{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:44:47Z","timestamp":1780933487474,"version":"3.54.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/chromsci\/bmy113","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T20:18:35Z","timestamp":1544127515000},"page":"312-322","source":"Crossref","is-referenced-by-count":5,"title":["High-Performance Thin-Layer Chromatography Method for Simultaneous Determination of Antipsychotic and Medicinally Important Five \u03b2-Carboline Alkaloids"],"prefix":"10.1093","volume":"57","author":[{"given":"Nitin Suryakant","family":"Kadam","sequence":"first","affiliation":[{"name":"Department of Botany, Savitribai Phule Pune University, Pune, MH, India"},{"name":"Department of Chemistry, Savitribai Phule Pune University, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana Ashokrao","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Botany, Savitribai Phule Pune University, Pune, MH, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja Jignesh","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Savitribai Phule Pune University, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tukaram Dayaram","family":"Nikam","sequence":"additional","affiliation":[{"name":"Department of Botany, Savitribai Phule Pune University, Pune, MH, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1021\/np50051a026","article-title":"\u03b2-carboline alkaloids from the marine bryozoan Costaticella hastate","volume":"50","author":"Blackman","year":"1987","journal-title":"Journal of Natural Products"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C2","first-page":"921","article-title":"Isolation of harman and norharman from Nocardia sp. and their inhibitory activity against plant seedlings","volume":"51","author":"Yomosa","year":"1987","journal-title":"Agricultural and Biological Chemistry"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/978-3-642-22144-6_20","volume-title":"Natural products","author":"Nikam","year":"2013"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0031-9422(00)82825-3","article-title":"The isolation of harmane and norharmane from tobacco and cigarette smoke","volume":"1","author":"Poindexter","year":"1962","journal-title":"Phytochemistry"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4347(93)80217-R","article-title":"Gas chromatographic\u2014mass spectrometric screening procedure for the identification of formaldehyde-derived tetrahydro-\u03b2-carbolines in human urine","volume":"614","author":"Musshoff","year":"1993","journal-title":"Journal of Chromatography B"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fct.2004.01.001","article-title":"An overview of the effects of tobacco ingredients on smoke chemistry and toxicity","volume":"42","author":"Baker","year":"2004","journal-title":"Food and Chemical Toxicology"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.sjbs.2010.12.004","article-title":"Dietary effects of harmine, a \u03b2-carboline alkaloid, on development, energy reserves and a amylase activity of Plodia interpunctella H\u00fcbner [Lepidoptera: Pyralidae]","volume":"19","author":"Bouayad","year":"2011","journal-title":"Saudi Journal of Biological Sciences"},{"issue":"6","key":"key\n\t\t\t\t2019032012170264400_bmy113C8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.fitote.2008.03.010","article-title":"Ethnobotany of plants used by the Thari people of Nara Desert, Pakistan","volume":"79","author":"Qureshi","year":"2008","journal-title":"Fitoterapia"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.fct.2009.12.019","article-title":"\u03b2-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)","volume":"48","author":"Herraiz","year":"2010","journal-title":"Food and Chemical Toxicology"},{"issue":"21","key":"key\n\t\t\t\t2019032012170264400_bmy113C10","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1111\/j.1742-4658.2009.07346.x","article-title":"Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation","volume":"276","author":"G\u00f6ckler","year":"2009","journal-title":"The FEBS Journal"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C11","doi-asserted-by":"crossref","first-page":"e19264","DOI":"10.1371\/journal.pone.0019264","article-title":"\u03b2-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer\u2019s disease-related sites","volume":"6","author":"Frost","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuint.2015.07.018","article-title":"Plant alkaloids as drug leads for Alzheimer\u2019s disease","volume":"89","author":"Ng","year":"2015","journal-title":"Neurochemistry International"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1189\/jlb.68.2.260","article-title":"Combined inhibition of indoleamine 2, 