{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:50Z","timestamp":1753876070560,"version":"3.41.2"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nowadays, there is a strong interest in the scientific community in developing innovative methodologies within a green analytical chemistry framework. Herein, we introduce the first chromatographic approaches for the concurrent estimation of paracetamol (PAR), carbinoxamine (CRX), and pseudoephedrine (PSE) intended to relieve COVID-19 and common cold symptoms. The first method was thin layer chromatography (TLC) densitometry, which depends on the separation of the studied medications on TLC silica gel plates using ethyl acetate: methanol: ammonia (7.0: 3.0: 0.2, by volume) as the developing system, and were scanned at 208.0\u00a0nm. The data were linear in the ranges of 1\u201325\u00a0\u03bcg\/band for PAR, 1\u201325\u00a0\u03bcg\/band for PSE and 0.1\u20135\u00a0\u03bcg\/band for CRX. The second method was reversed-phase high-performance liquid chromatography separation on a Kromasil C18 column using a mixture of 0.01\u00a0M phosphate buffer containing 0.1% triethylamine (pH\u00a03.5) adjusted with orthophosphoric acid and ethanol at a flow rate of 1.0\u2009mL\/min in a gradient program. The separated peaks were detected at 215.0\u2009nm over a concentration range of 10\u2013250\u00a0\u03bcg\/mL for PAR, 5\u201335\u00a0\u03bcg\/mL for PSE, and 0.5\u201325\u00a0\u03bcg\/mL for CRX. Both approaches were validated according to International Conference on Harmonization (ICH) guidelines. Finally, the impact of these methods on the environment was evaluated by many tools.<\/jats:p>","DOI":"10.1093\/chromsci\/bmae050","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T12:04:52Z","timestamp":1727352292000},"source":"Crossref","is-referenced-by-count":1,"title":["Novel Green Chromatographic Approaches for Estimation of a Triple Common Cold Pharmaceutical Combination"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-3542","authenticated-orcid":false,"given":"Rabab M","family":"Soliman","sequence":"first","affiliation":[{"name":"Ministry of Health and Population, Directorate of Health Affairs, Ismailia Health Administration , Ismailia 41511 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Rostom","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]},{"name":"Cairo University , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin M","family":"Fayez","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]},{"name":"Cairo University , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia M","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]},{"name":"Cairo University , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-8848","authenticated-orcid":false,"given":"Hany H","family":"Monir","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]},{"name":"Cairo University , Faculty of Pharmacy, , Kasr El-Aini Street, Cairo 11562 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"issue":"3","key":"2024092612044061800_ref1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4102\/safp.v59i3.4704","article-title":"Colds and flu\u2014an overview of the management","volume":"59","author":"Ismail","year":"2017","journal-title":"South African Family Practice"},{"key":"2024092612044061800_ref2","first-page":"159","volume-title":"The Common Cold. 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