{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:44:29Z","timestamp":1781606669834,"version":"3.54.5"},"reference-count":23,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Novel C18-functionalized magnetic nanomaterials; i.e., C18@poly-styrene-divinylbenzene-glycidyl methacrylate-Fe3O4 (C18@PS-DVB-GMA-Fe3O4) have been synthesized by using N, N-dimethyloctadecylamine as modifying agent, which could be beneficial to remove the blood phospholipids. The C18@PS-DVB-GMA-Fe3O4 nanoparticles have been used and evaluated in the Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) procedure for human plasma prior to the analysis of propofol by supercritical fluid chromatography (SFC). In the QuEChERS procedure, human plasma samples are directly mixed with extraction solvent and C18@PS-DVB-GMA-Fe3O4 nanoparticles, and the extraction and cleanup procedures have been accomplished simultaneously. The SFC separation was performed with a C18 column (Thermo Scientific\u2122 Acclaim\u2122 120, 250\u2009\u00d7\u20094. 6\u00a0mm, 5\u00a0\u03bcm) within 5\u00a0min, using thymol as the internal standard. Supercritical carbon dioxide was used as the mobile phase with methanol as the cosolvent at the flow rate of 1.0\u00a0mL\/min. The column temperature was 38\u00b0C, and detection wavelength was 275\u00a0nm. A good linearity was obtained among the propofol concentration range of 0.5\u201310\u00a0mg\/L (R2\u2009=\u20090.9997) with the limit of detection of 0.17\u00a0mg\/L. Recoveries were in the range of 76.5\u201391.9%, with RSD less than 7.9%. These results suggested that method is convenient, rapid with high accuracy and little matrix effect, and suitable for rapid determination of propofol plasma concentration.<\/jats:p>","DOI":"10.1093\/chromsci\/bmae053","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T15:02:31Z","timestamp":1729609351000},"source":"Crossref","is-referenced-by-count":1,"title":["Fast Determination of Propofol in Human Plasma Using C18-Functionalized Magnetic Nanomaterials Followed by Supercritical Fluid Chromatography"],"prefix":"10.1093","author":[{"given":"Shan-Yan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Ningbo No. 2 Hospital , 41 Northwest street, Ningbo, Zhejiang 315010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Ningbo No. 2 Hospital , 41 Northwest street, Ningbo, Zhejiang 315010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Occupational Health and Radiation Protection, Zhejiang Province Center for Disease Control and Prevention , 3399 Binsheng Road, Hangzhou 310051 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Li","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Engineering, Zhejiang Shuren University , 8 Shuren Road, Hangzhou 310015 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biosafety detection for Zhejiang Market Regulation, Zhejiang Fangyuan Test Group Co., LTD , 300 Xiasha Road, Hangzhou 310018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-8419","authenticated-orcid":false,"given":"Yong-Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Engineering, Zhejiang Shuren University , 8 Shuren Road, Hangzhou 310015 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"2024102214121122200_ref1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0140-6736(08)60878-8","article-title":"An estimation of the global volume of surgery: A modelling strategy based on available data","volume":"372","author":"Weiser","year":"2008","journal-title":"The Lancet"},{"key":"2024102214121122200_ref2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/bjaceaccp\/mkn048","article-title":"Respiratory gas analysis","volume":"9","author":"Langton","year":"2009","journal-title":"Continuing Education in Anaesthesia Critical Care & Pain"},{"key":"2024102214121122200_ref3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/00000542-198010000-00008","article-title":"Determination and applications of MAC","volume":"53","author":"Quasha","year":"1980","journal-title":"Anesthesiology"},{"key":"2024102214121122200_ref4","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1097\/00000542-196511000-00010","article-title":"Minimum alveolar Anesthetic concentration a standard of Anesthetic potency","volume":"26","author":"Eger","year":"1965","journal-title":"Anesthesiology"},{"key":"2024102214121122200_ref5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.mehy.2006.08.030","article-title":"Uncomplicated general anesthesia in the elderly results in cognitive decline: Does cognitive decline predict morbidity and mortality?","volume":"68","author":"Lewis","year":"2007","journal-title":"Medical Hypotheses"},{"key":"2024102214121122200_ref6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0016-5107(99)70281-6","article-title":"Efficacy and safety of intravenous propofol sedation during routine ERCP a prospective, controlled study","volume":"49","author":"Wehrmann","year":"1999","journal-title":"Gastrointestinal Endoscopy"},{"key":"2024102214121122200_ref7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jpba.2015.02.035","article-title":"Simultaneous determination of propofol and its glucuronide in whole blood by liquid chromatography-electrospray tandem mass spectrometry and the influence of sample storage conditions on the reliability of the test results","volume":"109","author":"Sorensen","year":"2015","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2024102214121122200_ref8","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/00000542-198809000-00011","article-title":"Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia","volume":"69","author":"Shafer","year":"1988","journal-title":"Anesthesiology"},{"key":"2024102214121122200_ref9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.snb.2018.04.082","article-title":"Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum","volume":"269","author":"Stradolini","year":"2018","journal-title":"Sensors and