3-dioxygenase and nitric oxide synthase modulates neurotoxin release by interferon-\u03b3-activated macrophages","volume":"68","author":"Chiarugi","year":"2000","journal-title":"Journal of Leukocyte Biology"},{"issue":"8","key":"key\n\t\t\t\t2019032012170264400_bmy113C14","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.pnpbp.2009.07.021","article-title":"Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus","volume":"33","author":"Fortunato","year":"2009","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vph.2008.11.008","article-title":"Antiplatelet activity of \u03b2-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLC\u03b32 phosphorylation","volume":"50","author":"Im","year":"2009","journal-title":"Vascular Pharmacology"},{"issue":"4","key":"key\n\t\t\t\t2019032012170264400_bmy113C16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.brainresbull.2009.09.008","article-title":"Effects of \u03b2-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties","volume":"81","author":"Fortunato","year":"2010","journal-title":"Brain Research Bulletin"},{"issue":"5773","key":"key\n\t\t\t\t2019032012170264400_bmy113C17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/286606a0","article-title":"Ethyl \u03b2-carboline-3-carboxylate shows differential benzodiazepine receptor interaction","volume":"286","author":"Nielsen","year":"1980","journal-title":"Nature"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.euroneuro.2005.08.005","article-title":"Antidepressant-like effect of harmane and other \u03b2-carbolines in the mouse forced swim test","volume":"16","author":"Farzin","year":"2006","journal-title":"European Neuropsychopharmacology"},{"issue":"10","key":"key\n\t\t\t\t2019032012170264400_bmy113C19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ejmech.2005.04.008","article-title":"Design, synthesis and in vitro and in vivo antitumor activities of novel \u03b2-carboline derivatives","volume":"40","author":"Cao","year":"2005","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"7","key":"key\n\t\t\t\t2019032012170264400_bmy113C20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/BF02978835","article-title":"A study on the antitumoral and differentiation effects of Peganum harmala derivatives in combination with ATRA on leukaemic cells","volume":"30","author":"Zaker","year":"2007","journal-title":"Archives of Pharmacal Research"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ptr.2650010106","article-title":"Antileishmanial activity of harmaline and other tryptamine derivatives","volume":"1","author":"Evans","year":"1987","journal-title":"Phytotherapy Research"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exppara.2004.04.002","article-title":"In vitro activity of the \u03b2-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum","volume":"106","author":"Di Giorgio","year":"2004","journal-title":"Experimental Parasitology"},{"issue":"6","key":"key\n\t\t\t\t2019032012170264400_bmy113C23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1128\/AAC.38.6.1292","article-title":"Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2\u2032, 3\u2032-dideoxycytidine and its 5-fluoro derivative in vitro","volume":"38","author":"Gosselin","year":"1994","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"17","key":"key\n\t\t\t\t2019032012170264400_bmy113C24","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/jm00095a019","article-title":"Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines","volume":"35","author":"Van Maarseveen","year":"1992","journal-title":"Journal of Medicinal Chemistry"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C25","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.75.2.928","article-title":"Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives","volume":"75","author":"Umezawa","year":"1978","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C26","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-00574-9","volume-title":"Plant drug analysis: a thin layer chromatography atlas","author":"Wagner","year":"1996"},{"issue":"6","key":"key\n\t\t\t\t2019032012170264400_bmy113C27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1600-0404.1995.tb00479.x","article-title":"Plasma levels of the \u03b2\u2010carbolines harman and norharman in Parkinson\u2019s disease","volume":"92","author":"Kuhn","year":"1995","journal-title":"Acta Neurologica Scandinavica"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuro.2007.12.001","article-title":"Elevated blood harmane (1-methyl-9H-pyrido [3, 4-b] indole) concentrations in essential tremor","volume":"29","author":"Louis","year":"2008","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C29","first-page":"171","article-title":"Analysis