{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:15:31Z","timestamp":1760890531261,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100011171","name":"State Key Laboratory of Geohazard Prevention and Geoenvironment Protection","doi-asserted-by":"publisher","award":["SKLGP2020Z003"],"award-info":[{"award-number":["SKLGP2020Z003"]}],"id":[{"id":"10.13039\/501100011171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2019-YF05\u201302395-SN"],"award-info":[{"award-number":["2019-YF05\u201302395-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2021ZYD0055"],"award-info":[{"award-number":["2021ZYD0055"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372034","20672088"],"award-info":[{"award-number":["21372034","20672088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chiral sulfoximines have significant roles in pharmaceutical industry and agricultural chemicals. Furthermore, chiral structurally related sulfoximines are used for their wide potential applications in some uncharted territory. However, chromatographic study on these compounds has not been systematically performed. Herein, this paper describes the enantioseparation of 12 chiral sulfoximines on polysaccharide-based chiral stationary phases (CSPs). Separation factors of chiral column, high-performance liquid chromatography parameters such as mobile phase composition and column temperature were carefully investigated. Chiralcel OJ-H column can resolve all of the 12 compounds, while Chiralpak AD-H column and Chiralpak AS-H column can separate eight and nine molecules, respectively. The sulfoximines are effectively resolved with Chiralcel OJ-H column with a mixture of n-hexane\/2-propanol (80:20) as the mobile phase.<\/jats:p>","DOI":"10.1093\/chromsci\/bmad046","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T06:49:45Z","timestamp":1688366985000},"page":"838-843","source":"Crossref","is-referenced-by-count":1,"title":["Chromatographic Enantioseparation of Chiral Sulfoximines on Polysaccharide-Based Chiral Stationary Phases"],"prefix":"10.1093","volume":"61","author":[{"given":"Qinqin","family":"Tang","sequence":"first","affiliation":[{"name":"Chengdu University of Technology College of Materials, Chemistry & Chemical Engineering, , #1 East Third Road, Erxianqiao, Chenghua District, Chengdu 610059 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chengdu University of Technology College of Materials, Chemistry & Chemical Engineering, , #1 East Third Road, Erxianqiao, Chenghua District, Chengdu 610059 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-540X","authenticated-orcid":false,"given":"Qingle","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chengdu University of Technology College of Materials, Chemistry & Chemical Engineering, , #1 East Third Road, Erxianqiao, Chenghua District, Chengdu 610059 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"2023111009305884400_ref1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1021\/ar50070a003","article-title":"The utilization of sulfoximines and derivatives as reagents for organic synthesis","volume":"6","author":"Johnson","year":"1973","journal-title":"Accounts of Chemical Research"},{"key":"2023111009305884400_ref2","doi-asserted-by":"crossref","first-page":"112885","DOI":"10.1016\/j.ejmech.2020.112885","article-title":"Application of sulfoximines in medicinal chemistry from 2013 to 2020","volume":"209","author":"Han","year":"2021","journal-title":"European Journal of Medicinal Chemistry"},{"key":"2023111009305884400_ref3","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1039\/C9CS00483A","article-title":"Conversion and degradation pathways of sulfoximines","volume":"48","author":"Wiezorek","year":"2019","journal-title":"Chemical Society Reviews"},{"key":"2023111009305884400_ref4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejmech.2016.09.091","article-title":"Sulfoximines from a medicinal chemist\u2019s perspective: physicochemical and in vitro parameters relevant for drug discovery","volume":"126","author":"Frings","year":"2017","journal-title":"European Journal of Medicinal Chemistry"},{"key":"2023111009305884400_ref5","doi-asserted-by":"crossref","first-page":"9399","DOI":"10.1002\/anie.201302209","article-title":"Sulfoximines: a neglected opportunity in medicinal chemistry","volume":"52","author":"L\u00fccking","year":"2013","journal-title":"Angewandte Chemie International Edition"},{"key":"2023111009305884400_ref6","doi-asserted-by":"crossref","first-page":"14243","DOI":"10.1021\/acs.jmedchem.0c00960","article-title":"Sulfoximines as rising stars in modern drug discovery? Current status and perspective on an emerging functional group in medicinal chemistry","volume":"63","author":"M\u00e4der","year":"2020","journal-title":"Journal of Medicinal Chemistry"},{"key":"2023111009305884400_ref7","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1039\/C8QO01233D","article-title":"Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development","volume":"6","author":"L\u00fccking","year":"2019","journal-title":"Organic Chemistry Frontiers"},{"key":"2023111009305884400_ref8","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1021\/ja00114a009","article-title":"Regio- and enantioselective substitution of primary endocyclic allylic sulfoximines with organocopper and organocuprate reagents. The importance of iodide for the allylic substitution with organocopper compounds","volume":"117","author":"Gais","year":"1995","journal-title":"Journal of the American Chemical Society"},{"key":"2023111009305884400_ref9","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1021\/ja004261k","article-title":"Highly enantioselective hetero-Diels\u2212Alder reactions catalyzed by a C2-symmetric bis(sulfoximine) copper(II) complex","volume":"123","author":"Bolm","year":"2001","journal-title":"Journal of the American Chemical Society"},{"key":"2023111009305884400_ref10","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3762\/bjoc.8.164","article-title":"Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis","volume":"8","author":"Frings","year":"2012","journal-title":"Beilstein Journal of Organic 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