Actuators B: Chemical"},{"key":"2024102214121122200_ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.forsciint.2015.07.013","article-title":"LC-MS\/MS and GC-MS methods in propofol detection: Evaluation of the two analytical procedures","volume":"256","author":"Vaiano","year":"2015","journal-title":"Forensic Science International"},{"key":"2024102214121122200_ref11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/chromsci\/bmr042","article-title":"Determination of propofol using high performance liquid chromatography in whole blood with fluorescence detection","volume":"50","author":"Yarbrough","year":"2012","journal-title":"Journal of Chromatographic Science"},{"key":"2024102214121122200_ref12","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/chromsci\/bmy027","article-title":"Simultaneous HPLC determination of cisatracurium and propofol in human plasma via fluorometric detection","volume":"56","author":"Ayad","year":"2018","journal-title":"Journal of Chromatographic Science"},{"key":"2024102214121122200_ref13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/jcpt.13038","article-title":"A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood","volume":"45","author":"Qi","year":"2020","journal-title":"Journal of Clinical Pharmacy and Therapeutics"},{"key":"2024102214121122200_ref14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jpba.2017.12.043","article-title":"Design and validation of an automated solid phase extraction liquid chromatography coupled mass spectrometry method for the quantification of propofol in plasma","volume":"150","author":"Maurer","year":"2018","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2024102214121122200_ref15","doi-asserted-by":"publisher","first-page":"462360","DOI":"10.1016\/j.chroma.2021.462360","article-title":"Fluoride-assisted liquid chromatography-tandem mass spectrometry method for simultaneous analysis of propofol and its metabolites without derivatization in urine","volume":"1652","author":"Lee","year":"2021","journal-title":"Journal of Chromatography. A"},{"key":"2024102214121122200_ref16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jpba.2016.04.026","article-title":"Determination of total and unbound propofol in patients during intensive care sedation by ultrafiltration and LC-MS\/MS","volume":"126","author":"Eisenried","year":"2016","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2024102214121122200_ref17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.aca.2020.10.043","article-title":"Rapid quantitative determination of blood propofol concentration throughout perioperative period by negative photoionization ion mobility spectrometer with solvent-assisted neutral desorption","volume":"1142","author":"Xiao","year":"2021","journal-title":"Analytica Chimica Acta"},{"key":"2024102214121122200_ref18","doi-asserted-by":"publisher","first-page":"e20056","DOI":"10.1016\/s1872-2040(20)60011-1","article-title":"Facile determination of anesthetic drug propofol based on electrochemiluminescence quenching","volume":"48","author":"Fan","year":"2020","journal-title":"Chinese J Anal Chem"},{"issue":"2","key":"2024102214121122200_ref19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/jaoac\/86.2.412","article-title":"Fast and easy multiresidue method employing acetonitrile extraction\/partitioning and dispersive solid-phase extraction for the determination of pesticide residues in produce","volume":"86","author":"Anastassiades","year":"2003","journal-title":"J AOAC Inter"},{"issue":"6","key":"2024102214121122200_ref20","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s00216-007-1610-7","article-title":"Analysis of pesticide residues using the quick easy cheap effective rugged and safe (QuEChERS) pesticide multiresidue method in combination with gas and liquid chromatography and tandem mass spectrometric detection","volume":"389","author":"Paya","year":"2007","journal-title":"Analytical and Bioanalytical Chemistry"},{"issue":"1","key":"2024102214121122200_ref21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00128-004-0388-y","article-title":"Evaluation of the quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach to pesticide residue analysis","volume":"73","author":"Schenck","year":"2004","journal-title":"B Environ Contam Tox"},{"issue":"1","key":"2024102214121122200_ref22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10337-016-3206-x","article-title":"Determination of multiple pesticides in human blood using modified QuEChERS method with Fe3O4 magnetic nanoparticles and GC-MS","volume":"80","author":"Yu","year":"2017","journal-title":"Chromatographia"},{"key":"2024102214121122200_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463022","article-title":"Simultaneous determination of 12 illicit drugs in human plasma by the PRiME clover-shaped nano-titania functionalized covalent organic frameworks pass-through cleanup procedure followed by ultra-performance liquid chromatography-tandem mass spectrometry","volume":"1671","author":"Zhang","year":"2022","journal-title":"Journal of Chromatography A"}],"container-title":["Journal of Chromatographic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/chromsci\/advance-article-pdf\/doi\/10.1093\/chromsci\/bmae053\/59959378\/bmae053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/chromsci\/advance-article-pdf\/doi\/10.1093\/chromsci\/bmae053\/59959378\/bmae053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T15:02:34Z","timestamp":1729609354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/chromsci\/advance-article\/doi\/10.1093\/chromsci\/bmae053\/7831151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":23,"URL":"https:\/\/doi.org\/10.1093\/chromsci\/bmae053","relation":{},"ISSN":["0021-9665","1945-239X"],"issn-type":[{"value":"0021-9665","type":"print"},{"value":"1945-239X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"article-number":"bmae053"}}