{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:38:07Z","timestamp":1786995487562,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Nature Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Projects of Natural Science Foundation of Jiangsu Higher Education Institutions","award":["82374038"],"award-info":[{"award-number":["82374038"]}]},{"name":"Major Projects of Natural Science Foundation of Jiangsu Higher Education Institutions","award":["82204621"],"award-info":[{"award-number":["82204621"]}]},{"name":"Major Projects of Natural Science Foundation of Jiangsu Higher Education Institutions","award":["21KJA360005"],"award-info":[{"award-number":["21KJA360005"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Scutellariae barbatae Herba, the dried whole plant of S.barbatae D. Don, has been documented in the Chinese Pharmacopoeia since 1985. The chemical constituents of S. barbatae Herba are complex. And comprehensive analysis of the chemical components in S. barbatae Herba is still scarcely studied. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used in both negative and positive ion modes to comprehensively analyze chemical constituents of S. barbatae Herba. Moreover, the fragmentation pathways of compounds were explained in brief. According to tandem mass spectrometry fragmentation data and previous reports, a total of 39 compounds were identified, including 19 flavonoids, 4 neo-clerodane diterpenoids, 1 neo-clerodane diterpenoid alkaloid, 3 triterpenes, 5 fatty acids, 1 lignin, 1 monoterpene phenol, and 4 other constituents. More fragments of information are formed in the compounds, and the fragmentation pathways were explained simply. The developed analytical method is simple, reliable, and effective, providing comprehensive information on the metabolite profile of S. barbatae Herba, which may enhance its quality control and further utilization.<\/jats:p>","DOI":"10.1093\/chromsci\/bmag023","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:36:19Z","timestamp":1784979379000},"source":"Crossref","is-referenced-by-count":0,"title":["Identification and characterization of chemical constituents in\n                    <i>Scutellariae barbatae<\/i>\n                    Herba by UHPLC-QTOF-MS"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0435-3638","authenticated-orcid":false,"given":"Xuelin","family":"Zong","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jiangsu Ocean University , No. 59, Cangwu Road, Haizhou District, Lianyungang, Jiangsu \u00a0222005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Qin","sequence":"additional","affiliation":[{"name":"Lianyungang Chinese Medicine Hospital , No. 160, Chaoyang Middle Road, Haizhou District, Lianyungang, Jiangsu 222004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Hui","sequence":"additional","affiliation":[{"name":"Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine , No. 138, Xianlin Avenue, Qixia District, Nanjing, Jiangsu 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Ying","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department of Nanjing Chinese Medicine, Hospital Affiliated to Nanjing University of Chinese Medicine , No. 157, Daming Road, Qinhuai District, Nanjing, Jiangsu 210022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-523X","authenticated-orcid":false,"given":"Xun","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Ocean University , No. 59, Cangwu Road, Haizhou District, Lianyungang, Jiangsu \u00a0222005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Ocean University , No. 59, Cangwu Road, Haizhou District, Lianyungang, Jiangsu \u00a0222005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunming","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu Ocean University , No. 59, Cangwu Road, Haizhou District, Lianyungang, Jiangsu \u00a0222005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"23","key":"2026081715064065500_ref1","doi-asserted-by":"publisher","first-page":"8185","DOI":"10.3390\/molecules27238185","article-title":"Stepwise diagnostic product ions filtering strategy for rapid discovery of diterpenoids in Scutellaria barbata based on UHPLC-Q-exactive-orbitrap-MS","volume":"27","author":"Zhou","year":"2020","journal-title":"Molecules"},{"key":"2026081715064065500_ref2","doi-asserted-by":"publisher","first-page":"112230","DOI":"10.1016\/j.phytochem.2019.112230","article-title":"Phytotoxic neo-clerodane diterpenoids from the aerial parts of Scutellaria barbata","volume":"171","author":"Li","year":"2020","journal-title":"Phytochemistry"},{"key":"2026081715064065500_ref3","doi-asserted-by":"publisher","first-page":"1072547","DOI":"10.3389\/fphar.2022.1072547","article-title":"Study on the mechanism of action of Scutellaria barbata on hepatocellular carcinoma based on network pharmacology and bioinformatics","volume":"13","author":"Yang","year":"2023","journal-title":"Frontiers in Pharmacology"},{"issue":"12","key":"2026081715064065500_ref4","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.3390\/molecules27123803","article-title":"Anti-photoaging activity of Scutellaria barbata D. 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