{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:01:17Z","timestamp":1788199277318,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"crossref","award":["9711850002"],"award-info":[{"award-number":["9711850002"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u03b2-propiolactone is a common inactivator agent used in vaccines. Due to \u03b2-propiolactone carcinogenicity, complete hydrolysis of it is necessary to prevent cytotoxicity in mammalian cells. As a result, more attention should be paid to it at the clinic, and it is important to measure its trace amounts. \u03b2-propiolactone analysis is challenging due to its instability. A simple and fast gas chromatography\u2013mass spectrometry method was developed for quantitation of residual \u03b2-propiolactone in inactivated coronavirus disease 2019 (Covid-19) vaccines. Caprolactone was used as an internal standard in sample solutions; the analysis was performed after extraction of analyte from vaccine media by ethyl acetate. The validity of the method was studied with a linearity of r2\u00a0&amp;gt;\u20090.99 over the concentration range of 0.2\u201320\u00a0\u03bcg\/mL with the limit of detection and the limit of quantification of 0.07 and 0.20\u00a0\u03bcg\/mL, respectively. The target analyte \u03b2-propiolactone was not detected in the samples, demonstrating the test samples were qualified. The established method can be used for quality control of inactivated Covid-19 vaccines.<\/jats:p>","DOI":"10.1093\/chromsci\/bmae049","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T01:32:56Z","timestamp":1724463176000},"page":"905-911","source":"Crossref","is-referenced-by-count":2,"title":["A GC\u2013MS Method for Determination of \u03b2-Propiolactone Residues in Inactivated Covid-19 Vaccines"],"prefix":"10.1093","volume":"62","author":[{"given":"Seyedeh Zohreh","family":"Mirjalili","sequence":"first","affiliation":[{"name":"Department of Drug and Food Control , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]},{"name":"Tehran University of Medical Sciences , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Tamiji","sequence":"additional","affiliation":[{"name":"Department of Drug and Food Control , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]},{"name":"Tehran University of Medical Sciences , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]},{"name":"Food and Drug Administration, Tehran University of Medical Sciences , Engelab Ave, Tehran 14155-6451,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoosh","family":"Shirangi","sequence":"additional","affiliation":[{"name":"Department of Drug and Food Control , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]},{"name":"Tehran University of Medical Sciences , Faculty of Pharmacy, , Engelab Ave, Tehran 14155-6451,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-2917","authenticated-orcid":false,"given":"Mohsen","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry , Faculty of Pharmacy, , Engelab Ave, Tehran 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