{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:33:06Z","timestamp":1780331586974,"version":"3.54.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773692"],"award-info":[{"award-number":["81773692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703683"],"award-info":[{"award-number":["81703683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Project from the Department of Science and Technology of Jilin Province","award":["20210101238JC"],"award-info":[{"award-number":["20210101238JC"]}]},{"name":"Natural Science Foundation Project from the Department of Science and Technology of Jilin Province","award":["YDZJ202301ZYTS188"],"award-info":[{"award-number":["YDZJ202301ZYTS188"]}]},{"name":"Science and Technology Project from the Department of Education of Jilin Province","award":["JJKH20210492KJ"],"award-info":[{"award-number":["JJKH20210492KJ"]}]},{"name":"Science and Technology Project from the Department of Education of Jilin Province","award":["JJKH20230546KJ"],"award-info":[{"award-number":["JJKH20230546KJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radix gentianae (RG) is a traditional Chinese medicine used for the treatment of acute and chronic hepatitis in clinic. However, the chemical profile of RG is still unconfirmed, which hindered the progress of pharmacological study and clinical application. In this study, ultra-high performance liquid chromatography together with quadrupole time-of-flight mass spectrometry techniques were employed to separate and characterize the chemical constituents in RG. Under the optimized conditions, a total of 60 compounds were rapidly identified or tentatively characterized. Results indicated that iridoid glucosides, flavonoids, organic acids, amino acids, saccharides and nucleosides were major constituents in RG. It is concluded the established method can help to clarify the substance basis and provide useful information for ascertaining the bioactive constituents and action mechanism of RG.<\/jats:p>","DOI":"10.1093\/chromsci\/bmad091","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T19:50:29Z","timestamp":1703101829000},"page":"864-871","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of the Chemical Constituents in <i>Radix gentianae<\/i> by Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry"],"prefix":"10.1093","volume":"62","author":[{"given":"Xu","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-0121","authenticated-orcid":false,"given":"Heyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, Jilin Medical University , 5 Jilin Street, Fengman District, Jilin 132013, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"2024110205461821600_ref1","first-page":"99","volume-title":"Chinese Pharmacopeia Committee; 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