{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:49:36Z","timestamp":1790102976418,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160792"],"award-info":[{"award-number":["82160792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program","award":["CXTD22002"],"award-info":[{"award-number":["CXTD22002"]}]},{"DOI":"10.13039\/501100010890","name":"Chinese Government Scholarship","doi-asserted-by":"publisher","award":["202208360094"],"award-info":[{"award-number":["202208360094"]}],"id":[{"id":"10.13039\/501100010890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Postgraduate Innovation Special Fund Project","award":["YC2021-S489"],"award-info":[{"award-number":["YC2021-S489"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The herb Fissistigma oldhamii var. longistipitatum has been used for a long time in Asian folk medicine in the treatment of several diseases, including rheumatoid arthritis and other inflammatory conditions. Researchers in China and elsewhere have analyzed and characterized its chemical content. In this study, a UHPLC-Q-TOF-MS\/MS method, run in both positive and negative modes, was used to identify the main chemical compounds in dichloromethane extracts of this F. oldhamii variant. A total of 64 compounds, including 44 alkaloids and 20 flavonoids, were rapidly identified or tentatively characterized by comparing the molecular ion peaks and MS2 mass spectrometry fragment ions, combined with the mass spectrometry information of reference substances, appropriate fragmentation ions and related literatures. For the first time, the developed UHPLC-Q-TOF-MS\/MS analysis method allows for the determination of 64 compounds from extracts of the F. oldhamii variant. The method presented here produced results that will be useful in further studies of this herb.<\/jats:p>","DOI":"10.1093\/chromsci\/bmad066","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T03:56:30Z","timestamp":1693022190000},"page":"814-826","source":"Crossref","is-referenced-by-count":3,"title":["Rapid Identification of Alkaloids and Flavonoids in <i>Fissistigma oldhamii var. longistipitatum<\/i> by Ultra High-Performance Liquid Chromatography and Quadrupole Time-of-Flight Tandem Mass Spectrometry"],"prefix":"10.1093","volume":"61","author":[{"given":"Huizhen","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Jun","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University , 639 Longmian Road, Jiangning District, Nanjing 211198, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heying","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-0354","authenticated-orcid":false,"given":"Huilian","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"},{"name":"Jiangxi University of Chinese Medicine , Ministry of Education, , 816 Xingwan Road, Zhaoxian Town, Wanli District, Nanchang 330004, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"2023111009312262900_ref1","first-page":"115","article-title":"The chemical constituents of Fissistigma merr","volume":"14","author":"Liao","year":"1999","journal-title":"Acta Pharmaceutica Sinica"},{"key":"2023111009312262900_ref2","article-title":"Medicinal plants of East and Southeast Asia","volume-title":"Journal of Ethnopharmacology","author":"Richard"},{"key":"2023111009312262900_ref3","first-page":"988","article-title":"Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) 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The structure of moschatoline","volume":"20","author":"Bick","journal-title":"Australian Journal of Chemistry"},{"key":"2023111009312262900_ref31","article-title":"Characterization and quantitative analysis of phenylpropanoid amides in eggplant (Solanum melongena L.) by high performance liquid chromatography coupled with diode array detection and hybrid ion trap time-of-flight mass spectrometry","volume":"63","author":"Sun","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2023111009312262900_ref32","article-title":"Structural characterisation of alkaloids in leaves and roots of Stephania kwangsiensis by LC-QTOF-MS","volume":"29","author":"Shangguan","journal-title":"Phytochemical Analysis"},{"key":"2023111009312262900_ref33","article-title":"Rapid characterization of TCM Qianjinteng by UPLC-QTOF-MS and its application in the evaluation of three species of Stephania","volume":"156","author":"Xiao","journal-title":"Journal of Pharmaceutical and Biomedical 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