery studies of the studied penicillins from fortified stainless steel and polycarbonate surfaces and swabs were between 91.91 and 100.22% with relative standard deviation 0.11\u20131.79%. The presence of any of the studied penicillins in wastewater samples from penicillin plant drainage was checked. Also, total air dust concentration (mg m\u20133) and % of penicillin active material residues in air dust were calculated from the area of the exposed group in suspension, tablet and vial production lines. The proposed method can be recommended for routine analysis of air and wastewater environmental samples for the detection of penicillin antibiotics at low levels as well as monitoring of facility surface cleaning with high accuracy and precision.<\/jats:p>","DOI":"10.1093\/chromsci\/bmac036","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:10:45Z","timestamp":1649920245000},"page":"644-655","source":"Crossref","is-referenced-by-count":5,"title":["Green Multiplex Chromatographic Determination of Nine Penicillin Antibiotics Residues in Industrial Air Dust and Wastewater Environmental Samples"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-862X","authenticated-orcid":false,"given":"Eman I","family":"El-Kimary","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"},{"name":"Alexandria University , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A","family":"Korany","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"},{"name":"Alexandria University , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"},{"name":"Alexandria University , Faculty of Pharmacy, , El-Messalah, Alexandria 21521, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed G","family":"Basuny","sequence":"additional","affiliation":[{"name":"Pharco Pharmaceutical Industrial Company, Quality Control Department , Alexandria 23511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"2023082102090555500_ref1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3949\/ccjm.82a.14111","article-title":"Penicillin allergy: a practical guide for clinicians","volume":"82","author":"Gonzalez-Estrada","year":"2015","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"2023082102090555500_ref2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/10773525.2016.1201238","article-title":"Penicillin dust exposure and penicillin resistance among pharmaceutical workers in Tehran, Iran","volume":"22","author":"Farshad","year":"2016","journal-title":"International Journal of Occupational and Environmental Health"},{"key":"2023082102090555500_ref3","author":"European Commision, Directorate General for Health and Food Safety","year":"2015"},{"key":"2023082102090555500_ref4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1039\/C7NP00019G","article-title":"Opportunities for natural products in 21st century antibiotic discovery","volume":"34","author":"Wright","year":"2017","journal-title":"Natural Product Reports"},{"key":"2023082102090555500_ref5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1590\/S1516-89132006000200007","article-title":"Determination of beta-lactam residues in milk by high performance liquid chromatography","volume":"49","author":"Brito","year":"2006","journal-title":"Brazilian Archives of Biology and Technology"},{"key":"2023082102090555500_ref6","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jchromb.2011.05.021","article-title":"Simultaneous analysis of amoxicillin and sulbactam in human plasma by HPLC-DAD for assessment of bioequivalence","volume":"879","author":"Pei","year":"2011","journal-title":"Journal of Chromatography. 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