{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:11:04Z","timestamp":1772691064045,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An environmentally friendly HPLC method was developed to estimate angiotensin receptor blocker (telmisartan) and calcium channel blockers (cilnidipine, benidipine and azelnidipine) in a single run. Separation was achieved using a C18 column (250\u00a0mm \u00d7 4.6\u00a0mm, 5\u00a0\u03bcm), employing an eluent consisting of 10\u00a0mM potassium phosphate buffer (pH\u00a05), methanol and acetonitrile in a ratio of (25:45:30, v\/v\/v) at 1.0\u00a0mL\/min flow. Validation of the method was confirmed, following ICH guidelines. Calibration graphs were found to be linear in the ranges of 2.5\u201340, 0.625\u201310, 0.5\u20138 and 1\u201316\u00a0\u03bcg\/mL corresponding to telmisartan, cilnidipine, benidipine and azelnidipine, respectively. To assess the environmental impact of the method, five greenness evaluation criteria, namely, the Green Analytical Procedure Index, Analytical GREEness, Chlortox Scale, Blue Applicability Grade Index, and Red-Blue-Green 12, were adopted. Concerning all the tools, the proposed method was found to be green.<\/jats:p>","DOI":"10.1093\/chromsci\/bmaf059","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:59:11Z","timestamp":1764075551000},"source":"Crossref","is-referenced-by-count":1,"title":["Greenness Assessment of HPLC-UV Method for Simultaneous Estimation of Four Antihypertensive Drugs"],"prefix":"10.1093","volume":"63","author":[{"given":"Kavita","family":"Suthar","sequence":"first","affiliation":[{"name":"Department of Quality Assurance, SSR College of Pharmacy , Sayli Road, Sayli Silvassa, Union Territory of Dadra Nagar Haveli & Daman Diu 396 230 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8495-8341","authenticated-orcid":false,"given":"Sonal","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance, SSR College of Pharmacy , Sayli Road, Sayli Silvassa, Union Territory of Dadra Nagar Haveli & Daman Diu 396 230 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"2025120912283406700_ref1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nature Reviews Nephrology"},{"key":"2025120912283406700_ref2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.15713\/ins.johtn.0189","article-title":"Newer drug choices in hypertension treatment","volume":"6","author":"Sharma","year":"2020","journal-title":"Hypertension"},{"key":"2025120912283406700_ref3","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.22270\/jddt.v9i3-s.3090","article-title":"Azelnidipine: A review on therapeutic role in hypertension","volume":"9","author":"Shewale","year":"2019","journal-title":"Journal of Drug Delivery and Therapeutics"},{"key":"2025120912283406700_ref4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5005\/jp-journals-10042-1084","article-title":"A review on properties, application, and analytical methods of an antihypertensive drug efonidipine","volume":"10","author":"Patel","year":"2019","journal-title":"Journal of Health Sciences & Research"},{"issue":"1","key":"2025120912283406700_ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/147323001204000101","article-title":"Efficacy and safety of angiotensin II type 1 receptor blocker\/calcium channel blocker combination therapy for hypertension: Focus on a single-pill fixed-dose combination of valsartan and amlodipine","volume":"40","author":"Miura","year":"2012","journal-title":"Journal of International Medical Research"},{"key":"2025120912283406700_ref6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1751-7176.2011.00513.x","article-title":"Calcium channel blockers","volume":"13","author":"Elliott","year":"2011","journal-title":"Journal of Clinical Hypertension"},{"key":"2025120912283406700_ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1470320310370852","article-title":"Angiotensin II type 1 receptor blockers: Class effects versus molecular effects. 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