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Chromatographic separation of the total extract was carried out on a Waters chromatographic column (100\u00a0mm\u2009\u00d7\u20092.1\u00a0mm, 1.7\u00a0\u03bcm) with a gradient elution program using a mobile phase system consisting of 0.1% aqueous formic acid (v\/v, solvent A) and acetonitrile (solvent B). Mass spectrometric detection was conducted in both positive and negative ion modes. A total of 43 chemical components were successfully identified, including 29 alkaloids and 14 terpenoids. Furthermore, the mass fragmentation behaviors and characteristic fragment ions of protoberberine isoquinoline alkaloids, aporphine alkaloids and diterpenes were systematically analyzed. This study provides reliable reference data for the identification and compositional analysis of chemical constituents in Tinosporae Radix and its homologous medicinal herbs. The findings lay a solid foundation for exploring the pharmacodynamic material basis and chemical profiling of this traditional Chinese medicinal herb, supporting its quality evaluation and further pharmacological mechanism research.<\/jats:p>","DOI":"10.1093\/chromsci\/bmag027","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:32:54Z","timestamp":1788867174000},"source":"Crossref","is-referenced-by-count":0,"title":["Analysis of principal components and fragmentation patterns of\n                    <i>Tinosporae Radix<\/i>\n                    by ultra high-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry"],"prefix":"10.1093","volume":"64","author":[{"given":"Dianchao","family":"Tang","sequence":"first","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine , Wanli Campus, No. 1688 Meiling Avenue, Xinjian District, Nanchang City, Jiangxi Province, 330004 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine , Wanli Campus, No. 1688 Meiling Avenue, Xinjian District, Nanchang City, Jiangxi Province, 330004 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine , Wanli Campus, No. 1688 Meiling Avenue, Xinjian District, Nanchang City, Jiangxi Province, 330004 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University 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