{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:50:27Z","timestamp":1782503427186,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Science and technology project of Jiangxi Administration of traditional Chinese Medicine","award":["2022Z028"],"award-info":[{"award-number":["2022Z028"]}]},{"name":"Natural Science Foundation of Jiangxi Province of China","award":["20212BAB206082"],"award-info":[{"award-number":["20212BAB206082"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>San-Huang-Xie-Xin-Tang (SHXXT), a traditional Chinese medicine formula composed of Coptidis rhizome (CR), Scutellariae radix (SR) and Rhei rhizome (RR), is widely used to treat hypertension, gastritis and peptic ulcer clinically. However, the chemical constituent of SHXXT is still unclear due to its complexity, which hindered the discovery of effective compounds and quality control. Thus, an in-depth understanding of its chemical constituents is very essential. To address this problem, comprehensive analysis of chemical constituents of SHXXT was performed by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS\/MS). As a result, 45 compounds were identified, including 8 phenolic acids, 15 flavonoids, 13 alkaloids, 8 anthraquinones and 1 lignan. Among them, 17 compounds were from CR, 17 compounds were from SR and 11 compounds were from RR. This established method can systematically and rapidly analyze the chemical constituents in SHXXT, which provides chemical foundation for further research on effective substances and action mechanism of SHXXT.<\/jats:p>","DOI":"10.1093\/chromsci\/bmae056","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:28:35Z","timestamp":1730806115000},"source":"Crossref","is-referenced-by-count":2,"title":["Rapid Characterization and Identification of the Chemical Constituents in San-Huang-Xie-Xin-Tang, a Traditional Chinese Medicine Formula, by High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry"],"prefix":"10.1093","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Xinjiang Uygur Autonomous Region Infectious Disease Hospital Department of Pharmacy, , No. 100, North Lane 1, Kashgar East Road, Xinshi District, Urumqi 830010,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangzhong Pharmaceutical Co, Ltd Drug Research and Development Department, , No. 1899 Meiling Road, Nanchang 330103,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmo","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiujiang University School of Pharmaceutical and Life Sciences, , Qianjin Road 551, Jiujiang 332005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasi","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiujiang University School of Pharmaceutical and Life Sciences, , Qianjin Road 551, Jiujiang 332005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiujiang University School of Pharmaceutical and Life 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