of 1-methyl-1,2,3,4-tetrahydro-\u03b2-carboline in human urine and cerebrospinal fluid by gas chromatography-mass spectrometry","volume":"1","author":"Allen","year":"1980","journal-title":"European Journal of Mass Spectrometry"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0024-3205(79)90387-4","article-title":"Harman in human platelets","volume":"25","author":"Bidder","year":"1979","journal-title":"Life Sciences"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/abio.1999.4456","article-title":"Determination of harmane and harmine in human blood using reversed-phased high-performance liquid chromatography and fluorescence detection","volume":"279","author":"Zheng","year":"2000","journal-title":"Analytical Biochemistry"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0014-5793(80)81088-X","article-title":"Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanol","volume":"109","author":"Rommelspacher","year":"1980","journal-title":"FEBS Letters"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-8741(84)90003-5","article-title":"Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and \u03b2-carboline constituents of ayahuasca","volume":"10","author":"McKenna","year":"1984","journal-title":"Journal of Ethnopharmacology"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0378-4347(00)82576-1","article-title":"Determination of pharmacological levels of harmane, harmine and harmaline in mammalian brain tissue, cerebrospinal fuid and plasma by high-performance liquid chromatography with fuorimetric detection","volume":"496","author":"Moncrieff","year":"1989","journal-title":"Journal of Chromatography"},{"issue":"4","key":"key\n\t\t\t\t2019032012170264400_bmy113C35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0091-3057(95)00048-2","article-title":"Metabolic hydroxylation of 1-methyl-1, 2, 3, 4-tetrahydro-\u03b2-carboline in humans","volume":"52","author":"Tsuchiya","year":"1995","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.aca.2006.12.046","article-title":"Determination of \u03b2-carboline alkaloids in foods and beverages by high-performance liquid chromatography with electrochemical detection at a glassy carbon electrode modified with carbon nanotubes","volume":"585","author":"Ag\u00fc\u00ed","year":"2007","journal-title":"Analytica Chimica Acta"},{"issue":"10","key":"key\n\t\t\t\t2019032012170264400_bmy113C37","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/chromsci\/bms191","article-title":"Determination of indole alkaloids and highly volatile compounds in Rauvolfia verticillata by HPLC\u2013UV and GC\u2013MS","volume":"51","author":"Hong","year":"2012","journal-title":"Journal of Chromatographic Science"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C38","first-page":"104","article-title":"Quantitative and qualitative analysis by HPLC of major Peganum harmala alkaloids at different stages of development","volume":"3","author":"Hassani","year":"2013","journal-title":"Journal of Natural Sciences Research"},{"issue":"6","key":"key\n\t\t\t\t2019032012170264400_bmy113C39","first-page":"53","article-title":"Hemolytic effect of total alkaloids from the seeds of Peganum harmala in vitro on erythrocytes of ruminants: sheep, cattle and goats","volume":"3","author":"Mahdeb","year":"2013","journal-title":"Asian Journal of Plant Science and Research"},{"issue":"12","key":"key\n\t\t\t\t2019032012170264400_bmy113C40","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S2222-1808(15)60966-5","article-title":"In vitro study on the inhibitory effect of ketamine to LPS-induced apoptosis in HUVEC culture","volume":"5","author":"Asmoro","year":"2015","journal-title":"Asian Pacific Journal of Tropical Disease"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C41","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/dta.2028","article-title":"Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes","volume":"9","author":"Li","year":"2017","journal-title":"Drug Testing and Analysis"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.aca.2016.12.012","article-title":"Parts-per-trillion detection of harmala alkaloids in Undaria pinnatifida algae by on-line solid phase extraction capillary electrophoresis mass spectrometry","volume":"954","author":"Tascon","year":"2017","journal-title":"Analytica Chimica Acta"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C43","first-page":"104","article-title":"Simultaneous quantification of bergenin, (+)-catechin, gallicin and gallic acid and quantification of \u03b2-sitosterol using HPTLC from Bergeniaciliata (Haw.) Sternb. Forma ligulata Yeo (Pasanbheda)","volume":"1","author":"Rathee","year":"2010","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jpba.2012.03.034","article-title":"HPTLC