{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:30Z","timestamp":1790168490230,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Currently, many researchers strive to create eco-conscious methods for drug separation to avoid hazardous solvents. In line with this objective, this study focuses on developing two green chromatographic methods, TLC and UPLC, to determine the mixture of carvedilol (CAR) and ivabradine (IVA) used for controlling stable angina symptoms, along with their oxidative degradates. The TLC method employed toluene: methanol: ammonia (8:2:0.2, by volume) as a mobile phase and silica gel plates as the stationary phase, with detection at 270.0\u00a0nm using concentration ranges of 0.5-8.0\u00a0\u03bcg\/band for each drug. The optimized UPLC method utilized a mobile phase of ethanol: 0.1% triethylamine adjusted by acetic acid to pH\u00a06.4 (40:60\u00a0v\/v) on an Agilent Poroshell C18 (150\u00a0mm\u2009\u00d7\u20093\u00a0mm) column, with a 0.3\u00a0mL\/min flow rate at 30\u00b0C and fluorimetric detection at 285.0\u00a0nm excitation and 330.0\u00a0nm emission, with linearity of 0.2-12.0\u00a0\u03bcg\/mL for both drugs. Green assessment of the proposed methods with 82 and 78 green Eco-scores, AGREE score values of 0.77 and 0.72 for UPLC and TLC methods, respectively were performed. Moreover, statistical comparison of the proposed methods with reported and official methods was conducted. Additionally, structure elucidation, molecular docking and ADMET assessment of the degradates were successfully performed.<\/jats:p>","DOI":"10.1093\/chromsci\/bmag028","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:46:15Z","timestamp":1789127175000},"source":"Crossref","is-referenced-by-count":0,"title":["Eco-friendly stability-indicating chromatographic methods with integrated molecular docking and ADMET evaluation for simultaneous determination of carvedilol and ivabradine"],"prefix":"10.1093","volume":"64","author":[{"given":"Haitham A","family":"El Fiky","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt , End of 90th St., Fifth Settlement, New Cairo 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha F","family":"Abd El Ghany","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Ain shams University , Abbasiya, Cairo 11566 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M","family":"Badawey","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Cairo University , Kasr El-Aini St, Cairo 11562 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermine V","family":"Fares","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Ain shams University , Abbasiya, Cairo 11566 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina A","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt , End of 90th St., Fifth Settlement, New Cairo 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026092308061877800_ref1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/9781119889878.ch8","article-title":"Advanced approaches in green univariate spectrophotometric methods","author":"Lotfy","year":"2023","journal-title":"Sustainable Approaches in Pharmaceutical Sciences"},{"key":"2026092308061877800_ref2","doi-asserted-by":"publisher","first-page":"115598","DOI":"10.1016\/j.jpba.2023.115598","article-title":"Exquisite integration of quality-by-design and green analytical approaches for simultaneous determination of xylometazoline and antazoline in eye drops and rabbit aqueous humor, application to stability study","volume":"235","author":"Hussein","year":"2023","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"9","key":"2026092308061877800_ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43094-023-00548-3","article-title":"Rapid and validated UHPLC method for simultaneous determination of sofosbuvir, ledipasvir and paracetamol as commonly repurposed drugs for COVID-19 treatment: Application in spiked human plasma","volume":"92","author":"Gamal","year":"2023","journal-title":"Future Journal of Pharmaceutical Sciences"},{"issue":"1","key":"2026092308061877800_ref4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/jaoacint\/qsab110","article-title":"Ultra-performance liquid chromatographic and densitometric methods for sensitive determination of xipamide and triamterene in pure and pharmaceutical dosage forms","volume":"105","author":"Fares","year":"2022","journal-title":"Journal of AOAC International"},{"key":"2026092308061877800_ref5","first-page":"309","volume-title":"British pharmacopoeia commission","author":"Pharmacopoeia","year":"2017"},{"key":"2026092308061877800_ref6","first-page":"2585","volume-title":"PubChem compound summary for CID, carvedilol","author":"National Center for Biotechnology Information","year":"2022"},{"key":"2026092308061877800_ref7","first-page":"132999","volume-title":"PubChem compound summary for CID, ivabradine","author":"National Center for Biotechnology Information","year":"2022"},{"issue":"2","key":"2026092308061877800_ref8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1742-1241.2006.00817.x","article-title":"Ivabradine\u2013the first selective sinus node if channel inhibitor in the treatment of stable angina","volume":"60","author":"Sulfi","year":"2006","journal-title":"International Journal of Clinical Practice"},{"issue":"3","key":"2026092308061877800_ref9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.5267\/j.ccl.2022.3.002","article-title":"Three spectrophotometric approaches for measuring ratio spectra of ivabradine and carvedilol in a binary mixture using green analytical principles","volume":"1","author":"Chanduluru","year":"2022","journal-title":"Curr. 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