{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:21:23Z","timestamp":1781104883128,"version":"3.54.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"agency or organization"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u00a0<\/jats:title>\n                  <jats:p>Ophthalmic pharmaceutical preparation containing antazoline (ANT) and tetryzoline (TET) is prescribed widely as an over the counter medication for allergic conjunctivitis treatment. Development of a selective, simple and environmentally friendly thin-layer chromatographic method established to determine both ANT and TET in their pure forms, pharmaceutical formulation and spiked aqueous humor samples. By using silica gel plates and means of a developing system consists of ethyl acetate:ethanol (5:5, by volume), the studied drugs separation was achieved, and scanning was carried out at 220.0\u00a0nm for the separated bands with a 0.2\u201318.0\u00a0\u03bcg\/band concentration range for each of ANT and TET. Standard addition technique application was carried out to determine the proposed method validity. Statistical comparison was made between the proposed method and the official methods ANT and TET showing no significant difference concerning accuracy and precision. Furthermore, greenness profile assessment was accomplished by means of four metric tools, namely, analytical greenness, green analytical procedure index, analytical eco-scale and national environmental method index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>\u00a0<\/jats:title>\n                  <jats:p>Highlights<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/chromsci\/bmad042","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:54:15Z","timestamp":1686790455000},"page":"807-814","source":"Crossref","is-referenced-by-count":10,"title":["Green TLC-Densitometric Method for Simultaneous Determination of Antazoline and Tetryzoline: Application to Pharmaceutical Formulation and Rabbit Aqueous Humor"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-9843","authenticated-orcid":false,"given":"Ola G","family":"Hussein","sequence":"first","affiliation":[{"name":"Future University in Egypt Pharmaceutical Chemistry Department, Faculty of Pharmacy, , End of 90th St., Fifth Settlement, New Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Rostom","sequence":"additional","affiliation":[{"name":"Cairo University Analytical Chemistry Department, Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelkawy","sequence":"additional","affiliation":[{"name":"Cairo University Analytical Chemistry Department, Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh R","family":"Rezk","sequence":"additional","affiliation":[{"name":"Cairo University Analytical Chemistry Department, Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina A","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Future University in Egypt Pharmaceutical Chemistry Department, Faculty of Pharmacy, , End of 90th St., Fifth Settlement, New Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"issue":"12","key":"2024110205463342900_ref1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/bmc.2965","article-title":"Determination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics","volume":"27","author":"Wang","year":"2013","journal-title":"Biomedical Chromatography"},{"key":"2024110205463342900_ref2","volume-title":"The extra pharmacopoeia","author":"Martindale, I. 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