methods to assay active ingredients in pharmaceutical formulations: a review of the method development and validation steps","volume":"66","author":"Shewiyo","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C45","volume-title":"HPTLC: high performance thin-layer chromatography; quantitative analysis of pharmaceutical formulations","author":"Sethi","year":"1996"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/chromsci\/45.5.251","article-title":"Simultaneous determination of caffeine, ergotamine, and metamizol in solid pharmaceutical formulation by HPTLC-UV-FLD with mass confirmation by online HPTLC-ESI-MS","volume":"45","author":"Aranda","year":"2007","journal-title":"Journal of Chromatographic Science"},{"issue":"19","key":"key\n\t\t\t\t2019032012170264400_bmy113C47","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1016\/j.chroma.2010.12.022","article-title":"TLC for pharmaceutical analysis in resource limited countries","volume":"1218","author":"Kaale","year":"2011","journal-title":"Journal of Chromatography. A"},{"issue":"10","key":"key\n\t\t\t\t2019032012170264400_bmy113C48","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/chromsci\/bmt171","article-title":"Development of a validated stability-indicating HPTLC method for rufinamide in bulk and its pharmaceutical dosage form","volume":"52","author":"Patel","year":"2013","journal-title":"Journal of Chromatographic Science"},{"issue":"02","key":"key\n\t\t\t\t2019032012170264400_bmy113C49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4236\/ajac.2015.62008","article-title":"Development and validation of stability indicating HPTLC assay for determination of gemifloxacin mesylate in dosage forms","volume":"6","author":"Mahmoud","year":"2015","journal-title":"American Journal of Analytical Chemistry"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jchromb.2016.11.013","article-title":"High-performance thin-layer chromatography (HPTLC) for the simultaneous quantification of the cyclic lipopeptides Surfactin, Iturin A and Fengycin in culture samples of Bacillus species","volume":"1044","author":"Geissler","year":"2017","journal-title":"Journal of Chromatography B"},{"issue":"1\u20132","key":"key\n\t\t\t\t2019032012170264400_bmy113C51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0378-4347(97)00272-7","article-title":"Sensitive high-performance liquid chromatographic assay method for the determination of picroside I in plasma","volume":"698","author":"Dwivedi","year":"1997","journal-title":"Journal of Chromatography B"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C52","first-page":"277","article-title":"Estimation of tropane alkaloids using high performance thin layer chromatography","volume":"76","author":"Gupta","year":"1999","journal-title":"Journal of the Indian Chemical Society"},{"issue":"13","key":"key\n\t\t\t\t2019032012170264400_bmy113C53","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1081\/JLC-120039420","article-title":"Qualitative and quantitative HPTLC methods for quality control of Stephania tetrandra","volume":"27","author":"Blatter","year":"2004","journal-title":"Journal of Liquid Chromatography & Related Technologies"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1556\/1006.2017.30.1.8","article-title":"Authentication of honeys of different floral origins via high-performance thin-layer chromatographic fingerprinting","volume":"30","author":"Locher","year":"2017","journal-title":"Journal of Planar Chromatography"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.chroma.2006.04.082","article-title":"High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix puerariae Lobate and Radix puerariae Thomsonii","volume":"1121","author":"Chen","year":"2006","journal-title":"Journal of Chromatography. A"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11816-009-0096-5","article-title":"Embryogenic callus culture of Tribulus terrestris L. a potential source of harmaline, harmine and diosgenin","volume":"3","author":"Nikam","year":"2009","journal-title":"Plant Biotechnology Reports"},{"issue":"5","key":"key\n\t\t\t\t2019032012170264400_bmy113C57","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/jaoac\/91.5.1179","article-title":"High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala","volume":"91","author":"Pulpati","year":"2008","journal-title":"Journal of AOAC International"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C58","author":"International Conference on Harmonization","year":"2005"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0731-7085(02)00568-X","article-title":"HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L","volume":"31","author":"Kartal","year":"2003","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S2229-4708(10)11004-8","article-title":"Bioanalytical method validation: an updated review","volume":"1","author":"Tiwari","year":"2010","journal-title":"Pharmaceutical Methods"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C61","doi-asserted-by":"crossref","first-page":"E156","DOI":"10.1208\/aapsj0902017","article-title":"Key elements of bioanalytical method validation for macromolecules","volume":"9","author":"Kelley","year":"2007","journal-title":"The AAPS Journals"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C62","doi-asserted-by":"crossref","DOI":"10.1201\/9780203910214","volume-title":"Thin-Layer Chromatography, revised and expanded","author":"Fried","year":"1999"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C63","author":"U. S. FDA\u2014Guidance for Industry","year":"2001"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C64","volume-title":"(621) Chromatography","author":"U.S. Pharmacopeia 29 General Chapters","year":"2006"},{"issue":"2","key":"key\n\t\t\t\t2019032012170264400_bmy113C65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.healthpol.2007.12.010","article-title":"The use of Minilabs\u00ae to improve the testing capacity of regulatory authorities in resource limited settings: Tanzanian experience","volume":"87","author":"Risha","year":"2008","journal-title":"Health Policy (Amsterdam, Netherlands)"},{"issue":"4","key":"key\n\t\t\t\t2019032012170264400_bmy113C66","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jpba.2008.04.012","article-title":"Iridoid glycoside-based quantitative chromatographic fingerprint analysis: a rational approach for quality assessment of Indian medicinal plant Gambhari (Gmelina arborea)","volume":"47","author":"Yadav","year":"2008","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12298-009-0007-9","article-title":"Multiple shoot regeneration and alkaloid cerpegin accumulation in callus culture of Ceropegia juncea Roxb","volume":"15","author":"Nikam","year":"2009","journal-title":"Physiology and Molecular Biology of plants"},{"issue":"3","key":"key\n\t\t\t\t2019032012170264400_bmy113C68","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1556\/1006.2017.30.3.7","article-title":"High-performance thin-layer chromatography and indirect TLC-HRMS-based determination of 20-hydroxyecdysone in Sesuvium portulacastrum","volume":"30","author":"Muchate","year":"2017","journal-title":"Journal of Planar Chromatography-Modern TLC"},{"issue":"9","key":"key\n\t\t\t\t2019032012170264400_bmy113C69","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/jps.2600740913","article-title":"A new approach for dealing with the stability of drugs in biological fluids","volume":"74","author":"Timm","year":"1985","journal-title":"Journal of Pharmaceutical Sciences"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C70","first-page":"65","article-title":"Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test","volume":"7","author":"Monsef","year":"2004","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"issue":"1","key":"key\n\t\t\t\t2019032012170264400_bmy113C71","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jrs.4140","article-title":"TLC\u2010SERS study of Syrian rue (Peganum harmala) and its main alkaloid constituents","volume":"44","author":"Pozzi","year":"2013","journal-title":"Journal of Raman Spectroscopy"},{"issue":"11","key":"key\n\t\t\t\t2019032012170264400_bmy113C72","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.jasms.2005.07.012","article-title":"Evaluation of matrix effect and chromatography efficiency: new parameters for validation of method development","volume":"16","author":"Rogatsky","year":"2005","journal-title":"Journal of the American Society for Mass Spectrometry"},{"key":"key\n\t\t\t\t2019032012170264400_bmy113C73","first-page":"789","article-title":"Ayurveda and natural products drug discovery","volume":"86","author":"Patwardhan","year":"2004","journal-title":"Current Science"}],"container-title":["Journal of Chromatographic Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/chromsci\/article-pdf\/57\/4\/312\/28171219\/bmy113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T22:09:23Z","timestamp":1694470163000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/chromsci\/article\/57\/4\/312\/5272758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":73,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,1,4]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/chromsci\/bmy113","relation":{},"ISSN":["0021-9665","1945-239X"],"issn-type":[{"value":"0021-9665","type":"print"},{"value":"1945-239X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,1,4]]}}}